Evaluation the Effect of Sildenafil Citrate (Sc or Viagra) on Senile Albino Rat Testis (Histological and Biochemical Study)

E-Abdalla, Ezz-Eldin; Moustafa, Abdel-Ghany A.; Amr, Ibrahim M.; Gebaly, Zienab M.

doi:10.21608/ejhm.2012.16227

Cited by 5 publications

(1 citation statement)

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“…This causes erection by promoting smooth muscle relaxation, vasodilation, and increased blood flow into the spongy tissue of the penis 2 . SC induces degenerative changes in the seminiferous tubules as well as interstitial histological alterations, which finally might lead to an arrest of the spermatogenesis 3 .…”

Section: Introductionmentioning

confidence: 99%

EFFECTS OF SILDENAFIL ON THE TESTES OF THE NONDIABETIC AND DIABETIC ADULT ALBINO RATS (Light and Electron Microscopic Study)

Jahin

Al-Jizawi

Abd-Elfattah

2022

Al-Azhar International Medical Journal

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Background: Sildenafil citrate is effective in men with erectile dysfunction. Sildenafil induces degenerative changes in seminiferous tubules and interstitial histological alterations. Diabetes mellitus may cause an end-organ damage in many systems as the genitourinary system. The testis is the primary sex organ and is formed mainly of stroma and parenchyma. It is a mixed gland that performs both endocrine and exocrine activities. Aim of the study: This work aimed to reveal the effect of sildenafil citrate in high and toxic doses on the histological structure of the healthy and diabetic rat testes . Materials and Methods: The research was carried out at the animal house at Faculty of Pharmacy, Al-Azhar University between July, and September 2021. Fifty adult rats were used. They were divided into the following groups: Group I: 10 rats received distilled water daily; group IIA: 10 rats received intraperitoneal injection of sildenafil 9mg/kg/d; group IIB: 10 rats received sildenafil 13.5mg/kg/d, group IIIA: received a single dose of an intraperitoneal injection of 150 mg/kg body weight of alloxan to induce diabetes then sildenafil citrate 9 mg/kg/d, group IIIB: received a single dose of an intraperitoneal injection of 150mg/kg of alloxan to induce diabetes then intraperitoneal injection of sildenafil citrate 13.5mg/kg/d. Animals from all groups were examined 2 months after the start of the experiment. Results: Sildenafil had a toxic effect on the testes of adult albino rats that was more severe with the toxic dose. Also, the changes were mild in non-diabetic and moderate to severe in diabetic rats. Conclusion: Sildenafil had toxic effects on the testes in high doses and also in diabetics.

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Section: Introductionmentioning

confidence: 99%

EFFECTS OF SILDENAFIL ON THE TESTES OF THE NONDIABETIC AND DIABETIC ADULT ALBINO RATS (Light and Electron Microscopic Study)

Jahin

Al-Jizawi

Abd-Elfattah

2022

Al-Azhar International Medical Journal

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Endoplasmic reticulum stress and mitochondrial injury are critical molecular drivers of AlCl3-induced testicular and epididymal distortion and dysfunction: protective role of taurine

Khalaf

Elsamanoudy

Abo-Elkhair

et al. 2022

Histochem Cell Biol

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Aluminum, the third most plentiful metal in the Earth’s crust, has potential for human exposure and harm. Oxidative stress plays an essential role in producing male infertility by inducing defects in sperm functions. We aimed to investigate the role of endoplasmic reticulum (ER) stress and mitochondrial injury in the pathogenesis of aluminum chloride (AlCl3)-induced testicular and epididymal damage at the histological, biochemical, and molecular levels, and to assess the potential protective role of taurine. Forty-eight adult male albino rats were separated into four groups (12 in each): negative control, positive control, AlCl3, and AlCl3 plus taurine groups. Testes and epididymis were dissected. Histological and immunohistochemical (Bax and vimentin) studies were carried out. Gene expression of vimentin, PCNA, CHOP, Bcl-2, Bax, and XBP1 were investigated via quantitative real-time polymerase chain reaction (qRT-PCR), besides estimation of malondialdehyde (MDA) and total antioxidant capacity (TAC). Light and electron microscopic examinations of the testes and epididymis revealed pathological changes emphasizing both mitochondrial injury and ER stress in the AlCl3 group. Taurine-treated rats showed a noticeable improvement in the testicular and epididymal ultrastructure. Moreover, they exhibited increased gene expression of vimentin, Bcl-2, and PNCA accompanied by decreased CHOP, Bax, and XBP1 gene expression. In conclusion, male reproductive impairment is a significant hazard associated with AlCl3 exposure. Both ER stress and mitochondrial impairment are critical mechanisms of the deterioration in the testes and epididymis induced by AlCl3, but taurine can amend this.

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Sildenafil aggravates adriamycin-induced testicular toxicity in rats; a preliminary investigation

Adeyanju

Oyenihi

Oguntibeju

et al. 2021

Drug and Chemical Toxicology

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Evaluation the Effect of Sildenafil Citrate (Sc or Viagra) on Senile Albino Rat Testis (Histological and Biochemical Study)

Cited by 5 publications

References 0 publications

EFFECTS OF SILDENAFIL ON THE TESTES OF THE NONDIABETIC AND DIABETIC ADULT ALBINO RATS (Light and Electron Microscopic Study)

EFFECTS OF SILDENAFIL ON THE TESTES OF THE NONDIABETIC AND DIABETIC ADULT ALBINO RATS (Light and Electron Microscopic Study)

Endoplasmic reticulum stress and mitochondrial injury are critical molecular drivers of AlCl3-induced testicular and epididymal distortion and dysfunction: protective role of taurine

Sildenafil aggravates adriamycin-induced testicular toxicity in rats; a preliminary investigation

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