Evaluative Procedures for Film-Forming Materials Used in Pharmaceutical Applications

Kanig, Joseph L.; Goodman, Harris

doi:10.1002/jps.2600510115

Cited by 91 publications

(40 citation statements)

References 4 publications

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“…The amount of water transmitted through the film was revealed by the weight loss of the assembled cell. The water vapour permeability (WVP, g d -1 mm -2 ) was calculated using the equation (Kanig, Goodman, 1962):…”

Section: Water Vapour Permeabilitymentioning

confidence: 99%

Pharmaceutical films made from the waste material from the preparation of propolis extracts: development and characterization

Toledo

Bavato

Rosseto

et al. 2015

Braz. J. Pharm. Sci.

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This study investigated the development and characterized the physicochemical properties of films obtained from by-products (BP) from the preparation of propolis extracts. Films were produced in the presence and absence of a polymeric adjuvant (gelatin or ethylcellulose) and propylene glycol by a solvent casting method. Density, surface topography by scanning electron microscopy, mechanical properties (folding endurance, tensile strength and percentage elongation), water vapour permeability (WVP), moisture uptake capacity, thermogravimetry, differential scanning calorimetry and Fourier transform infrared spectroscopy (FTIR) were determined. The films were a transparent, light greenishyellow colour, with a uniform surface, and were flexible and easy to handle. The thickness and density of the preparations indicated that the compounds were homogeneously dispersed throughout the film. Mechanical properties were influenced by the film composition; films containing gelatin were more resistant to stress, while those containing ethylcellulose were more flexible. Increasing the adjuvant concentration decreased the elasticity and the rupture resistance, but increased the moisture uptake capacity and WVP of the formulations. BP was thermally stable as were the films. FTIR tests suggested interactions between BP and the adjuvants. This work could contribute to the utilization of BP to prepare films for food and pharmaceutical uses Uniterms: Propolis/byproducts. Propolis/use of waste material/films development. Films/propolis byproducts/physicochemical properties. Polymers. Ethylcellulose. Gelatin.Este estudo investigou o desenvolvimento e as características físico-químicas de filmes obtidos com o resíduo (BP), normalmente descartado, advindo da preparação de extratos de própolis. Os filmes foram produzidos com e sem adjuvantes poliméricos (gelatina ou etilcelulose) e propilenoglicol, pelo método de evaporação de solvente. Foram determinadas a densidade, a topografia de superfície usando microscopia eletrônica de varredura, as propriedades mecânicas (resistência à dobra, tensão e elongação), transmissão de vapor de água (WVP), capacidade de absorção de umidade, termogravimetria, calorimetria exploratória diferencial e espectroscopia de infravermelho com transformada de Fourier (FTIR). Os filmes demonstraram coloração verde-amarelada, transparência, uniformidade de superfície, homogeneidade, flexibilidade e fácil manuseio. A espessura e a densidade das preparações indicaram que os compostos estavam dispersos de forma homogênea. As propriedades mecânicas foram influenciadas pela composição dos filmes e aqueles que continham gelatina apresentaram-se mais resistentes enquanto os compostos por etilcelulose demonstraram maior flexibilidade. Com o aumento da concentração polimérica, a resistência e a elasticidade diminuíam, porém aumentou a capacidade de absorção de água e a WVP das formulações. BP apresentou estabilidade térmica assim como os filmes. Os testes de FTIR sugeriram interações entre o BP e os adjuvantes utilizados. Es...

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Section: Water Vapour Permeabilitymentioning

confidence: 99%

Pharmaceutical films made from the waste material from the preparation of propolis extracts: development and characterization

Toledo

Bavato

Rosseto

et al. 2015

Braz. J. Pharm. Sci.

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“…EC, which, as mentioned, is water insoluble, is produced by reacting alkali-treated cellulose with ethyl chloride (87). Free-standing EC films have been prepared by casting and drying EC solutions in organic solvents such as methanol, ethanol, and toluene (89,114). Hot melts comprised of EC and a vegetable oil (115), mineral oil and an ester plasticizer (116), or an acetylated monoglyceride and a metal salt of a fatty acid (117) have been applied on meat products, particularly frozen meats, to form transparent, tightlyadhering, readily strippable, protective coatings.…”

Section: Cellulose Ethersmentioning

confidence: 99%

“…Their relative hydrophilicities increase in the order of HPC < MC < HPMC < CMC (88). Ethylcellulose (EC) is another film-forming cellulose ether which, in contrast to the aforementioned ethers, is water insoluble (89). Production of cellulose ethers involves treatment of cellulose with alkali and subsequent reaction with etherifying agents (87)(88).…”

Section: Cellulose Ethersmentioning

confidence: 99%

Application of Edible Coatings on Meats, Poultry and Seafoods: A Review

Gennadios

Hanna

Kurth

1997

LWT - Food Science and Technology

415

204

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“…The tensile strength, percentage elongation and modulus of elasticity of selected ratio was compared with standard taste masking polymer, Eudragit ® E-PO in [17][18] . The charged cells were weighed and placed in the desiccators containing anhydrous calcium chloride (0% RH).…”

Section: Film Characterizationmentioning

confidence: 99%

Untitled

2012

IJPSR

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Natural resources in general and plant materials in particular are receiving more attention due to their safety as pharmaceutical excipients. Present work assessed the combination potential of natural hydrophobic resin, rosin, and synthetic polymer ethyl cellulose to mask the abhorrent inherent taste of ambroxol hydrochloride, by microencapsulation technique, and its possibility to formulate as a fast dissolving dosage form. Being of natural origin, rosin and its derivatives are biodegradable and biocompatible. Although It has excellent film forming property the native rosin films are brittle and break easily upon handling. The film forming properties of rosin was modified by substituting a part with ethyl cellulose.The prepared rosinethyl cellulose composite microspheres by emulsion solvent evaporation technique possessed good sphericity, smooth surface morphology, uniform and narrow size distribution (1090 µm), when analyzed by scanning electron microscopy. PEG 400 was used as plasticizer because of its hydrophilicity, biocompatibility and their excellent plasticizing activity. Method of preparation has influenced the particle size and drug loading efficiency. Drug-polymer compatibility was confirmed by Fourier transform infrared spectroscopy and thin layer chromatography. DSC studies revealed that the drug was molecularly dispersed inside the microspheres in the form of solid solution. Sensory studies in healthy human volunteers indicated that the taste and palatability were significantly improved by microencapsulation. This study demonstrated that rosin could be a right choice in developing patient favored formulations for bitter drugs and can be utilized in fast disintegrating dosage forms as well.

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Evaluative Procedures for Film-Forming Materials Used in Pharmaceutical Applications

Cited by 91 publications

References 4 publications

Pharmaceutical films made from the waste material from the preparation of propolis extracts: development and characterization

Pharmaceutical films made from the waste material from the preparation of propolis extracts: development and characterization

Application of Edible Coatings on Meats, Poultry and Seafoods: A Review

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