Evaluation Value of Serum miR-4299 and miR-16-5p in Risk Stratification of Sepsis-Induced Acute Kidney Injury

Pan, Weiwei; Zhang, Junfeng; Hu, Luqi; Huang, Zhiping

doi:10.1155/2022/5165892

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Zhao et al ( 73 ) found that inhibition of miR-16-5p could reduce the symptoms of AKI in mice with ischemia-reperfusion-induced AKI. In addition, it has been reported that serum miR-16-5p ( 74 ) and serum miR-142-5p ( 75 ) are downregulated in septic patients with AKI.…”

Section: Discussionmentioning

confidence: 99%

Urinary microRNAs in sepsis function as a novel prognostic marker

Han

Tian

et al. 2023

Exp Ther Med

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Renal dysfunction is a common complication of sepsis. Early diagnosis and prompt treatment of sepsis with renal insufficiency are crucial for improving patient outcomes. Diagnostic markers can help identify patients at risk for sepsis and AKI, allowing for early intervention and potentially preventing the development of severe complications. The aim of the present study was to investigate the expression difference of urinary microRNAs (miRNAs/miRs) in elderly patients with sepsis and secondary renal insufficiency, and to evaluate their diagnostic value in these patients. In the present study, RNA was extracted from urine samples of elderly sepsis-related acute renal damage patients and the expression profiles of several miRNAs were analyzed. In order to evaluate the expression profile of several miRNAs, urine samples from elderly patients with acute renal damage brought on by sepsis were obtained. RNA extraction and sequencing were then performed on the samples. Furthermore, multiple bioinformatics methods were used to analyze miRNA profiles, including differential expression analysis, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of different miRNA target genes, to further explore miRNAs that are suitable for utilization as biomarkers. A total of four miRNAs, including hsa-miR-31-5p, hsa-miR-151a-3p, hsa-miR-142-5p and hsa-miR-16-5p, were identified as potential biological markers and were further confirmed in sepsis using reverse transcription-quantitative PCR. The results of the present study demonstrated that the four urinary miRNAs were differentially expressed and may serve as specific markers for prediction of secondary acute kidney injury in elderly patients with sepsis.

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Section: Discussionmentioning

confidence: 99%

Urinary microRNAs in sepsis function as a novel prognostic marker

Han

Tian

et al. 2023

Exp Ther Med

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“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”

mentioning

confidence: 99%

Retracted: Evaluation Value of Serum miR‐4299 and miR‐16‐5p in Risk Stratification of Sepsis‐Induced Acute Kidney Injury

International

2023

BioMed Research International

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Systematic review of microRNAs in human acute kidney injury

Douvris,

Viñas,

Akbari

et al. 2024

Renal Failure

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Introduction Early diagnosis of acute kidney injury (AKI) is limited with current tools. MicroRNAs (miRNAs) are implicated in AKI pathogenesis in preclinical models, but less is known about their role in humans. We conducted a systematic review to identify dysregulated miRNAs in humans with AKI. Methods We searched Ovid MEDLINE, Embase, Web of Science, and CENTRAL (August 21, 2023) for studies of human subjects with AKI. We excluded reviews and pre-clinical studies without human data. The primary outcome was dysregulated miRNAs in AKI. Two reviewers screened abstracts, reviewed full texts, performed data extraction and quality assessment (Newcastle Ottawa Scale). Results We screened 2,456 reports and included 92 for synthesis without meta-analysis. All studies except one were observational. Studies were grouped by etiology of AKI: cardiac surgery-associated (CS-AKI, n = 13 studies), sepsis ( n = 25), nephrotoxic ( n = 9), kidney transplant ( n = 26), and other causes ( n = 19). In total, 128 miRNAs were identified to be dysregulated across AKI studies (45 miRNAs upregulated, 55 downregulated, 28 both). miR-21 was the most frequently reported ( n = 17 studies) and it was increased in all etiologies except CS-AKI where it was decreased ( n = 3 studies). Study limitations included bias due to targeted approaches, absence of clinical data/controls, and miRNA normalization methods. Overall study quality was fair (median 5/9, range 2-8 points). Conclusion Dysregulated miRNAs, particularly miR-21, have potential as AKI biomarkers. These results should be interpreted cautiously due to methodological limitations. Standardized methods and unbiased approaches are needed to validate candidate miRNA biomarkers. Registration: International Prospective Register of Systematic Reviews (PROSPERO CRD42020201253)

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Evaluation Value of Serum miR-4299 and miR-16-5p in Risk Stratification of Sepsis-Induced Acute Kidney Injury

Cited by 5 publications

References 24 publications

Urinary microRNAs in sepsis function as a novel prognostic marker

Urinary microRNAs in sepsis function as a novel prognostic marker

Retracted: Evaluation Value of Serum miR‐4299 and miR‐16‐5p in Risk Stratification of Sepsis‐Induced Acute Kidney Injury

Systematic review of microRNAs in human acute kidney injury

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