Evaluation of two‐step haemoglobin screening with HemoCue for blood donor qualification in mobile collection sites

Gómez-Simón, Antonia; Plaza, E.; Ferrer‐Marín, Francisca; Sánchez-Guiu, Isabel; Vicente, Vicente; Lozano, Marı́a Luisa; Rivera, José

doi:10.1111/vox.12165

Cited by 3 publications

(7 citation statements)

References 30 publications

(56 reference statements)

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“…The errors in the capillary sampling of blood show the extent to which preanalytical errors can influence the results in point-of-care devices. The satisfactory results with venous sampling coupled with the unsatisfactory results with the capillary sampled Hb, supporting other studies,[ 5 7 ] show the difficulty in implementing a satisfactory point of care diagnostic or screening device. Even though the analytical quality of the devices seems to be satisfactory, preanalytical errors seem to be the primary determinants in the determination of quality or lack thereof of HemoCue devices.…”

Section: Discussionsupporting

confidence: 76%

“…Similar findings were found in a Spanish study, due to which they recommended a two-step strategy for Hb screening with the HemoCue. [ 5 ] Briefly, a two-step strategy entails re-testing of the venous blood if and when the prospective donor fails to have satisfactory Hb by capillary sampled blood. Since the venous sampled Hb by HemoCue is satisfactory for blood bank screening, this can be an ideal strategy in the present scenario.…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 4 ] Although this method has been found satisfactory by some users, others have found HemoCue to result in a high number of inappropriate donor rejections. [ 5 6 7 ] HemoCue can estimate Hb both from venous as well as capillary blood. It is unclear Hb from which mode of blood collection was validated in some method comparison studies.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the accuracy of capillary hemoglobin estimation and venous hemoglobin estimation by two models of HemoCue against automated cell counter hemoglobin measurement

Jain

Chowdhury

2020

Asian J Transfus Sci

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BACKGROUND: HemoCue point of care devices has been extensively used in screening for anemia in blood banking. HemoCue can estimate hemoglobin (Hb) both from venous as well as capillary blood. However, the suitability of HemoCue Hb estimation in donor selection is unclear. AIMS: The aims of this study were to evaluate variance of difference in Hb measurement in capillary HemoCue estimation as compared to venous HemoCue estimation from automated cell counter and to assess accuracy of two different HemoCue models (201 and 301) against automated cell counter Hb measurements in both capillary as well as venous blood. MATERIALS AND METHODS: HemoCue 201 and 301 were evaluated by a comparison of methods study against Sysmex XP-100 three-part analyzer at a blood bank of a tertiary care hospital in Uttarakhand, India, in 2017. Assessment for anemia of 115 donors was done initially by capillary Hb by a convenience sampling to 2 instruments from 2 different models of HemoCue (total of 4 instruments). Venous blood collected was analyzed by Sysmex XP-100 and all HemoCue analyzers. RESULTS: For capillary method, bias ranged from −0.97 to −0.37 g/dL, upper limit of agreement (LOA) ranged from 0.72 to −1.06 g/dL, and lower LOA ranged from −2.65 to −1.79 g/dL. For venous method, bias ranged from −0.03 to −0.24 g/dL, the upper LOA ranged from 0.81 to −1.07 g/dL, and lower LOA ranged from −1.04 to −0.57 g/dL. Thus, capillary HemoCue estimation exhibited greater bias as well as wider LOA. Variance of the differences from automated counter was significantly lower for venous HemoCue comparison compared to capillary HemoCue estimation ( P < 0.001 for each instrument). CONCLUSION: Errors in capillary sampling of blood show the extent to which preanalytical errors can influence results in point-of-care devices. We suggest augmentation of any blood bank-based Hb screening process based just on capillary sampling to be augmented by a properly selected venous sampling to reduce deferral for a false-positive screen of anemia.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of the accuracy of capillary hemoglobin estimation and venous hemoglobin estimation by two models of HemoCue against automated cell counter hemoglobin measurement

Jain

Chowdhury

2020

Asian J Transfus Sci

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“…22 Greater variation is also found in higher haemoglobin values. 30 As mentioned previously, while the vast majority of anaemic students are likely to be iron deficient, this is not true for all. In addition, some anaemic students were unable to be followed up in our study so the response to treatment was unable to be measured for all.…”

Section: Discussionmentioning

confidence: 93%

Anaemia in school‐aged children in an Australian Indigenous community

Udovicich

Perera

Leahy

2016

Australian J Rural Health

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“…Venous sample measured with a hematology analyzer is widely considered the gold standard in Hb measurement, but most POC analyzers are also suited for venous blood analysis, often with results well in accordance with those given by a hematology analyzer [8][9][10][11][12]. Therefore, venous sampling provides a promising means to assess Hb at the donation site in the blood donors whose skinprick Hb result is feared unreliable.…”

Section: Introductionmentioning

confidence: 99%

Venous sample is superior to repeated skin‐prick testing in blood donor haemoglobin second‐line screening

et al. 2020

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Background Blood donor haemoglobin concentration (Hb) is commonly measured from a skin-prick sample. However, the skin-prick sample is prone to preanalytical error and variation, which may lead to false deferrals due to low Hb. Study Design and Methods We assessed the efficacy of two second-line screening models for the evaluation of blood donors failing the initial skin-prick test. In the venous model (n = 305), Hb was measured from a venous sample at the donation site. In the skin-prick model (n = 331), two additional skin-prick samples were measured. All on-site Hb measurements were performed with HemoCue Hb201+ (HemoCue AB) point-of-care (POC) device. Hb in the venous samples was later also determined with a hematology analyzer (Sysmex XN, Sysmex Co.) to obtain the donor's correct Hb. A questionnaire evaluated Blood Service nurses' preferences regarding Hb assessment. Results Significantly less donors were deferred from donation with venous model (40%) than with skin-prick model (51%; chi-square test P = 0Á004). Only two donors (0Á7%) were incorrectly accepted in the venous model. Further, Blood Service nurses preferred venous model over skin-prick model. After the study, the venous model was implemented nationwide, and in the first two months after implementation, the deferral rate due to low Hb decreased from 2Á7% to 1Á9%. Conclusion A venous sample for blood donor Hb second-line screening significantly decreased low Hb deferrals compared to repeated skin-prick testing without compromising donor safety. Valuable donations can be recovered by implementing a practical second-line screening model based on venous sampling.

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Evaluation of two‐step haemoglobin screening with HemoCue for blood donor qualification in mobile collection sites

Abstract: Double haemoglobin measurement with HemoCue [fingerstick and venous blood if required] is feasible and allows a significant recovery of blood donations.

Cited by 3 publications

References 30 publications

Comparison of the accuracy of capillary hemoglobin estimation and venous hemoglobin estimation by two models of HemoCue against automated cell counter hemoglobin measurement

Comparison of the accuracy of capillary hemoglobin estimation and venous hemoglobin estimation by two models of HemoCue against automated cell counter hemoglobin measurement

Anaemia in school‐aged children in an Australian Indigenous community

Venous sample is superior to repeated skin‐prick testing in blood donor haemoglobin second‐line screening

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