Evaluation of wound healing activity of ethanolic extract of Azadirachta indica leaves on incision and excision wound models in Wister albino rats

Nagesh, Hunsur Nagendra; Basavanna, P L; Kishore, M. S.

doi:10.18203/2319-2003.ijbcp20151354

Cited by 18 publications

(10 citation statements)

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“…The wound areas recorded were measured using a graph paper (El‐Ferjani et al, ). Contraction rate was assessed according to the formula below (Nagesh et al, ):

(normalWound normalarea normalon normalday 0 - normalwound normalarea normalon normalNth normalday) / (normalWound normalarea normalon normalday 0) \times 100

…”

Section: Methodsmentioning

confidence: 99%

“…The wound areas recorded were measured using a graph paper (El-Ferjani et al, 2016). Contraction rate was assessed according to the formula below (Nagesh et al, 2015):…”

Section: Wound Contraction Ratementioning

confidence: 99%

“…These strategies have palpable inconveniences and undesirable side effects (Shenoy et al, ). Traditional medicine has been promoted by the World Health Organization (WHO) as a more affordable and extensive medical care (Nagesh, Basavanna, & Kishore, ). Wounds and skin disorders attract, nearly, one‐third of herbal medicines in use in comparison to 1–3% of modern drugs.…”

Section: Introductionmentioning

confidence: 99%

“…These strategies have palpable inconveniences and undesirable side effects (Shenoy et al, 2009). Traditional medicine has been promoted by the World Health Organization (WHO) as a more affordable and extensive medical care (Nagesh, Basavanna, & Kishore, 2015).…”

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confidence: 99%

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In vivo wound healing potential and HPLC-PDA-ESI-MS profiling ofZizyphus lotusL. (Desf.) leaves methanol extract

et al. 2018

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This study was performed to evaluate the wound healing potential and antioxidant effect of methanol extract of Zizyphus lotus leaves (MZL), and to identify its phenolic profile by HPLC‐PDA‐ESI‐MS. Wound healing activity was assessed in vivo using excision model. Biochemical and histopathological analyses were conducted. In vitro antioxidant potential of MZL was tested using 2,2‐diphenyl‐1‐picrylhydrazyl and β‐carotene bleaching methods. HPLC‐PDA‐ESI‐MS was used for the phenolic profiling. Animals treated with MZL ointment showed a significant reduction in epithelialization time and high contraction rate compared to controls. Proteins, hydroxyproline, and hexosamines contents of ointment‐treated animals were higher than controls. Marked cross‐linking of collagen fibers and lack of inflammatory cells were observed in the granulation tissue of the ointment‐treated animals. Chemical profiling of MZL revealed that quercetin‐3‐O‐rutinoside and catechin are the major constituents. Phenolic compounds of the methanol extract of Zizyphus lotus leaves may be engaged in the acceleration of the healing process activity. Practical application In Mediterranean region, like Algeria, Zizyphus lotus is used in nutrition, health, and cosmetics. Several parts of this plant are employed to treat urinary troubles, diabetes, skin infections, fever, diarrhea, insomnia, bronchitis, and hypoglycemia. There is no scientific paper investigating the phenolic composition of Z. lotus leaves using a mass spectrometry coupled high‐performance liquid chromatography, as well as examining their wound healing potential. Results from this study revealed the presence of many flavonoids exhibiting important antioxidant and wound healing potentials through specific mechanisms. Z. lotus leaves are a source of pharmacologically active compounds with benefits for human nutrition, health‐promoting, and disease preventing.

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“…The wound areas recorded were measured using a graph paper (El‐Ferjani et al, ). Contraction rate was assessed according to the formula below (Nagesh et al, ):

(normalWound normalarea normalon normalday 0 - normalwound normalarea normalon normalNth normalday) / (normalWound normalarea normalon normalday 0) \times 100

…”

Section: Methodsmentioning

confidence: 99%

“…The wound areas recorded were measured using a graph paper (El-Ferjani et al, 2016). Contraction rate was assessed according to the formula below (Nagesh et al, 2015):…”

