2018
DOI: 10.1186/s12957-018-1483-6
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Evaluation on prognostic efficacy of lymph nodes ratio (LNR) and log odds of positive lymph nodes (LODDS) in complicated colon cancer: the first study in emergency surgery

Abstract: BackgroundLymph node involvement is one of the most important prognostic factors in colon cancer. Twelve is considered the minimum number of lymph nodes necessary to retain reliable tumour staging, but several factors can potentially influence the lymph node harvesting. Emergent surgery for complicated colon cancer (perforation, occlusion, bleeding) could represent an obstacle to reach the benchmark of 12 nodes with an accurate lymphadenectomy. So, an efficient classification system of lymphatic involvement is… Show more

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Cited by 30 publications
(26 citation statements)
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“…Unlike traditional lymph node staging, LODDS is a new method of lymph node staging that has been proposed for a long time. It has been well validated in many tumor models and has been shown to play a better role than the latest eighth version of lymph node staging for GBC [30,31]. Compared with simply classifying lymph nodes based on the presence of lymph node metastasis or the number of lymph node metastases, LODDS can better eliminate the impact of the total number of lymph nodes removed by surgery on the detection rate of positive lymph nodes [28,29].…”
Section: Biomed Research Internationalmentioning
confidence: 99%
“…Unlike traditional lymph node staging, LODDS is a new method of lymph node staging that has been proposed for a long time. It has been well validated in many tumor models and has been shown to play a better role than the latest eighth version of lymph node staging for GBC [30,31]. Compared with simply classifying lymph nodes based on the presence of lymph node metastasis or the number of lymph node metastases, LODDS can better eliminate the impact of the total number of lymph nodes removed by surgery on the detection rate of positive lymph nodes [28,29].…”
Section: Biomed Research Internationalmentioning
confidence: 99%
“…In our series, almost one‐fourth (n = 15, 22%) of primary lymphadenectomies did not obtain the minimum number of 12 LN needed for reliable tumor staging. Several factors can affect LN harvesting such as emergent surgery which was present in 33 (43.4%) patients in our series. Complicated colon cancer presents some technical difficulties which limit the quality and extent of lymphadenectomy as reported by previous authors .…”
Section: Discussionmentioning
confidence: 91%
“…Several factors can affect LN harvesting such as emergent surgery which was present in 33 (43.4%) patients in our series. Complicated colon cancer presents some technical difficulties which limit the quality and extent of lymphadenectomy as reported by previous authors . Another reason for inadequate primary lymphadenectomy could be a suboptimal surgical strategy for pelvic lateral nodes of rectal cancer.…”
Section: Discussionmentioning
confidence: 91%
“…In addition to the AJCC 8 th edition staging system, there are two other unique evaluation systems used clinically: LNR and LODDS. LNR is calculated as follows: amount of PLNs/amount of resected LNs (14,15). Meanwhile, LODDS is defined as the log of the ratio between the number of positive nodes and the number of negative nodes (11).…”
Section: Discussionmentioning
confidence: 99%
“…To address the impact of the number of LN dissections on the detection of PLNs, experts have proposed new methods for improving the staging system of LN metastasis. For example, lymph node ratio (LNR) is considered to be a prognostic LN staging criterion for many types of tumor, including colorectal cancer and thyroid cancer (13)(14)(15). Log odds of positive lymph nodes (LODDS) was first shown to be associated with the prognosis of stage III colon cancer in 2008, has subsequently proven to be a good predictor of patient prognosis in a variety of tumors, and therefore, is considered to be an effective LN staging system (15)(16)(17).…”
Section: Introductionmentioning
confidence: 99%