Evaluations of Corneas in Eyes with Isolated Iris Coloboma

Haşhaş, Arzu Seyhan Karatepe; Arifoğlu, Hasan Basri; Yüce, Yudum; Duru, Necati; Ulusoy, Döndü Melek; Zararsız, Gökmen

doi:10.3109/02713683.2016.1151054

Cited by 5 publications

(2 citation statements)

References 14 publications

(16 reference statements)

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“…Regarding ECD, previous reports have shown obviously condensed ECD in the small cornea. 6,12 By contrast, in this study, ECD was not significantly different among the MC-child and CC groups or the MC-adult and SC groups (Figs. 1, 3).…”

Section: Resultscontrasting

confidence: 77%

“…[20][21][22] Increased ECD has been reported in MC, showing 3436.6 6 316.2 versus 2761.8 6 140.9 cells/mm 2 in patients diagnosed with MC and uveal coloboma, and control patients with normal eyes. 6 In isolated iris coloboma eyes, Karatepe Hashas et al 12 also reported increased corneal ECD in patients with coloboma eyes, with a mean ECD of 3160.7 6 430.9 cells/mm 2 . In this study, ECD of child and adult controls was 3155.13 6 372.67 and 2749.33 6 399.63 cells/mm 2 , respectively, which is consistent with what has been reported in the literature.…”

Section: Discussionmentioning

confidence: 95%

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Corneal Biometric Parameters and Refractive Properties in Microcornea With Normal Axial Length

Jiang

Wang²,

Chen³

et al. 2021

Cornea

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Purpose:The purpose of this study was to evaluate the features of and relationships among corneal diameter, central corneal thickness (CCT), endothelial cell density (ECD), and corneal refractive properties in cases of microcornea (MC) with normal axial length.Methods:We included 22 patients (35 eyes) with MC and cataracts and 41 patients (48 eyes) with isolated cataracts as age-matched controls. They were divided into patients with MC younger than 18 years (MC-child), patients with MC 18 years or older (MC-adult), children with congenital cataracts (CCs), and adults with senile cataracts (SCs). Corneal diameter, axial and anterior chamber length, and keratometry were measured; central corneal endothelial cell imaging was performed.Results:The mean horizontal corneal diameter was 7.71 ± 1.51 and 8.78 ± 0.52 mm in MC-child and MC-adult groups, respectively, and 11.89 ± 0.59 and 11.52 ± 2.42 mm in child and adult controls, respectively. The mean CCT was 641.26 ± 63.37 (MC-child) and 617.38 ± 45.40 mm (MC-adult), and 554.92 ± 34.64 (CC) and 551.58 ± 28.47 mm (SC). The mean ECD was 2898.47 ± 443.90 (MC-child) and 2825.81 ± 484.65 cells/mm2 (MC-adult), and 3155.13 ± 372.67 (CC) and 2749.33 ± 399.63 cells/mm2 (SC). The average keratometry was 44.22 ± 3.14 D (MC-child) and 43.86 ± 2.59 D (MC-adult), and 44.19 ± 1.44 D (CC) and 43.94 ± 1.34 D (SC).Conclusions:Patients with MC and normal axial length possess specific parameters, including significantly smaller corneal diameter and thicker CCT than the patients in the control groups. There were no significant differences in ECD and average keratometry. These parameters should be taken into account in the follow-up and treatment.

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Section: Resultscontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 95%

Corneal Biometric Parameters and Refractive Properties in Microcornea With Normal Axial Length

Jiang

Wang²,

Chen³

et al. 2021

Cornea

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Ocular and Systemic Findings in Adults with Uveal Coloboma

et al. 2020

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Corneal Endothelial Cell Density in Uveal Coloboma Associated With Microcornea

Dhakal

Mohamed

Chaurasia

et al. 2018

Cornea

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Purpose: To evaluate the relationship between endothelial cell density (ECD) and mean corneal diameter (MCD) in eyes with uveal coloboma associated with microcornea. Methods: Corneal endothelial cell imaging was performed using specular microscopy on 22 eyes of 18 subjects diagnosed with uveal coloboma associated with microcornea. The MCD was noted as the average of horizontal and vertical corneal diameters, which were measured using the ruler tool of the slit-lamp biomicroscope and Castroviejo calipers. Results: Mean age of the study subjects was 29.7 ± 10.4 years (range, 14–46 years). The MCD was 7.3 ± 1.1 mm (range, 4.9–9 mm). Mean ECD (3436 ± 316.2 cells/mm2) of the study subjects was significantly (P < 0.0001) higher than the mean ECD (2761.8 ± 140.9 cells/mm2) of age-matched (range, 10–40 years) normal eyes with no ocular pathology. The pleomorphism and polymegathism were comparable between the 2 groups. Regression analysis showed that MCD had a significant negative (R = −0.55; P = 0.02) relationship with ECD. Conclusions: Eyes with congenital uveal coloboma associated with microcornea have increased ECD. Increased ECD may be partly due to a reduced posterior corneal surface area in microcornea.

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Evaluations of Corneas in Eyes with Isolated Iris Coloboma

Abstract: We have determined that a number of factors such as keratometry values, particularly of the corneal endothelium, are different from those of normal eyes. These differences should be taken into account in the follow-up and treatment of eyes with iris coloboma.

Cited by 5 publications

References 14 publications

Corneal Biometric Parameters and Refractive Properties in Microcornea With Normal Axial Length

Corneal Biometric Parameters and Refractive Properties in Microcornea With Normal Axial Length

Ocular and Systemic Findings in Adults with Uveal Coloboma

Corneal Endothelial Cell Density in Uveal Coloboma Associated With Microcornea

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