Evaluation of Wound-Healing and Antioxidant Effects of Marantodes pumilum (Blume) Kuntze in an Excision Wound Model

Abstract

Marantodes pumilum (MP) is a great source of herbal medicine used traditionally by both men and women for various purposes. MP may have potential wound-healing effects due to its diverse biological properties. An extensive study was conducted in a normal male rat model for determining the effects of MP var. pumila (MPvp) and var. alata (MPva) on the wound healing process. Here, 126 male Sprague-Dawley rats were divided randomly into seven groups as follows: sham-operated (SH), vehicle dressing (VD), flavine dressing (FD), MPvp leaves (PL), MPvp roots (PR), MPva leaves (AL), and MPva roots (AR). The parameters studied were the percentage of wound contraction, histomorphology study by hematoxylin and eosin (H&E), Masson–Goldner trichrome (MGT), and immunohistochemistry (IHC) staining. In addition, the levels of enzymatic antioxidants and malondialdehyde were also measured in the wound tissue homogenates. Wounds treated with extracts (PL, PR, AL, and AR) showed significantly faster healing (p < 0.05) compared to untreated and control groups (SH, VD, and FD). Histological analysis among MP-treated groups revealed better re-epithelialization, higher collagen deposition, enhanced fibronectin content and fibroblast cells, and higher fiber transformation from collagen-III to collagen-I, accompanied with a significant surge in enzymatic antioxidant activities and a decline in lipid peroxidation. MP has antioxidant effects that may enhance wound healing in the rat model.

Bio-Evaluation of the Wound Healing Activity of Artemisia judaica L. as Part of the Plant’s Use in Traditional Medicine; Phytochemical, Antioxidant, Anti-Inflammatory, and Antibiofilm Properties of the Plant’s Essential Oils

“…The antioxidant activity contributing towards wound healing is in accordance with previous studies reporting enhanced wound healing due to potent antioxidant activities [92]. LP significantly increased in the negative control group (p < 0.0001) compared to the intact group, which accords with previously recorded data [93]. No significant differences in LP were observed in treatment groups with either ArJ or SS groups compared to the negative control, while the ArJ and SS treated groups exhibited significant increases (p < 0.0001) compared to the intact group (Table 5).…”

Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels

“…Wound healing is thus a complicated process that can be affected by several factors including infection, stress, contamination, medication, and sex hormones. Recently, many medications have become available on the world market to treat/heal wounds 21 . However, these treatments exhibit limitations based on cost, treatment time, and toxicity (side effects).…”

“…Various wound healing agents, including anti-inflammatories and antioxidant free radical scavengers, have been reported 21 , 22 . Curcumin or curcuma longa is a plant commonly used as a culinary ingredient but which also exhibits potent antioxidant, antiseptic, anti-inflammatory, blood purifying, and wound-healing agent properties 23 .…”

Wound healing activity of Dillenia ochreata leaves ethanol extract in Wistar rats

“…These results indicated that the active compounds in the ethanolic extract of D. ochreata leaves could increase the epithelialization process, thus accelerating the wound healing process. Epithelial formation begins during the transitional phase, after the inflammatory phase, and before the proliferative phase (Ahmad et al, 2021). In this transitional phase, inflammatory mediators are still released on the burned skin, so epithelialization has not occurred correctly (Tiwari, 2012).…”