Improving communities and the urban built environment to promote good health, wellness, and wellbeing has become a top priority globally. This growing trend, evident also in the Sustainable Development Goals’ urgent call for action, has a significant influence on the real estate sustainable development process, which is mostly expressed through design, and is understood as a key value creator in the real estate sector, for all dimensions of the build environment. In order to shed further light on this complex matter, with reference to the perceived impact of sustainable real estate design upon wellbeing, cross-sectional data collected through a survey (n = 150, RR = 75%) were used. The results, obtained from descriptive statistics, regression analysis, variables correlation, and partial least squares-structural equation modeling analysis that incorporated the assessment of measurement and structural models, suggest a positive correlation among the design elements and health, wellness, and wellbeing aspects. The findings are considered significant in terms of filling the gap in the currently published scholarly literature, further supporting the importance of interdisciplinary urban sustainability among real estate professionals.