Evaluation of volumetric breast density as a risk factor for breast carcinoma in pre- and postmenopausal women, its association with hormone receptor status and breast carcinoma subtypes defined by histology and tumor markers

Singh, Neha; Joshi, Pranjali; Gupta, Anurag; Marak, James R.; Singh, Deepak Kumar

doi:10.1186/s43055-022-00759-3

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…This difference could be due to limited sample size, different ethnicity of our study population, and different software used to analyse ABD. However, no significant difference was seen in ABD of PR-positive vs. PR-negative tumours and HER2-positive vs. HER2-negative tumours, which is in agreement with previous research [16,17].…”

Section: A D E F B Csupporting

confidence: 93%

Association of mammographic breast density measurements and hormone receptor status of breast cancer

Priti,

Dixit,

Garg

et al. 2024

Pol J Radiol

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PurposeBreast cancer is the most frequent cancer in women, with significant mortality. Mammography is a routine investigation for breast disease. A known risk factor for breast cancer is increased breast density. Here, we tried to observe if mammographic density also affects the hormone receptor status of breast cancer, which will help in the understanding of the biological mechanisms of breast cancer development.Material and methodsSuspected breast cancer patients at Lok Nayak Hospital, Delhi, underwent mammography in the Department of Radiodiagnosis. The density of breast contralateral to the mass was assessed using Hologic Quantra software version 2.1.1 [Area Breast Density(ABD)]. The hormone receptor status of all the tumours was recorded on histopathology. Of these, 100 confirmed cases were included in the study.ResultsER-positive, PR-positive, and HER2-positive tumours were seen in 41%, 33%, and 34% patients, respectively. Regarding ER receptor status, the mean ABD for positive and negative tumours was 27% and 23%, respectively, p-value = 0.01, showing significant relation between them. Mean ABD for HER2-positive and -negative tumours was 25% and 24%, respectively, p-value = 0.75. Mean ABD for PR-positive and PR-negative tumours was 23% and 25%, respectively, p-value = 0.42 (not significant).ConclusionsWe found that ER-positive tumours were common in dense breasts, which was statistically significant. However, this was not true for PR and HER2 receptor status. Limited studies have been done to study MD using computerised software and its effect on hormone receptor status, with conflicting results. Further, large, multicentric studies can be useful in understanding the mechanism and providing better treatment for breast cancer patients.

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Section: A D E F B Csupporting

confidence: 93%

Association of mammographic breast density measurements and hormone receptor status of breast cancer

Priti,

Dixit,

Garg

et al. 2024

Pol J Radiol

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3D tomosynthesis evaluation of breast parenchymal density and its association with malignant lesions and menopausal status

Pires,

Rohini

2024

Journal of Medical Imaging and Radiation Sciences

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Volumetric breast density evaluation using fully automated Volpara software, its comparison with BIRADS density types and correlation with the risk of malignancy

Singh

Joshi

Singh

et al. 2022

Egypt J Radiol Nucl Med

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Background Mammography is currently the modality of choice for mass screening of breast cancer, although its sensitivity is low in dense breasts. Besides, higher breast density has been identified as independent risk factor so it has been conceptualized that women with dense breasts should be encouraged for supplemental screening. In this study, we aimed to estimate the distribution of volumetric breast density using fully automated Volpara software and to analyze the level of agreement between volumetric density grades and Breast Imaging Reporting and Data System (BI-RADS) density grades. We also aim to estimate the distribution of breast cancer in different VDG and to find a correlation between VDG and risk of malignancy. Results VDG-c was most common followed by VDG-b and BIRADS grade B was commonest followed by grade C. The density distribution was found inversely related to the age. Level of agreement between VDG and BIRADS grades was moderate (κ = 0.5890). Statistically significant correlation was noted between VDG-c and d for risk of malignancy (p < 0.001). Conclusion Difficulties associated with the use of BI-RADS density categories may be avoided if assessed using a fully automated volumetric method. High VDG can be considered as independent risk factor for malignancy. Thus, awareness of a woman’s breast density might be useful in determining the frequency and imaging modality for screening.

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Evaluation of volumetric breast density as a risk factor for breast carcinoma in pre- and postmenopausal women, its association with hormone receptor status and breast carcinoma subtypes defined by histology and tumor markers

Cited by 3 publications

References 32 publications

Association of mammographic breast density measurements and hormone receptor status of breast cancer

Association of mammographic breast density measurements and hormone receptor status of breast cancer

3D tomosynthesis evaluation of breast parenchymal density and its association with malignant lesions and menopausal status

Volumetric breast density evaluation using fully automated Volpara software, its comparison with BIRADS density types and correlation with the risk of malignancy

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