Evaluation of vascular grafts based on polyvinyl alcohol cryogels

Conconi, Maria Teresa; Borgio, Luca; Liddo, Rosa Di; Sartore, Leonardo; Dalzoppo, Daniele; Amistà, Pietro; Lora, S.; Parnigotto, Pier Paolo; Grandi, Claudio

doi:10.3892/mmr.2014.2348

Cited by 14 publications

(9 citation statements)

References 24 publications

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“…However, the decellularization process can also damage the ECM ( Simon et al, 2003 ), thus negatively affecting the integrity, and mechanical properties of the graft. On the other hand, lyophilization is a physical technique that reduces calcification, and provides a stable graft ( Conconi et al, 2014 ; Bai et al, 2019 ). Nevertheless, mechanical properties, such as suture strength, are not sufficient for clinical use ( Reinhardt et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Tissue-Engineered Vascular Grafts

Durán-Rey

Crisóstomo

Sánchez‐Margallo

et al. 2021

Front. Bioeng. Biotechnol.

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Pathologies related to the cardiovascular system are the leading causes of death worldwide. One of the main treatments is conventional surgery with autologous transplants. Although donor grafts are often unavailable, tissue-engineered vascular grafts (TEVGs) show promise for clinical treatments. A systematic review of the recent scientific literature was performed using PubMed (Medline) and Web of Science databases to provide an overview of the state-of-the-art in TEVG development. The use of TEVG in human patients remains quite restricted owing to the presence of vascular stenosis, existence of thrombi, and poor graft patency. A total of 92 original articles involving human patients and animal models were analyzed. A meta-analysis of the influence of the vascular graft diameter on the occurrence of thrombosis and graft patency was performed for the different models analyzed. Although there is no ideal animal model for TEVG research, the murine model is the most extensively used. Hybrid grafting, electrospinning, and cell seeding are currently the most promising technologies. The results showed that there is a tendency for thrombosis and non-patency in small-diameter grafts. TEVGs are under constant development, and research is oriented towards the search for safe devices.

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Section: Discussionmentioning

confidence: 99%

Systematic Review of Tissue-Engineered Vascular Grafts

Durán-Rey

Crisóstomo

Sánchez‐Margallo

et al. 2021

Front. Bioeng. Biotechnol.

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“…18–21 However, there has been an existing interest of using biopolymeric cryogels in biological and medical applications. 22–26…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20][21] However, there has been an existing interest of using biopolymeric cryogels in biological and medical applications. [22][23][24][25][26] There were several studies reported about the use of gelatin as the main component of any blend cryogels because gelatin is cheap, is easy to manipulate, and it is easy to get a proper mechanical strength comparable to Col. But unfortunately, its biological inductive effect is almost insignificant when comparing with Col. On the other hand, using Col alone for the construction can also be troublesome because it is more sensitive to gelation and manipulation which will lead to weak gel structure and a poor mechanical property.…”

Section: Introductionmentioning

confidence: 99%

Collagen–carboxymethyl cellulose–tricalcium phosphate multi-lamellar cryogels for tissue engineering applications: Production and characterization

Odabaş

2016

Journal of Bioactive and Compatible Polymers

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Collagen-carboxymethyl cellulose-tricalcium phosphate cryogels were prepared for diverse biomedical applications. Further chemical and structural characterizations were performed by Fourier transform infrared spectra, thermogravimetric analysis, X-ray crystallography, and scanning electron microscopy. The mechanical properties were tested by unconfined compression test. Moreover, hemocompatibility of the cryogels was also evaluated by basic biochemical blood testing. Chemical and structural analysis results demonstrate the achievement of the crosslinking without any major alteration in collagen and carboxymethyl cellulose with a thermally and structurally stable blend formation. Scanning electron micrographs demonstrate the multilamellar formation with macro-and micro-pore compositions which can correlate with water uptake results of the cryogels. Hemocompatibility evaluations exhibited that the cryogels are nontoxic and blood-compatible. The overall results including mechanical testing of these tricalcium phosphate-consisting collagen/carboxymethyl cellulose cryogels may have potential use as a material for hard tissue regeneration.

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“…Several polymers have been used to obtain TEBVs: poly(dimethylsiloxane), poly‐ ε ‐caprolactone (PCL), poly(methyl methacrylate), poly‐ l ‐lactic acid (PLLA), polyglycolic acid, poly(glycerol sebacate), and polyvinyl alcohol . Several studies have shown that the behavior of vascular cells (fibroblasts, endothelial, and muscle cells) depends on the topography of biomaterial: presence of fibers or pores, pore size of the fibers, spacing between these elements, roughness, orientation of the fibers, and microscale or nanoscale .…”

Section: Introductionmentioning

confidence: 99%

Facile and selective covalent grafting of an RGD-peptide to electrospun scaffolds improves HUVEC adhesion

et al. 2015

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The development of a biomimetic surface able to promote endothelialization is fundamental in the search for blood vessel substitutes that prevent the formation of thrombi or hyperplasia. This study aims at investigating the effect of functionalization of poly-ε-caprolactone or poly(L-lactic acid-co-ɛ-caprolactone) electrospun scaffolds with a photoreactive adhesive peptide. The designed peptide sequence contains four Gly-Arg-Gly-Asp-Ser-Pro motifs per chain and a p-azido-Phe residue at each terminus. Different peptide densities on the scaffold surface were obtained by simply modifying the peptide concentration used in pretreatment of the scaffold before UV irradiation. Scaffolds of poly-ε-caprolactone embedded with adhesive peptides were produced to assess the importance of peptide covalent grafting. Our results show that the scaffolds functionalized with photoreactive peptides enhance adhesion at 24 h with a dose-dependent effect and control the proliferation of human umbilical vein endothelial cells, whereas the inclusion of adhesive peptide in the electrospun matrices by embedding does not give satisfactory results.

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Evaluation of vascular grafts based on polyvinyl alcohol cryogels

Cited by 14 publications

References 24 publications

Systematic Review of Tissue-Engineered Vascular Grafts

Systematic Review of Tissue-Engineered Vascular Grafts

Collagen–carboxymethyl cellulose–tricalcium phosphate multi-lamellar cryogels for tissue engineering applications: Production and characterization

Facile and selective covalent grafting of an RGD-peptide to electrospun scaffolds improves HUVEC adhesion

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