Evaluation of zinc and cadmium levels in the biological samples of Ewing sarcomas patients and healthy subjects

Chanihoon, Ghulam Qadir; Afridi, Hassan Imran; Kazi, Tasneem Gul; Talpur, Farah Naz; Baig, Jameel Ahmed

doi:10.1016/j.cca.2021.08.002

Cited by 9 publications

(4 citation statements)

References 45 publications

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“…In OS, the rate-limiting enzyme in serine biosynthesis 3-phosphoglycerate dehydrogenase is inversely correlated with patient survival (93). In ES, two methylenetetrahydrofolate dehydrogenase genes (MTHFD2 and ) were upregulated by EWS-FLI1, and high expressions were linked with high-risk disease and poor survival (73).…”

Section: Amino Acidsmentioning

confidence: 99%

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The opportunities and challenges for nutritional intervention in childhood cancers

et al. 2023

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Diet dictates nutrient availability in the tumor microenvironment, thus affecting tumor metabolic activity and growth. Intrinsically, tumors develop unique metabolic features and are sensitive to environmental nutrient concentrations. Tumor-driven nutrient dependencies provide opportunities to control tumor growth by nutritional restriction or supplementation. This review summarized the existing data on nutrition and pediatric cancers after systematically searching articles up to 2023 from four databases (PubMed, Web of Science, Scopus, and Ovid MEDLINE). Epidemiological studies linked malnutrition with advanced disease stages and poor clinical outcomes in pediatric cancer patients. Experimental studies identified several nutrient dependencies (i.e., amino acids, lipids, vitamins, etc.) in major pediatric cancer types. Dietary modifications such as calorie restriction, ketogenic diet, and nutrient restriction/supplementation supported pediatric cancer treatment, but studies remain limited. Future research should expand epidemiological studies through data sharing and multi-institutional collaborations and continue to discover critical and novel nutrient dependencies to find optimal nutritional approaches for pediatric cancer patients.

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Section: Amino Acidsmentioning

confidence: 99%

“…Besides methionine, serine deprivation has also been shown to induce oxidative stress and prohibit tumor growth in adult cancer models (125,126). Given that NB and ES showed active serine metabolism (49,73), it will be interesting to determine whether serine restriction is effective in treating those cancers.…”

Section: Nutrient Restrictionmentioning

confidence: 99%

The opportunities and challenges for nutritional intervention in childhood cancers

et al. 2023

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“…Toxic cations such as cadmium, lead, and mercury can compete with other physiologically relevant divalent cations for entry into cells and in various biochemical reactions in the body. For example, cadmium absorption and accumulation may increase with zinc deficiency as cadmium can replace zinc in biochemical reactions [ 79 , 80 , 81 , 82 , 83 ]. Cadmium is also known to develop toxicity by competing with essential metal cations including calcium [ 42 , 84 ], iron, copper, and manganese for entry pathways [ 85 ].…”

Section: Accumulation Competition and Toxicity Of Divalent Cationsmentioning

confidence: 99%

Direct Effects of Toxic Divalent Cations on Contractile Proteins with Implications for the Heart: Unraveling Mechanisms of Dysfunction

Gerzen,

Votinova,

Potoskueva

et al. 2023

IJMS

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The binding of calcium and magnesium ions to proteins is crucial for regulating heart contraction. However, other divalent cations, including xenobiotics, can accumulate in the myocardium and enter cardiomyocytes, where they can bind to proteins. In this article, we summarized the impact of these cations on myosin ATPase activity and EF-hand proteins, with special attention given to toxic cations. Optimal binding to EF-hand proteins occurs at an ionic radius close to that of Mg2+ and Ca2+. In skeletal Troponin C, Cd2+, Sr2+, Pb2+, Mn2+, Co2+, Ni2+, Ba2+, Mg2+, Zn2+, and trivalent lanthanides can substitute for Ca2+. As myosin ATPase is not a specific MgATPase, Ca2+, Fe2+, Mn2+, Ni2+, and Sr2+ could support myosin ATPase activity. On the other hand, Zn2+ and Cu2 significantly inhibit ATPase activity. The affinity to various divalent cations depends on certain proteins or their isoforms and can alter with amino acid substitution and post-translational modification. Cardiac EF-hand proteins and the myosin ATP-binding pocket are potential molecular targets for toxic cations, which could significantly alter the mechanical characteristics of the heart muscle at the molecular level.

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“…Studies have shown that iron deficiency anemia can increase a child's absorption of lead, leading to higher levels of BPb. This is because iron deficiency can cause changes in the body that make it easier for lead to be absorbed and stored in the body's tissues [8]. High BPb levels in children can lead to developmental delays, behavioral problems, and other health issues [9].…”

Section: Introductionsmentioning

confidence: 99%

Correlations Between Environmental Enteropathy and Anemia in Pediatric Patients Under Five Years: An Investigation of Lead Exposure

Unar,

Chanihoon

2023

Preprint

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Iron deficiency anemia and elevated blood lead levels (BPb) can have substantial health implications for young children. This study aimed to investigate the prevalence of these conditions among children aged 1 to 5 years attending a daycare center within a pediatric unit. A total of 360 children of varying genders underwent anemia screening, with 230 testing positive and 137 testing negative. Among the anemic children, the severity of anemia was classified as mild and severe based on hemoglobin levels, while non-anemic children constituted the reference group. The findings indicated that anemic children exhibited higher mean BPb values compared to non-anemic children. The prevalence of BPb levels exceeding 100 µg/L was 60% among non-anemic children, 54% among severe anemic children, and 49% among severe anemic children with BPb levels below 200 µg/L. Furthermore, a significant negative correlation was observed between BPb levels and hemoglobin and iron levels in anemic children. Additionally, there was a positive correlation between BPb levels and the age of children of both genders. In conclusion, this study highlights the significant association between BPb levels and key blood parameters, suggesting their potential as biomarkers for lead intoxication and iron-deficient anemia. Future research in this field should focus on elucidating the causal relationships and exploring intervention strategies to reduce lead exposure and prevent iron-deficient anemia in pediatric populations.

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Evaluation of zinc and cadmium levels in the biological samples of Ewing sarcomas patients and healthy subjects

Cited by 9 publications

References 45 publications

The opportunities and challenges for nutritional intervention in childhood cancers

The opportunities and challenges for nutritional intervention in childhood cancers

Direct Effects of Toxic Divalent Cations on Contractile Proteins with Implications for the Heart: Unraveling Mechanisms of Dysfunction

Correlations Between Environmental Enteropathy and Anemia in Pediatric Patients Under Five Years: An Investigation of Lead Exposure

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