Evaluation of use of left coronary artery inflow and O<sub>2</sub> content of coronary sinus blood as a measure of left ventricular metabolism

Rayford, Claudia R.; Khouri, Edward M.; Lewis, F; Gregg, Donald E.

doi:10.1152/jappl.1959.14.6.1072-s

Cited by 8 publications

(10 citation statements)

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“…14 This ratio has also been found to be fairly stable in the presence of asystole from vagal or potassium stoppage, hemorrhage, and fibrillation. 15 Therefore, it is believed that the results truly represent the uptake of oxygen by the left ventricle.…”

Section: Discussionmentioning

confidence: 99%

Oxygen Uptake of the Nonworking Left Ventricle

McKeever

Gregg

Canney

1958

Circulation Research

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151

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Comparisons have been made in the open chest dog of the oxygen usage of the left ventricle whose external work has been reduced to zero by 4 different procedures. The average oxygen usage of the left myocardium/100 Gm./min. is about 2.0 cc. in complete arrest with vagal stimulation or with intracoronary potassium injection; 3.8 cc. in fibrillation; and 3.4 cc. in the empty but beating heart. The oxygen value in the arrested heart approximates 27 per cent of that in the control state and the uptake during vagal stoppage varies directly with the control metabolic level. In the fibrillating ventricle the higher values are related to the intensity of fibrillatory movements, and in the empty beating heart to the control metabolic rate and to the frequency of the heart beat. The experiments with vagal arrest also permit estimation of the oxygen debt of the myocardium.

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Section: Discussionmentioning

confidence: 99%

Oxygen Uptake of the Nonworking Left Ventricle

McKeever

Gregg

Canney

1958

Circulation Research

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151

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“…We therefore consider that we also successfully collected coronary blood flow with our cannula in this study. RAYFORD et al (1959) also showed that the collection rate and the rate of right coronary arterial drainage into the coronary sinus were not affected by catecholamines. Therefore, we consider the V02-DP relations in the HR Table 2.…”

Section: V02-dp Relationshipmentioning

confidence: 87%

“…Earlier reports indicate that approximately 60-80% of left coronary artery flow could be collected by the coronary sinus cannulation (GREGG and SHIPLEY, 1947). This collection rate was raised to 80-90% with a better fitted cannula (RAYFORD et al, 1959). They reported that CBF was 96±9 (S.D.)…”

Section: V02-dp Relationshipmentioning

confidence: 97%

Dissociation of pressure-rate product from myocardial oxygen consumption in dog.

et al. 1987

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Although the pressure-rate product (double product; DP) is generally recognized as a good index of myocardial oxygen consumption (V02), catecholamines are reported to change the V02-DP relationship. However, the separate influences of chronotropism and inotropism on the V02-DP relation have not been studied. Therefore, we examined these influences in anesthetized open-chest dogs by cardiac pacing and dobutamine infusion. We observed two different V02-DP lines under the separate chronotropic and inotropic changes. We interpreted such V02-DP relations by the concept of the pressure-volume area (PVA). PVA is a measure of total mechanical energy for ventricular contraction and is a specific area in the ventricular pressure-volume (P-V) diagram circumscribed by the end-systolic and end-diastolic P-V relation curves and the systolic segment of the P-V trajectory. The empirical V02-PVA relation that had been obtained in our previous studies reasonably simulated the dissociation of DP from Vo2 under separate changes in chronotropism and inotropism.Key words ; myocardial energetics, determinant of oxygen consumption, double product, pressure-volume area.Since the pressure-rate product (double product; DP) was proposed as a good index for the oxygen cost of mechanical activity in canine heart (GEROLA et al., 1957;KATZ and FEINBERG, 1958), many investigators have reported reasonably good correlations (approximately r = 0.8) between DP and myocardial oxygen consumption (Vo2) under broad conditions of hemodynamics (BALLER et al., 1981; ROOKE and FEIGL, 1982). Both in the normal and ischemic human hearts, DP also highly correlates with Vo2 under atrial pacing and exercise

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“…In most cases no premedication was necessary; in a few, 1 ml of a mixture of meperidine (25 mg per ml), Phenergan (6.25 mg per ml), and chlorpromazine (6.25 mg per ml) was given intramuscularly. Special care was taken to place the catheter deep in the proximal coronary sinus where homogeneity of sampling has been observed (17), and maximal representation of left ventricular events may be expected (20). Measurements of blood oxygen content were made immediately prior to and at least 3 minutes after onset of supine leg-raising; exercise was sufficient to raise mean myocardial oxygen consumption by 42 per cent (11.2 to 15.9 ml per 100 g per minute) and total body oxygen consumption by 112 per cent (145 to 307 ml per minute per m2).…”

Section: Methodsmentioning

confidence: 99%

Myocardial Lactate and Pyruvate Metabolism*

Krasnow¹,

Neill²,

Messer³

et al. 1962

J. Clin. Invest.

128

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Although the heart has been considered primarily an aerobic organ, recent work (1) has reemphasized the possibility that measurement of oxygen consumption alone may not 1)e adequate to define the total energy utilization under all conditions. The role of anaerobic metabolism must be reviewed.Methods of defining as well as quantifying anaerobiosis are currently in dispute. When oxidation and glycolysis proceed at the same rate, carbohydrate is oxidized to CO2 and H20. Lactate arises whenever the rate of glycolysis exceeds the rate of oxidation. Net production of lactate by an organ, as evidenced for example by venous concentration greater than arterial, has been considered to represent anaerobic metabolism due to cellular hypoxia (2). More recent work (3) has demonstrated that large changes in lactate production can occur unassociated with hypoxia, but related instead to increased pyruvate production. Huckabee introduced the concept of "excess lactate" in order to distinguish between pyruvateinduced changes in lactate and those related solely to a shift in DPN: DPNH redox potential. This was inferred from alterations in arterial lactatepyruvate ratio and the relative arteriovenous differences of the two substrates. "Excess lactate," so defined, was considered an indicator of cellular oxygenation and was used quantitatively as a measure of anaerobic metabolic rate.Anaerobic metabolism in cardiac muscle has been considered to occur only under extreme conditions. Whereas earlier work (4-9) showed lactate production only sporadically with stresses of hypoxia, shock, or myocardial emboli, Huckabee (1) found that in dogs the stress of either 10 per cent oxygen breathing or leg exercise would result in myocardial excess lactate despite positive

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Evaluation of use of left coronary artery inflow and O₂ content of coronary sinus blood as a measure of left ventricular metabolism

Cited by 8 publications

References 0 publications

Oxygen Uptake of the Nonworking Left Ventricle

Oxygen Uptake of the Nonworking Left Ventricle

Dissociation of pressure-rate product from myocardial oxygen consumption in dog.

Myocardial Lactate and Pyruvate Metabolism*

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Evaluation of use of left coronary artery inflow and O2 content of coronary sinus blood as a measure of left ventricular metabolism

Cited by 8 publications

References 0 publications

Oxygen Uptake of the Nonworking Left Ventricle

Oxygen Uptake of the Nonworking Left Ventricle

Dissociation of pressure-rate product from myocardial oxygen consumption in dog.

Myocardial Lactate and Pyruvate Metabolism*

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Product

Resources

About

Evaluation of use of left coronary artery inflow and O₂ content of coronary sinus blood as a measure of left ventricular metabolism