Evaluation of vitamin D status and its correlation with gonadal function in children at mini‐puberty

Kılınç, Suna; Atay, Enver; Ceran, Ömer; Atay, Zeynep

doi:10.1111/cen.13856

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…Inhibin B has been proposed as a direct marker of Sertoli cell function and indirect marker of spermatogenesis (27,28) , and can be correlated with testis volume and testosterone production (29) , this was proved in this study by the significant positive correlation between serum inhibin B and testosterone levels. Reduction of inhibin B has been ascribed to an early arrest of spermatogenesis or a depletion of germ cells and associated with a reduced testicular volume (29) .…”

Section: Discussionsupporting

confidence: 55%

Vitamin D3 Administration Before and After Detorsion Could Salvage the Testicular Endocrine Function in an Experimental Model of Testicular Torsion/Detortion

Abou-Bakr

2020

Ain Shams Medical Journal

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Background: Testicular torsion is one of the emergencies affecting mostly adolescent males, resulting in sub-fertility if not rapidly and efficiently managed. Oxidative stress, inflammatory response as well as immunological reactions were implicated in its pathogenesis. Recently interest in studying the non-skeletal effects of vitamin D is growing, many researches indicates its antioxidant, antiinflammatory and immuno-modulatory effects. Aim of the Work: Investigating the possible conservative effect of vitamin D 3 treatment on testicular endocrinal function in testicular torsion/detorsion rat model, and elucidating its possible underlying mechanism. Materials and Methods: 24 young adult male albino rats, weighing 120-160 g., were randomly allocated into 3 groups, 8 in each group, Sham operated (SHAM), Testicular torsion/detorsion (T/D) and Testicular torsion/detorsion; vitamin D 3 treated (T/D; D 3) groups. All rats were subjected to measurement of absolute and relative testicular weight (ATW and RTW, respectively), assessment of testicular endocrinal function by serum total testosterone and inhibin B levels. In addition to determination of serum antisperm antibody (AsAb). Testicular tissue was examined for oxidative stress markers; malondialdeyde (T. MDA) and glutathione peroxidase (T, GPx), as well as inflammatory marker; myeloperoxidase (T. MPO). Results: Testicular T/D resulted in significant reduction in ATW, RTW, serum testosterone and inhibin B levels with significant elevation in serum AsAb, T. MDA and T. MPO when compared with SHAM group. On treatment with vitamin D 3 , RTW was significantly increased as compared with T/D group but still significantly less than SHAM group. Serum testosterone level was significantly increased when compared with both SHAM and T/D groups. Inhibin B was significantly increased as compared with T/D group but still not normalized as being significantly less than SHAM group. Serum AsAb, T. MDA and T. MPO were significantly decreased when compared with T/D group, being normalized for T. MDA but still significantly higher for serum AsAb and T. MPO when compared with SHAM group, however, T. GPx was significantly increased as compared with both SHAM and T/D groups. Conclusion: Vitamin D 3 could retrieve the testicular endocrinal dysfunction induced by Torsion/Detorsion by its antioxidant, antiinflammatory and immuno-modulatory effects.

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Section: Discussionsupporting

confidence: 55%

Vitamin D3 Administration Before and After Detorsion Could Salvage the Testicular Endocrine Function in an Experimental Model of Testicular Torsion/Detortion

Abou-Bakr

2020

Ain Shams Medical Journal

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“…Consequently, VDD decreases calcium absorption, exacerbating osteoporosis. Accordingly, the effects of VD supplementation observed in this trial may play a preventive role against osteoporosis during early life42 without any adverse effect on E2 levels. Therefore, the combination may be recommended for improving musculoskeletal outcome 43.…”

Section: Discussionmentioning

confidence: 74%

<p>Assessing the effect of omega-3 fatty acid combined with vitamin D3 versus vitamin D3 alone on estradiol levels: a randomized, placebo-controlled trial in females with vitamin D deficiency</p>