Section: Wound Contraction Ratementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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In vivo wound healing potential and HPLC-PDA-ESI-MS profiling ofZizyphus lotusL. (Desf.) leaves methanol extract

et al. 2018

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“…It was found that on introducing carbon tetrachloride in rat's liver, the nimbolide present in azadirachta indica possesses heptoprotective effect against it and also the leaf extract of azadirachta indica have protection against paracetamol-induced liver necrosis in rats [211,212] . The wound healing activity of the extracts of azadirachta indica and T. cordifolia using excision and incision wound models in sprague dawley rats, revealed promotion of wound healing activity [213,214] . Aqueous extract of neem cake inhibited spore germination against three sporulating fungi such as C. lunata, H. pennisetti and C. gloeosporioides F. sp.…”

Section: E Essential Oilsmentioning

confidence: 99%

A Review on Medicinal Importance of Crucial Herbal Products

Patel¹

2021

IJRASET

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Most herbal products are the chief source of medicinal compounds that are known to exhibit various therapeutic properties. Many researchers have ensured the efficacy of traditional medicines at large. The evolving nature of the viruses cause major barriers in the fundamental blockage for illness, instead viruses show complexion which refers to genetic change which lead to accumulate during their lifespan. The immense works have been carried out for the probable best medications to deal with it. For decades, synthetic organic compounds have played a tremendous role in today's medications; however the possibilities for their adverse effects are scaring the human life. The perception to use herbal remedies as complementary vogue can reduce toxicities, has a minimum amount of side effects and can be easily available from nature. The identification of natural products as medicinal drugs is of critical importance and is an excellent source of protease inhibitor. In this review, we focused mainly on the herbal products that give a wide range of anti-viral, anti-cancer, antimicrobial and antioxidant properties which can be used in medications instead of synthetic once. Keywords: Natural products, Herbal medications, Anti-cancer properties, Anti-viral properties, Anti-microbial properties, Antioxidant properties.I. INTRODUCTION Ayurveda, Siddha and Unani had been evolved and used from last 2-3 millennia in the Indian subcontinent and traditional Chinese medicine, having unique understanding of physiology, pathogenesis, pharmacology and pharmaceuticals which are diverse from western biomedicines [1] . According to WHO, there is no sufficient data on efficacy and safety of traditional medicine due to which there is a wide range of research being carried out to make TM as commercial use [2,3] . It was found that many natural products which are evaluated gives good anti-viral properties against Coronavirus, Coxsackievirus, Dengue virus, Enterovirus 71, Hepatitis B virus, Hepatitis virus, Herpes simplex virus, Human immunodeficiency virus, Influenza virus, Measles virus and Respiratory syncytial virus [4] . The evidence for the presence of antiretroviral activity, anti-malarial activity and broad spectrum of anticytoadhesion activity in azadirachta indica leaf extract lead to complete medication without adverse side effects [5] . Azadirachta indica seed oil and its active components have been displayed several pharmacological activities including anti-inflammatory, antiarthritic, antipyretic, hypoglycemic, diuretic, spermicidal, antifungal, antibacterial, anti gastric ulcer, antiviral and anti psoriasis activities [6,7] . Anti-viral and multipotent role of curcumin would be useful against new emerging viruses like bacteria and fungi as well as its synergistic effects like an antioxidant potential, anti-inflammatory and anti-tumoral activity had made it a wonder drug [8] . Curcuminoids are the promising natural compound with a large variety of therapeutic properties [9] . Zika (ZIKV) and Chikungunya (CHIKV) virus lost infectivi...

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Topical application of Azadirachta indica improves epidermal wound healing in hyperglycemic rats

et al. 2021

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Evaluation of wound healing activity of ethanolic extract of Azadirachta indica leaves on incision and excision wound models in Wister albino rats

Cited by 18 publications

References 1 publication

In vivo wound healing potential and HPLC-PDA-ESI-MS profiling ofZizyphus lotusL. (Desf.) leaves methanol extract

In vivo wound healing potential and HPLC-PDA-ESI-MS profiling ofZizyphus lotusL. (Desf.) leaves methanol extract

A Review on Medicinal Importance of Crucial Herbal Products

Topical application of Azadirachta indica improves epidermal wound healing in hyperglycemic rats

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