Evaluation of various cardiac autonomic indices in patients with familial Mediterranean fever on colchicine treatment

Canpolat, Uğur; Dural, M.; Aytemir, Kudret; Akdoğan, Ali; Kaya, Ergün Barış; Şahiner, Levent; Yalçın, Ulvi; Canpolat, Asena Gökçay; Çalgünerı, Meral; Kabakçı, Giray; Tokgözoğlu, Lâle; Oto, Ali̇

doi:10.1016/j.autneu.2011.11.001

Cited by 26 publications

(15 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased QTdisp 20 and a positive correlation of QTdisp with C-reactive protein (CRP) has also been described in Turkish FMF patients 21. Increased QTdisp is is reported to directly correlate with susceptibility to complex ventricular rhythm disorders and sudden cardiac death 22-24.…”

Section: Introductionmentioning

confidence: 95%

P Wave Dispersion and QT Dispersion in Adult Turkish Migrants with Familial Mediterranean Fever Living in Germany

Giese¹,

Örnek²,

Kurucay³

et al. 2014

Int. J. Med. Sci.

View full text Add to dashboard Cite

Background: Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease associated with subclinical inflammation, which includes atherosclerosis arising from endothelial inflammation, which in turn increases the risk of atrial or ventricular arrhythmias. Conduction abnormalities can be detected using the electrocardiographic (ECG) indices P and QT dispersion (Pdisp and QTdisp). Currently, it is unknown whether patients with FMF are more likely to have abnormalities of these ECG indices. Moreover, existing studies were conducted in countries with higher FMF prevalence. We therefore perform the first prospective study assessing Pdisp and QTdisp in adult FMF patients in Germany, where prevalence of FMF is low.Method: Asymptomatic FMF patients (n=30) of Turkish ancestry living in Germany and age-matched healthy controls (n=37) were prospectively assessed using 12-lead ECG.Results: Patients and controls were comparable in gender and body mass index, and patients had higher erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and serum amyloid A (SAA) compared to controls (ESR: 23.7±14.3 vs. 16.1±13,3 mm/1sth, p=0.03, CRP: 0.73±0.9 vs. 0.26±0.4 g/dl, p=0.01, SAA: 3.14±4,8 vs. 0.37±0.3 mg/dl, p<0.01). No statistically significant difference between patients and controls respectively, for Pdisp (43.7±11.9 vs. 47.1±11.2ms, p=0.23), QTdisp (65.9±12.3 vs. 67.6±12.7 ms, p=0.58) or corrected QTdisp (cQTdisp: 73.9±15.0 vs. 76.0±13.3 ms, p=0.55) was found. No correlation could be found between Pdisp or QTdisp or cQTdisp and any of the biochemical markers of inflammation.Conclusion: FMF patients living in Germany show a Pdisp and QTdisp comparable to healthy controls, with no increased risk of atrial or ventricular arrhythmias indicated.

show abstract

Section: Introductionmentioning

confidence: 95%

P Wave Dispersion and QT Dispersion in Adult Turkish Migrants with Familial Mediterranean Fever Living in Germany

Giese¹,

Örnek²,

Kurucay³

et al. 2014

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…Fidanci et al 27 demonstrated that one of the time-domain parameters of HRV calculated and analysed by 24-hour ambulatory electrocardiographic monitoring software was significantly decreased in patients with FMF compared to controls. Similarly, Canpolat et al 28 showed abnormal HRV and HRT values in FMF patients. In light of these studies, we hypothesised that impaired endothelial function reduced coronary flow reserve and caused microvascular ischaemia and inflammation-related fibrosis, which, by affecting ventricular repolarisation, may lead to arrhythmias in FMF patients.…”