Al-Shaer¹,

Abu-Samak²,

Hasoun³

et al. 2019

CPAA

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Purpose: Outcomes investigating the effect of vitamin D3 (VD3) and omega-3 fatty acids (Omega-3FA) on serum estradiol (E2) are scarce and conflicting. No previous study has investigated the effect of VD3 combination with Omega-3FA on E2 levels. This study was designed to investigate the effect of VD3, Omega-3FA and VD3 plus Omega-3FA on serum E2 levels in premenopausal females diagnosed with vitamin D deficiency (VDD). Subjects and methods: This randomized, placebo-controlled clinical trial was designed to evaluate the effects of 50,000 IU VD3 taken weekly, 300 mg Omega-3FA taken daily and their combination by the study participants for 8 weeks. The mid-follicular serum levels of E2 and 25-hydroxy vitamin D (25OHD) were assessed at 8 weeks. The study was conducted during winter on a convenience sample of healthy premenopausal Jordanian females with diagnosed VDD. Fasting serum levels for 25OHD and E2 were assessed at baseline and the end of the trial (after 8 weeks). Data were entered into SPSS and analyzed. Results: Healthy premenopausal Jordanian females (N=86) with diagnosed VDD, mean age 32.8±8.9 years, were recruited into the study. Supplementation of VD3 alone resulted in a significant increase in serum 25OHD (13.4±7.9-28.2±7.1 ng/mL, P<0.001) and a significant decrease in E2 levels (85.7±16.5-60.3±20.6 pg/mL, P=0.001). Omega-3FA intake led to a significant decrease in serum 25OHD levels (21.2±12.8-13.6±9.2 ng/mL, P=0.001) and a significant increase in E2 levels (56.3±19.2-78.4±23.7 pg/mL, P=0.006). Combination therapy (VD3 plus Omega-3FA) resulted in a significant increase in both 25OHD (12.0±4.7-35.1±9.5 ng/mL, P<0.001) and E2 (43.0±23.4-57.3±31.5 pg/mL, P=0.028) levels. Conclusion: Results of this study provide vital insight into the effects of D3, Omega-3FA and a combination of their supplementation on premenopausal Jordanian females with diagnosed VDD. Eight weeks of therapy led to decreased E2 level by VD3 and increased level by Omega-3FA supplementation. With regard to 25OHD, its level was increased by VD3 and decreased by Omega-3FA supplementation. Combination of VD3 plus Omega-3FA increased the levels of both E2 and 25OHD. Trial registration: This trial was registered at clinicaltrials.gov as NCT03333564.

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“…There is a lack of studies addressing the association of vitamin D deficiency with gonadal and sex hormones in children and adolescents in the pubertal stage. In the study of Kılınç et al (2019), which assessed the association between 25(OH)D levels and gonadal hormones in mini-puberty, which consists of transient activation of the hypothalamic-pituitary-gonadal (HPG) axis within the first few months of life in the healthy infants, they observed that the total testosterone levels were higher in girls with 25(OH)D deficiency than in girls with sufficient levels of vitamin D. On this matter, previous studies have suggested a stimulatory role of vitamin D on testosterone production (Blomberg Jensen 2012; Huang et al 2015;Lorenzen et al 2017). During adulthood, this hormone is produced by the testicular Leydig cells in response to LH stimulation.…”

Section: Discussionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D levels and its relationship with sex hormones, puberty and obesity degree in children and adolescents

Pires

González-Gil

Anguita‐Ruiz

et al. 2020

Child and Adolescent Obesity

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Background/objectives: Puberty and obesity have been associated with vitamin D deficiency but there is a lack of studies assessing this triple relationship at once. Thus, the aim of this study was to evaluate, under a cross-sectional design, the relationship between sex hormone levels and serum 25-hydroxyvitamin D (25(OH)D), taking into account pubertal status and obesity degree. Subjects/methods: A total of 460 participants from the GENOBOX study (241 females), aged 6-18 years were included in the analysis. Children were divided in groups according to their pubertal stage (prepubertal (n = 225) and pubertal (n = 235)) and obesity degree (normal weight children (n = 100) and children with overweight/obesity (n = 360)). Serum 25(OH)D, Follicle-Stimulating Hormone (FSH) and Luteinizing hormone (LH), estradiol and testosterone were measured. 25(OH)D levels were categorized and the hormones concentration wasadjusted by sex and converted into tertiles. Mann Whitney and Kruskal-Wallis tests, and quantile regression were performed. Results: Pubertal children showed lower serum concentrations of 25(OH)D than prepubertal children (median: 20 ng/mL vs. 24 ng/mL, respectively; p = 0.006). Moreover, within normal weight children, differences were found for 25(OH)D levels according to tertiles of testosterone (I: 27 ng/mL; II: 30 ng/mL; III: 19 ng/ mL, p = 0.008). Among overweight/obese, differences were found according to

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Evaluation of vitamin D status and its correlation with gonadal function in children at mini‐puberty

Abstract: A modest effect of 25(OH)D was identified on total testosterone and inhibin B in girls at mini-puberty. The 25(OH)D may have an effect on gonadal function during early life. Randomized controlled trials could clarify the importance of vitamin D on gonadal hormones at mini-puberty.

Cited by 8 publications

References 35 publications

Vitamin D3 Administration Before and After Detorsion Could Salvage the Testicular Endocrine Function in an Experimental Model of Testicular Torsion/Detortion

Vitamin D3 Administration Before and After Detorsion Could Salvage the Testicular Endocrine Function in an Experimental Model of Testicular Torsion/Detortion

<p>Assessing the effect of omega-3 fatty acid combined with vitamin D3 versus vitamin D3 alone on estradiol levels: a randomized, placebo-controlled trial in females with vitamin D deficiency</p>

Serum 25-hydroxyvitamin D levels and its relationship with sex hormones, puberty and obesity degree in children and adolescents

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