EVALUATION OF Α-Glucosidase INHIBITORY POTENTIAL OF METHANOLIC LEAF EXTRACT OF OCIMUM CANUM

Smita, Kumari

doi:10.22159/ijpps.2018v10i1.22268

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…In silico studies suggest that rosmarinic acid has antidiabetic activity [34]. Rosmarinic acid compound is thought to have activity as an inhibitor of the αglucosidase enzyme activity in Ocimum canum [35].…”

Section: Quantitative Analysis Of Callusmentioning

confidence: 99%

Phytochemical Analysis of Callus Two Varieties Orthosiphon Aristatus (Blume) Miq on Murashige and Skoog Media: A Strategic Step of Secondary Metabolite Production

Faramayuda

Mariani

Elfahmi³

et al. 2021

Int J App Pharm

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Objective: The research aimed to provide new information regarding the secondary metabolites content of purple and white-purple Orthosiphon aristatus (Blume) Miq. callus, which can then be used as a basis for developing towards cell suspension and ultimately producing secondary metabolites using bioreactors. Methods: Callus induction of two varieties of O. aristatus were performed by inoculating sterile leaf explants grown on Murashige and Skoog basal media supplemented with 2,4-dichlorophenoxyacetis acid 0.4 ppm. The secondary metabolites were analysed and quantified using high-performance liquid chromatography with gradient elution. Results: The results showed the growth of callus two varieties of O. aristatus in growth media MS with 2,4-D 0.4 ppm. Rosmarinic acid content in the acetone extract of the purple variety callus was 1.28% w/w, and the white-purple variety was 2.22% w/w. Conclusion: This study could form the basis for the development of rosmarinic acid production by In vitro culture modification.

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Section: Quantitative Analysis Of Callusmentioning

confidence: 99%

Phytochemical Analysis of Callus Two Varieties Orthosiphon Aristatus (Blume) Miq on Murashige and Skoog Media: A Strategic Step of Secondary Metabolite Production

Faramayuda

Mariani

Elfahmi³

et al. 2021

Int J App Pharm

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“…Plant extracts are cheaper and easily available in the rural areas [15] . The use of plant extracts to control the fish diseases of fishes is an alternative to the chemotherapy [13,14] The earlier results of the screening of the crude plant extracts which showed the inhibitory properties have been encouraging [16,[21][22][23][24][25] .…”

Section: Fig Iii: Wart Disease Of Gangetic Koi Fish At Tamlukmentioning

confidence: 99%

Wart disease of fresh water fishes due to water pollution and control by plant extracts at Tamluk, East Medinipur, West Bengal, India

2024

JCBSC

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“…There are numerous techniques described that were developed based on the QbD concept, but there are no precise criteria for the development of QbD-based analytical methods. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] The current review paper provides a much more concise summary of the fundamentals of AQbD, as well as its many components, regulatory viewpoint on AQbD, and use of AQbD in the creation of analytical methods for a generic product.…”

Section: 0: Introductionmentioning

confidence: 99%

A Comprehensive Review on the Emerging Concept: QBD Approach to Analytical Method Development and Validation With Regulatory Importance

2023

ecb

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The administration of the pharmaceutical sector is carefully regulated by a quality policy. Regulatory organizations like the USFDA propose the scientific pharmaceutical development process known as Quality by Design (QbD). Due to the increase in the number of quality issues with pharmaceutical items, it has recently become more important. QbD can be used to create quick and reliable analytical methods for critical analysis. A scientific and risk-management strategy is used to achieve method and product understanding in the QbD approach to product and method development, which begins with predetermined targets. Regulatory bodies receive additional assurance from QbD-based product development. The analytical techniques that are used to analyze pharmaceutical drug items are equally vital, and any problems with the analytical technique's design could put patients at risk for poor quality care. As of now, none of the regulatory bodies have any explicit requirements for AQbD (Analytical Quality by Design) in analytical development. Despite the fact that there isn't a formal regulatory agency directive on AQbD, a lot of effort has recently been done in this area. The goal of AQbD is to attain measurement quality. Recently, other regulatory agencies, particularly the EMA (European Medicines Agency) and other ICH countries authorities throughout the world, have shown appreciation for the idea. They are widely acknowledged by the industry as AQbD (Analytical Quality by Design) concepts. The major goal of this review is to clarify the many phases involved in creating an analytical method using a QbD approach, as well as the application of QbD to the validation of analytical procedures and the regulatory significance of applying AQbD.

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EVALUATION OF Α-Glucosidase INHIBITORY POTENTIAL OF METHANOLIC LEAF EXTRACT OF OCIMUM CANUM

Cited by 8 publications

References 24 publications

Phytochemical Analysis of Callus Two Varieties Orthosiphon Aristatus (Blume) Miq on Murashige and Skoog Media: A Strategic Step of Secondary Metabolite Production

Phytochemical Analysis of Callus Two Varieties Orthosiphon Aristatus (Blume) Miq on Murashige and Skoog Media: A Strategic Step of Secondary Metabolite Production

Wart disease of fresh water fishes due to water pollution and control by plant extracts at Tamluk, East Medinipur, West Bengal, India

A Comprehensive Review on the Emerging Concept: QBD Approach to Analytical Method Development and Validation With Regulatory Importance

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