This paper proposes a multi-condition optimization method based on single condition optimization and weight. This method analyzes and discusses various working states of the wide-body dump truck and optimize its structure. Firstly, the modal shape and natural frequency of the carriage under modal conditions are analyzed using the finite element method. Combined with the mechanic’s theory, the carriage's force, deformation, and stress are studied under the turning and partial load conditions. This part provides a basis for subsequent stability analysis and lightweight research. According to the filtering white noise method and differential equation method, the f-class road model and the vehicle system dynamics model are established in MATLAB to study the influence of road vibration on the stability of the dump truck during operation. The carriage vibration data prove that the road vibration causes the low order resonance of the carriage and affects the stability of the dump truck. This part provides a basis for the subsequent stability optimization. Based on the above analysis, a multi-objective genetic algorithm (MOGA) based on the response surface is used to optimize the structural parameters of the carriage under partial load conditions, turning conditions and modal conditions, to realize the optimization of stability, mass, stress and deformation of the carriage. Finally, the entropy weight method is used to fuse the optimization results of the three working conditions. The correctness of the comprehensive optimization results is verified, and the wide-body dump truck carriage optimization is realized, proving the feasibility of the proposed method.