Section: Discussionmentioning

confidence: 75%

Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever

Karaman¹,

Karayakalı²,

Erken³

et al. 2017

CVJA

View full text Add to dashboard Cite

SummaryBackground:Familial Mediterranean fever (FMF) is a chronic, recurrent auto-inflammatory disease characterised by self-terminating attacks of fever and sterile polyserositis. The main cause of death in auto-inflammatory diseasesis cardiovascular events. Additionally, auto-inflammatory diseases have potential effects on the myocardial repolarisation parameters, including the T-wave peak-to-end (Tp-Te) interval, cTp-Te interval (corrected Tp-Te) and the cTp-Te/ QT ratio. The aim of this study was to analyse the efficacy of myocardial repolarisation alterations in anticipation of cardiovascular risks in patients with FMF.Methods:This study included 66 patients with FMF and 58 healthy control subjects. Tp-Te and cTp-Te intervals and the cTp-Te/QT ratio were measured from the 12-lead electrocardiogram.Results:In electrocardiographic parameters, analysis of QT, QT dispersion, corrected QT (QTc) and QTc dispersion were similar between the groups. The Tp-Te and cTp-Te intervals and Tp-Te/QT and cTp-Te/QT ratios were significantly prolonged in FMF patients. Multivariate linear regression analyses indicated that erythrocyte sedimentation rate was an independent predictor of a prolonged cTp-Te interval.Conclusions:Our study revealed that when compared with control subjects, Tp-Te and cTp-Te intervals and cTp-Te/QT ratio were increased in FMF patients.

show abstract

“…Various autonomic system disturbances have been noted in patients with other autoimmune rheumatic disorders, including ankylosing spondylitis, fibromyalgia and systemic sclerosis (Stojanovic 2009). Canpolat et al (2011) have also shown disturbed HRV parameters in familial Mediterranean fever, another autoinflammatory disorder. Although altered cardiac autonomic balance has been shown in the hypothyroid and subclinically hypothyroid patients with Hashimoto thyroiditis, there is not any study on the evaluation of cardiac autonomic functions in euthyroid children with Hashimoto thyroiditis (Galetta et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Cardiac Autonomic Regulation Is Disturbed in Children with Euthyroid Hashimoto Thyroiditis

Kilic¹,

Gülgün²,

Tascilar³

et al. 2012

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Hashimoto thyroiditis (chronic autoimmune thyroiditis) is the most common form of thyroiditis in childhood. Previous studies have found autonomic dysfunction of varying magnitude in patients with autoimmune diseases, which is considered a cardiovascular risk factor. We aimed to evaluate the heart rate variability (HRV), a measure of cardiac autonomic modulation, in children with euthyroid Hashimoto thyroiditis (eHT). The study included 32 patients with eHT (27 girls and 5 boys; mean age 11 ± 4.1 years, range 8-16; body mass index 0.47 ± 0.69 kg/m 2 ), as judged by normal or minimally elevated serum TSH levels (normal range: 0.34-5.6 mIU/l) and normal levels of free thyroid hormones (FT4 and FT3) and 38 euthyroid age-matched controls. Patients with eHT and control subjects underwent physical examination and 24-hour ambulatory ECG monitoring. Time-domain parameters of HRV were evaluated for cardiac autonomic functions. Children with eHT displayed significantly lower values of time-domain parameters of SDANN (standard deviation of the averages of NN intervals), RMSSD (square root of the mean of the sum of the squares of differences between adjacent NN intervals), NN50 counts (number of pairs of adjacent NN intervals differing by more than 50 ms) and PNN50 (NN50 count divided by the total number of all NN intervals) for each 5-min interval, compared to healthy controls ( p < 0.05 for each), indicating the decreased beat-to-beat variation of heart rate. In conclusion, eHT is associated with disturbed autonomic regulation of heart rate. Hence, the children with eHT are at higher risk for developing cardiovascular diseases.

show abstract

Evaluation of various cardiac autonomic indices in patients with familial Mediterranean fever on colchicine treatment

Cited by 26 publications

References 28 publications

P Wave Dispersion and QT Dispersion in Adult Turkish Migrants with Familial Mediterranean Fever Living in Germany

P Wave Dispersion and QT Dispersion in Adult Turkish Migrants with Familial Mediterranean Fever Living in Germany

Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever

Cardiac Autonomic Regulation Is Disturbed in Children with Euthyroid Hashimoto Thyroiditis

Contact Info

Product

Resources

About