Evaluation of Urine Cytology in Urothelial Carcinoma with respect to the Paris System for Reporting Urinary Cytology

Das, Soumitra

doi:10.18535/jmscr/v5i11.111

Cited by 2 publications

(5 citation statements)

References 5 publications

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“…7 In Das et al's study, the measured sensitivity and positive predictive value were 86.95% and 83.3%, respectively. 20 In the present study, using TPS, sensitivity was around 87.88%, and positive predictive value was 64.44%, which is in line with the results of most studies.…”

Section: Resultssupporting

confidence: 92%

“…For example, in the study of Malviya et al, using TPS, the rate of HGUC increased from 7.3% to 13%, the sensitivity rose from 68% to 95%, and the negative predictive value increased from 46% to 86% . In Das et al's study, the measured sensitivity and positive predictive value were 86.95% and 83.3%, respectively . In the present study, using TPS, sensitivity was around 87.88%, and positive predictive value was 64.44%, which is in line with the results of most studies.…”

Section: Discussionsupporting

confidence: 89%

“…21 Das et al claimed that none of their cases had threedimensional papillary clusters, concerning LGUN diagnosis, which could be due to the application of voided urine samples, which causes the cells to shed more individually compared with papillary clusters. 20 In our study, the HGUC group showed an increased rate of approximately 8%. Some cases with the diagnosis of AUC and SHGUC were reclassified as HGUC in TPS, and the LGUN group was not appreciable as there were only two cases with TPS.…”

Section: Resultssupporting

confidence: 47%

“…In the study of McIntire et al, the number of LGUN diagnoses was doubled when TPS was applied . Das et al claimed that none of their cases had three‐dimensional papillary clusters, concerning LGUN diagnosis, which could be due to the application of voided urine samples, which causes the cells to shed more individually compared with papillary clusters . In our study, the HGUC group showed an increased rate of approximately 8%.…”

Section: Discussionmentioning

confidence: 45%

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Reclassification of urinary cytology regarding The Paris System for Reporting Urinary Cytology with cytohistological correlation demonstrates high sensitivity for high‐grade urothelial carcinoma

Anbardar

Monjazeb

2020

Diagnostic Cytopathology

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Background Recently, The Paris System for Reporting Urinary Cytology (TPS) has led to major changes in the approach to evaluate urine cytology and pattern of reporting. The aim of this study was to reclassify urine cytology reports with TPS in order to determine the frequency of abnormal results compared with the previous system; also, we performed cytohistological correlation in abnormal cytological results. Methods In this study, the voided urine specimens from the patients referred to Shiraz University of Medical Sciences affiliated laboratories were retrieved and analyzed using the laboratory's electronic records system; slides prepared from the samples were reviewed by single cytopathologist blindly according to the proposed criteria of TPS. Results Totally, 1842 urine cytology slides from 828 patients were blindly evaluated by TPS criteria and compared with routine urine cytology classification. Then, available cytohistological correlation was done on 99 abnormal urine cytological results from 58 patients. Among the 26 cytology slides with atypical urothelial cell (AUC) in the previous classification, eight (30.70%) slides were downgraded to negative results, and four (15.30%) were upgraded to higher groups. Therefore, through the reclassification of the slides with TPS, 46% of the AUC changed to other groups. Diagnostic accuracy of the TPS classified urine cytology was 78%, including 87.88% sensitivity, 27.27% specificity, 64.44% positive predictive value, and 60% negative predictive value. Conclusion The findings of the present study confirmed the importance and utility of TPS regarding the reclassification of AUC to other groups and its high sensitivity for detecting high‐grade urothelial carcinoma (HGUC).

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Section: Resultssupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Section: Resultssupporting

confidence: 47%

Section: Discussionmentioning

confidence: 45%

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Reclassification of urinary cytology regarding The Paris System for Reporting Urinary Cytology with cytohistological correlation demonstrates high sensitivity for high‐grade urothelial carcinoma

Anbardar

Monjazeb

2020

Diagnostic Cytopathology

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“…The introduction of the new Paris classification improved both UC sensitivity (SE), which is ranging from 34 to 95%, and negative predictive value (NPV), ranging from 46 to 86%. However, specificity (SP) remains lower than 70% (31,32). Accuracy varies with the experience of pathologists in interpreting the findings of urinary cytology (33).…”

Section: Discussionmentioning

confidence: 99%

Xpert Bladder Cancer Monitor May Avoid Cystoscopies in Patients Under “Active Surveillance” for Recurrent Bladder Cancer (BIAS Project): Longitudinal Cohort Study

et al. 2022

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ObjectivesTo test the hypothesis that patients under active surveillance (AS) for Non-muscle Invasive Bladder Cancer (NMIBC) who were negative on longitudinal re-testing by the Xpert® Bladder Cancer Monitor (Xpert BC Monitor) assay may avoid unnecessary cystoscopies and urine cytology (UC).Subjects/Patients (or Materials) and MethodsThis is a prospective cohort study of patients enrolled in the AS protocol for recurrent NMIBC (Bladder Cancer Italian Active Surveillance, BIAS project), whose urine samples were analyzed by Xpert BC Monitor upon entry in the study (T0). Patients who had a negative Xpert test and did not fail AS, underwent additional Xpert tests after 4 (T1), 8 (T2), and 12 (T3) months. The clinical utility of Xpert was assessed by determining the number of cystoscopies and UC that could be avoided within 1 year.ResultsOverall, 139 patients were tested with Xpert at T0. Median follow-up was 23 (IQR 17–27) months. Sixty-eight (48.9%) patients failed AS, 65 (46.7%) are currently on AS, and 6 (4.3%) were lost at follow-up. At T0 57 (41.0%) patients had a negative test and 36 (63.2%) are still in AS. In patients with 2 consecutives negative Xpert tests, we could have avoided 73.9% of unnecessary cystoscopies, missing 26.4% failure, up to avoid all cystoscopies with 4 negative tests missing only 12% of failure. All the patients with negative Xpert had negative UC. Failure-free-survival at median follow-up (23 month) stratified for having 0, 1, or ≥2 negative tests was 67.0, 55.1. and 84.1, respectively.ConclusionOur findings suggest that Xpert BC Monitor assay, when it is longitudinally repeated, could significantly reduce the number of unnecessary cystoscopies and UC during their follow-up.

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Evaluation of Urine Cytology in Urothelial Carcinoma with respect to the Paris System for Reporting Urinary Cytology

Cited by 2 publications

References 5 publications

Reclassification of urinary cytology regarding The Paris System for Reporting Urinary Cytology with cytohistological correlation demonstrates high sensitivity for high‐grade urothelial carcinoma

Reclassification of urinary cytology regarding The Paris System for Reporting Urinary Cytology with cytohistological correlation demonstrates high sensitivity for high‐grade urothelial carcinoma

Xpert Bladder Cancer Monitor May Avoid Cystoscopies in Patients Under “Active Surveillance” for Recurrent Bladder Cancer (BIAS Project): Longitudinal Cohort Study

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