2015
DOI: 10.3844/ajisp.2015.85.91
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Evaluation the Synergistic Effect of High Dose Radiation of Radioiodine on the Immune System Suppressed By Cyclosporine

Abstract: Abstract:Cyclosporine is an immunosuppressant drug and iodine-131 is the diagnostic and therapeutic radioisotope in nuclear medicine. In this study, we aimed to evaluate the synergistic effect of high-dose radiation of radioiodine on the suppression of the immune system of BALB/cmice after receiving cyclosporine. A total of 50 mice BALB/c were randomly divided into two groups (control and test). Then, 50 mg kg −1 body weight cyclosporine was given to both groups. After 24 h, 0.5 mL iodine-131 was given to the … Show more

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