Evaluation the FLAIR Sensitivity and DWI Post-inject in Comparison with Delayed Enhancement T1w for Better Detection of Active MS Lesions

Hoseinipourasl, M; Zandkarimi, Milad.; Abdolmohammadi, Jamil; Sharifi, Karim; Miraki, Saber

doi:10.31661/jbpe.v0i0.967

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…This was determined by describing active plaques as ultra-bright in comparison with pre-contrast FLAIR images and using subtraction images to confirm the presence of enhancement. Our findings were in line with another study [18] which concluded that CE-FLAIR had the highest sensitivity comparing to CE-T1WI, DWI & ADC in detection of active MS plaques due to the CSF signal suppression in FLAIR, thus offering enough TR time recovery in active enhanced plaques. In their study higher number of active MS plaques in supratentorial region was found on CE-FLAIR comparing to CE-T1WI.…”

Section: Discussionsupporting

confidence: 92%

Contrast enhanced FLAIR versus contrast enhanced T1W images in evaluation of intraparenchymal brain lesions

EL-Adalany

Bilal

Rihan

et al. 2022

Egypt J Radiol Nucl Med

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Background Patients with suspected brain lesions are usually evaluated by means of intravenous contrast materials. These lesions may demonstrate enhancement through different mechanisms. At most institutions, CE-T1WI is the preferred sequence. FLAIR is a sort of inversion recovery pulse sequence with a long TR, TE and T1 and hence effectually nulls signals from CSF. The long T1 causes mild T effect and this result in lesion enhancement on post-contrast study. Therefore, lesions demonstrating enhancement on CE-T1WI will also demonstrate enhancement on CE-FLAIR images. The purpose of this work was to assess the role of CE-FLAIR versus CE-T1WI in evaluation of different intraparenchymal brain lesions. Results Comparing CE-T1WI to CE-FLAIR in various brain pathologies, both observers found higher sensitivity and specificity for lesion to background contrast ratio on CE-FLAIR comparing to CE-T1WI. Observer 1 found that lesion to background contrast ratio on CE-FLAIR had sensitivity of 71.4%, specificity of 66.7% and AUC of 0.661 versus 63.3% sensitivity, 58.3% specificity and 0.634 AUC for CE-T1WI. Observer 2 found that lesion to background contrast ratio on CE-FLAIR had sensitivity of 77.6%, specificity of 66.7% and AUC of 0.719 versus 61.2% sensitivity, 50% specificity and 0.628 AUC for CE-T1WI. Conclusion On comparing CE-FLAIR to CE-T1WI, CE-FLAIR display better lesion detection and enhancement also better soft tissue contrast resolution.

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Section: Discussionsupporting

confidence: 92%

Contrast enhanced FLAIR versus contrast enhanced T1W images in evaluation of intraparenchymal brain lesions

EL-Adalany

Bilal

Rihan

et al. 2022

Egypt J Radiol Nucl Med

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“…МРТ є найбільш чутливим методом виявлення навіть безсимптомної дисемінації уражень. Чутливість цього методу діагностики РС протягом першого року після одноразового нападу становить 94 %, специфічність -83 % [15].…”

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Structural and functional comparisons in cognitive impairments in patients with multiple sclerosis

Teslenko,

Tovazhnyanska,

Kauk

et al. 2024

INJ

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Background. Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease characterized by a variety of neurological symptoms. Cognitive impairment is an important clinical aspect of MS and require careful interviewing and neuropsychological testing to detect it. Contrast-enhanced magnetic resonance imaging (MRI) is the primary diagnostic method in MS, which helps confirm the presence and assess the extent of structural damage to the brain and spinal cord. The purpose of the study was to determine the frequency and severity of cognitive impairment in patients with relapsing-remitting multiple sclerosis, taking into account the localization of brain lesions according to MRI. Materials and methods. Seventy-two patients with a diagnosis of relapsing-remitting MS according to the McDonald criteria (2017) were examined. All of them underwent a thorough neurolo-gical, neuropsychological, and instrumental examination. The average duration of the disease was 8.2 ± 0.8 years. The average score on the Expanded Disability Status Scale was 3.38 ± 0.18 points. Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test 3 (PASAT-3), and Montreal Cognitive Assessment (MoСA) were used to assess the neuropsychological status of patients. All participants underwent a 1.5T MRI of the brain with dotavist contrast enhancement. Results. A thorough survey of examined patients with MS revealed the presence of complaints of cognitive decline in 91.67 % of cases (66 patients). The average score on the SDMT was 32.6 ± 1.6 (controls 57.1 ± 0.9), on the PASAT-3 — 30.3 ± 1.8 (controls 56.8 ± 0.5), the evaluation score on the MoСA was 22.4 ± ± 0.5 points compared to the control group (28.4 ± 0.2 points). The conducted correlation analysis revealed statistically significant negative correlations in the corpus callosum (MoCA: r = –0.255; SDMT: r = –0.263; PASAT-3: r = –0.171; p < 0.05) and in the brainstem (MoCA: r = –0.191; SDMT: r = –0.209; PASAT-3: r = –0.214; p < 0.05). The results of the analysis of variance confirmed the correlations described above between the localization of brain lesions and the results of neuropsychological testing and revealed statistically significant differences in the scores on the MoCA and SDMT depending on the localization of lesions (MoCA: F(14, 57) = 5.052, p < 0.001; SDMT: F(14, 57) = 2.609, p < 0.05). Conclusions. Patients with relapsing-remitting multiple sclerosis quite often have cognitive impairment, which is confirmed by the results of neuropsychological testing. Correlation analysis revealed a significant negative relationship between the localization of foci in the corpus callosum and the brainstem and cognitive decline according to the results of tests (MoCA, SDMT, PASAT-3). The results of our study confirm the presence of structural and functional connections between the localization of focal brain lesions and the development of cognitive disorders, which has important diagnostic and prognostic value.

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Evaluation the FLAIR Sensitivity and DWI Post-inject in Comparison with Delayed Enhancement T1w for Better Detection of Active MS Lesions

Cited by 2 publications

References 20 publications

Contrast enhanced FLAIR versus contrast enhanced T1W images in evaluation of intraparenchymal brain lesions

Contrast enhanced FLAIR versus contrast enhanced T1W images in evaluation of intraparenchymal brain lesions

Structural and functional comparisons in cognitive impairments in patients with multiple sclerosis

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