Evaluation the activity of Matricaria aurea L. and Matricaria chamomilla L. in the treatment of some Inflammatory diseases to justify appropriate Dosage Formulation

Abstract

The Asteraceae family is one of the largest and most numerous families of flowering plants in the world, and to which the genus of Matricaria belongs, which is the object of our study: golden chamomile Matricaria aurea (Loefl.) Sch.Bip. (M. aurea (Loefl.)) and Matricaria chamomilla (L.) (M. chamomilla (L.). These types of Matricaria are widely distributed in Russia and the Middle East and therefore can be successfully used in the treatment of inflammatory diseases. The rich composition of biologically active compounds of chamomile has been well studied in numerous chemical studies. The most active components of M. aurea (Loefl.) are flavonoids, apigenin, luteolin, quercetin, patuletin and, also essential oil components such as α-bisabolol, its oxides and azulenes. M. aurea (Loefl.) contains active substances with anti-inflammatory, antimicrobial, deodorant, carminative, sedative, anticatarrhal and antispasmodic properties. According to many clinical studies, the high potential of M. aurea (Loefl.) for the prevention and treatment of inflammatory diseases of various localization has been convincingly shown. Also, raw M. aurea (Loefl.) can be a source of various compounds used for the treatment of chronic periodontitis. In studies, the antibacterial effect of M. aurea (Loefl.) was obtained in the treatment of inflammatory diseases caused by Bacillus subtilis, Streptococcus pyogenes, S. aureus. It has also been proven effective in inflammatory diseases of the urinary system and intestines, antispasmodic effect. As for M. chamomilla (L.), its most active constituents are farnesene, chamazulene, flavonoids (including apigenin, quercetin, patuletin and luteolin) and coumarin. M. chamomilla (L.) topical preparations are highly effective in the complex treatment of many skin diseases, including ultraviolet-induced erythema, contact dermatitis, phlebitis, atopic eczema, radiodermatitis, and for wound healing. Also, preparations derived from M. chamomilla (L.) are used to treat various diseases, including diabetes, nervous disorders, diarrhea, stomatitis, microbial infections, antiseptic, anti-inflammatory, and gastric disorders. In addition, M. chamomilla (L.) has antioxidant, antibacterial, antifungal, antiparasitic, antipyretic, anti-inflammatory, and analgesic activity.