Evaluation of Volatility of Bendamustine Using Solid Phase Extraction-Type Extraction Device

Abstract

Bendamustine (BD), a volatile anti-cancer drug in Japan, was quantitatively evaluated using solid phase extraction (SPE)-type extraction device designed for the adsorption of gaseous semi-volatile organic compounds. First, the stability of BD was tested in various conditions, including solvent, temperature, and contact with oxygen. Then, the BD standard solution was spiked on filter paper, and the SPE-type extraction device was connected to the filter downstream. The filter and extraction device were then used to collect clean air. The actual volatility of BD was determined in high-performance liquid chromatography. Even after 24 h of air sampling at 7 L/min (10,080 L), the results demonstrated that BD evaporation was not confirmed. Furthermore, BD evaporation was not confirmed in a 7,000 L air sampling volume of heated air at 50°C. The volatility properties of n-alkanes of C 26 H 54 , C 28 H 58 , and C 30 H 62 in these air sampling conditions were compared. The results show that BD is not volatile at room temperature.

Fibrous Polyimide Stationary Phase for the Separation of Aromatic Compounds in Reversed-Phase Liquid Chromatography

“…Introducing a polymer particle with heat and chemical resistance, a novel type of stationary phase can develop for use under conditions that is difficult to adopt for conventional silicagel-based stationary phases [35]. Synthetic polymer materials have been employed as novel extraction media for sample preparation techniques in LC [36] and gas chromatography (GC) [37,38].…”