2011
DOI: 10.1515/jpem.2011.291
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Evaluation of two dietary treatments in obese hyperinsulinemic adolescents

Abstract: Hyperinsulinemia increases the risk of cardiovascular disease in obese children. Only a few treatments are available to decrease insulin resistance. The reduction of hyperinsulinemia by dietary means would be a simple, physiologic and economic way to reduce the risk of metabolic disease. Objective: To compare the effects of two low-energy diets on serum insulin concentrations and weight loss in obese hyperinsulinemic adolescents. Materials and methods: Eighty-six randomly assigned insulin-resistant obese adole… Show more

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Cited by 20 publications
(15 citation statements)
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“…Based on the pertinence of the abstract, 1,524 of them were excluded; the remaining 190 were read in extenso . Thirty‐five of them were considered pertinent (1 non‐randomized trial and 34 randomized controlled trial [RCT]) and were thus included in the meta‐analyses, together with the 37 studies (31 RCT and 6 non‐randomized trial) already included in Waters et al . meta‐analysis .…”
Section: Resultsmentioning
confidence: 99%
“…Based on the pertinence of the abstract, 1,524 of them were excluded; the remaining 190 were read in extenso . Thirty‐five of them were considered pertinent (1 non‐randomized trial and 34 randomized controlled trial [RCT]) and were thus included in the meta‐analyses, together with the 37 studies (31 RCT and 6 non‐randomized trial) already included in Waters et al . meta‐analysis .…”
Section: Resultsmentioning
confidence: 99%
“…Reduced IS is well-accepted as a CVD risk factor in other populations (8), but the role of insulin resistance in T1D is less appreciated, in part due to the difficulty of estimating IS in people with T1D (3;810). Our data are significant in that monitoring and controlling IS may be an important therapeutic target to reduce CVD risk in T1D, especially given that both potential lifestyle (diet (11) and exercise (12)) and pharmacologic options (such as metformin (13)) are available to improve IS.…”
Section: Discussionmentioning
confidence: 99%
“…Four studies tested specific dietary strategies, such as meal replacements or low-fructose diet [62][63][64]. The diets reduced BMI; however, diminishing impact and long-term maintenance were concerns.…”
Section: Treatment Interventionsmentioning
confidence: 99%