Evaluation of wound healing property of Caesalpinia mimosoides Lam.

Bhat, Pradeep; Hegde, Shruti V; Upadhya, Vinayak; Hegde, Ganesh; Habbu, Prasanna V; Mulgund, Gangadhar S.

doi:10.1016/j.jep.2016.10.009

Cited by 30 publications

(41 citation statements)

References 42 publications

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“…Authors, such as Bhat et al, (2016) [22], have also identified several active polyphenolic compounds in the ethanolic extracts of Caesalpinia mimosoides plant. LC-MS revealed the presence of four compounds at different retention times.…”

Section: Discussionmentioning

confidence: 99%

Effect of Leaves of Caesalpinia decapetala on Oxidative Stability of Oil-in-Water Emulsions

et al. 2017

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Caesalpinia decapetala (Roth) Alston (Fabaceae) (CD) is used in folk medicine to prevent colds and treat bronchitis. This plant has antitumor and antioxidant activity. The antioxidant effects of an extract from Caesalpinia decapetala (Fabaceae) were assessed by storage of model food oil-in-water emulsions with analysis of primary and secondary oxidation products. The antioxidant capacity of the plant extract was evaluated by the diphenylpicrylhydrazyl (DPPH), Trolox equivalent antioxidant capacity (TEAC), oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays and by electron paramagnetic resonance (EPR) spectroscopy. Lyophilized extracts of CD were added at concentrations of 0.002%, 0.02% and 0.2% into oil-in-water emulsions, which were stored for 30 days at 33 ± 1 °C, and then, oxidative stability was evaluated. The CD extract had high antioxidant activity (700 ± 70 µmol Trolox/g dry plant for the ORAC assay), mainly due to its phenolic components: gallic acid, quercetin, catechin, 4-hydroxybenzoic acid and p-coumaric acid. At a concentration of 0.2%, the extract significantly reduced the oxidative deterioration of oil-in-water emulsions. The results of the present study show the possibility of utilizing CD as a promising source of natural antioxidants for retarding lipid oxidation in the food and cosmetic industries.

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Section: Discussionmentioning

confidence: 99%

Effect of Leaves of Caesalpinia decapetala on Oxidative Stability of Oil-in-Water Emulsions

et al. 2017

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“…Vasoconstriction is the immediate response to physical aggression, which is caused by prostaglandins and thromboxanes; platelets adhere to exposed collagen and the content is released into granules, while tissue factor activates the coagulation cascade and platelets [ 2 ]. All body tissues are capable of healing by regeneration or repair mechanisms [ 3 , 4 ]. The process of wound healing is divided into three phases: (a) Inflammation process, (b) proliferation, and (c) tissue remodeling.…”

Section: Introductionmentioning

confidence: 99%

Histopathological evaluation of latex of Bellaco-Caspi, Himatanthus sucuuba (Spruce) Woodson on wound healing effect in BALB/C mice

et al. 2020

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Background and Aim: Himatanthus sucuuba (Spruce) Woodson (Apocynaceae) is a medicinal plant known as "Bellaco- Caspi" widely distributed in Loreto, Peru. In the Peruvian traditional medicine, the latex of the plant is used for the treatment of wounds, inflammation, ulcers, and other ailments. This study aims to evaluate the wound healing effect of the latex of H. sucuuba in BALB/C albino mice. Materials and Methods: Thirty BALB/C male mice were used for wound healing study. In the experimental procedures, wound skin incision was performed at 2.0 cm in length until subcutaneous on the paravertebral of each animal. Under locally anesthetized with procaine cream, the treatment was conducted. All the mice were divided into three groups, the control group (A), zinc oxide cream (B), and H. sucuuba latex (C). The entire surface of the wound was treated for all the groups, and the treatments were performed daily for 15 days. The experiments were stopped on days 1, 7, and 15, respectively. Results: The histopathological study of tissues revealed significant changes in wound healing effect in H. sucuuba latex compared to the control and B groups. Consequently, the mice treated with latex showed a significant reduction in epithelialization time and collagen formation. Furthermore, the latex showed a dose-dependent significant reduction of inflammation in the first 24 h of treatment. Conclusion: BALB/C mice treated with the latex of H. sucuuba possess a wound healing effect that can scientifically prove the traditional use of the plant as a wound healing agent.

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“…Natural plant extracts can be beneficial for wound healing if their phytochemical has the antioxidant activities and free radical scavengers, as reported by many previous studies [ 5 ]. Caesalpinia mimosoides extract contains phenolic contents and has a remarkable antioxidant activity leading to the enhancement of the wound healing property [ 10 ]. In line with that, this phenomenon was studied by treating GSE on human primary fibroblast cells to analyze its potential on wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…Bhat et al and Pitz et al found the enhancement of wound healing effects of Caesalpinia mimosoides extract and Jaboticaba fruit peel extract, respectively, probably caused by their phenolic contents [ 10 , 16 ]. Likewise, the wound healing property of GSE might be from its phenolic compound.…”

Section: Discussionmentioning

confidence: 99%

Grammatophyllum speciosum Ethanolic Extract Promotes Wound Healing in Human Primary Fibroblast Cells

Harikarnpakdee

Chowjarean

2018

International Journal of Cell Biology

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Grammatophyllum speciosum is a plant in Orchidaceae family which contains a variety of phytochemical compounds that might be beneficial for medicinal use. This study aimed to evaluate the activity of pseudobulb of G. speciosum extract (GSE) in wound healing processes in human primary fibroblast cells along with in vitro antioxidant activity and total phenolic content of GSE. Scratch wound healing assay indicated that GSE was capable of increasing migration rate after 6 and 9 hours of treatment. Besides, the extract was able to scavenge DPPH, ABTS, and superoxide anion radicals indicating the antioxidative property of GSE. This study suggested a novel role of the of pseudobulb extract of G. speciosum as a wound healing enhancer. The results from this study might be beneficial for the development of further novel active compounds for skin wound healing.

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Evaluation of wound healing property of Caesalpinia mimosoides Lam.

Cited by 30 publications

References 42 publications

Effect of Leaves of Caesalpinia decapetala on Oxidative Stability of Oil-in-Water Emulsions

Effect of Leaves of Caesalpinia decapetala on Oxidative Stability of Oil-in-Water Emulsions

Histopathological evaluation of latex of Bellaco-Caspi, Himatanthus sucuuba (Spruce) Woodson on wound healing effect in BALB/C mice

Grammatophyllum speciosum Ethanolic Extract Promotes Wound Healing in Human Primary Fibroblast Cells

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