Currently, the NCAR (U.S. National Center for Atmospheric Research), the institution responsible for the WRF-Hydro (Weather Research and Forecasting - Hydro) model initiative, highlights four major global challenges: floods, pollution, droughts, and biodiversity. Thus, given the current scenario of a global pandemic caused by the Sars-CoV-2 virus (Covid19), the importance of hydrological studies, their correlation with contamination levels, and incidence of COVID-19 cases are also in the spotlight. Among the challenges around water resources management, the lack of good and representative data, especially for small water bodies and developing countries, to perform inferences and to manage these natural resources is critical. This situation applies not only to observational data and but also to input data for hydrological models. In this context, the WRF-Hydro system represents the state of the art for hydrometeorological modeling. Thus, the model emerges as a computational tool that becomes possible to provide auxiliary data for patterns analysis in time series and computational prediction. Also, with the evolution of artificial intelligence (AI), it is possible to consider the integration of this modern approach with the WRF-Hydro model simulations. Therefore, the main of this study is to analyze the feasibility of a web tool that integrates these functionalities. The coupled WRF-Hydro with AI will support the management and generate a water predictability analysis in the MATOPIBA region (Maranhão-Tocantins-Piauí-Bahia), northeastern Brazil, the focus area of this study. Although the WRF-Hydro system demonstrates efficiency in the hydrometeorological simulation for the region, the model has a range of subprocesses which has a high computational cost, especially for long-term studies. Therefore, due to the possibility of integrating these computational tools, it is proposed to develop and analyze the construction of a web tool using the WRF-Hydro system for the short and medium-term with AI tools for the short term (a few hours to a few days), to optimize the computational cost. Thus, the combined application of the WRF-Hydro and AI system can improve the water bodies management and assist the identification of contamination levels by Sars-CoV-2, given the presence of the virus in water bodies and the correlation of the pandemic with hydrological variables.