Evaluation of wound healing activity of GelMA/PCLMA fibrous composites in diabetic model rats

Calland, Francileia Nogueira Albino; Brito, Guilherme de Castro; Sousa, Gustavo Fernandes de; Oliveira, Francílio de Carvalho; Marciano, Fernanda Roberta; Lobo, Anderson Oliveira

doi:10.1016/j.matlet.2023.133893

Cited by 1 publication

(2 citation statements)

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“…The second factor would be due to the associated treatments, since both the GelMA [ 68 ], and photobiomodulation seem to contribute to increased cell metabolism and, consequently, to bone repair. GelMA increases bone tissue due to its inherent bioactivity and physical-chemical adaptability [ 69 ], and due to its porous architecture, it promotes migration, proliferation and osteogenic and chondrogenic differentiation [ 13 , 70 ].…”

Section: Resultsmentioning

confidence: 99%

“…In studies reported by Comunian et al and Ekizer et al [43,64], who evaluated photobiomodulation in bone repair, it was verified that this modality enabled the improvement of neoformation and the quality of the formed bone tissue. This is because photobiomodulation promotes The second factor would be due to the associated treatments, since both the GelMA [68], and photobiomodulation seem to contribute to increased cell metabolism and, consequently, to bone repair. GelMA increases bone tissue due to its inherent bioactivity and physicalchemical adaptability [69], and due to its porous architecture, it promotes migration, proliferation and osteogenic and chondrogenic differentiation [13,70].…”

Section: In Vivo Experimentsmentioning

confidence: 99%

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Evaluation of How Methacrylate Gelatin Hydrogel Loaded with Ximenia americana L. Extract (Steam Bark) Effects Bone Repair Activity Using Rats as Models

Leal,

Gusmão,

Uchôa

et al. 2023

JFB

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The use of bioactive materials, such as Ximenia americana L., to stimulate the bone repair process has already been studied; however, the synergistic effects of its association with light emitting diode (LED) have not been reported. The present work aims to evaluate the effect of its stem bark extract incorporated into methacrylate gelatin hydrogel (GelMA) on the bone repair process using pure hydrogel and hydrogel associated with LED therapy. For this purpose, the GelMA hydrogel loaded with Ximenia americana L. extract (steam bark) was produced, characterized and applied in animal experiments. The tests were performed using 50 male Wistar rats (divided into 5 groups) submitted to an induced tibia diaphyseal fracture. The therapy effects were verified for a period of 15 and 30 days of treatment using histological analysis and Raman spectroscopy. After 15 days of induced lesion/treatment, the new bone formation was significantly higher in the GXG (GelMA + X. americana L.) group compared to the control group (p < 0.0001). After 30 days, a statistically significant difference was observed when comparing the GXLEDG (GelMA + X. americana L. + LED) and the control group (p < 0.0001), the GXG and the control group (p < 0.001), and when comparing the GG, GXG (p < 0.005) and GXLEDG (p < 0.001) groups. The results shows that the Ximenia americana L. stem extract incorporated into GelMA hydrogel associated with LED therapy is a potentiator for animal bone repair.

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