Evans Blue and other dyes as protein tyrosine phosphatase inhibitors

Shrestha, Suja; Shim, Yi Sup; Kim, Chul; Lee, Keun‐Hyeung; Cho, Hyeongjin

doi:10.1016/j.bmcl.2004.01.079

Cited by 12 publications

(8 citation statements)

References 31 publications

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“…Nevertheless, CSB and analogs have been previously found to inhibit different proteins [21,36,[42][43][44]. Thus, improvements of their inhibitor potency on Rad51 are necessary so that they might be specific enough to the recombinase protein for pharmacological studies on them.…”

Section: Discussionmentioning

confidence: 97%

“…Moreover, the removal of these dyes from effluents becomes a major environmental problem of the textile industry. Considering their potent inhibitory effect on the activity of crucial proteins such as Rad51 highlighted hereby but also other proteins [21,36,42,43], care must be taken in the use of these dyes for clinical or biochemical purposes.…”

Section: Discussionmentioning

confidence: 99%

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Identification and characterization of human Rad51 inhibitors by screening of an existing drug library

Normand

Rivière

Renodon-Cornière

2014

Biochemical Pharmacology

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Identification and characterization of human Rad51 inhibitors by screening of an existing drug library

Normand

Rivière

Renodon-Cornière

2014

Biochemical Pharmacology

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“…The chemical structure of TrB (C 34 H 24 N 6 Na 4 O 14 S 4 ) is shown in Fig. 1(a) [27]. The other chemicals used in this work as NaOH, HCl were from Merck and used without further purification.…”

Section: Methodsmentioning

confidence: 99%

Adsorption kinetics of diazo-dye from aqueous solutions by using natural origin low-cost biosorbents

Şişmanoğlu

Aroguz

2015

Desalination and Water Treatment

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In the present study, the adsorption of diazo-dye onto natural origin low-cost biosorbents prepared from pyrolyzed petrified sediment (PPS), pyrolyzed sawdust from maple bark and chitin was investigated in aqueous solution. Trypan blue (TrB) was used as diazo-dye during the adsorption process. Effects of the operational parameters as contact time and type of adsorbents for the removal of TrB were studied using a batch process. The intraparticle diffusion model, the pseudo-first-order and the pseudo-second-order models were used to examine the kinetic data. Dynamic data of the dye adsorption were also fitted to the intraparticle diffusion model well. The order of the uptaken capacities of dye on these adsorbents was found as chitin > petrified sediment > maple sawdust. Langmuir, Freundlich, Temkin models were employed for fitting the equilibrium adsorption data of TrB. Langmuir and Temkin isotherms were found to represent the data best for the adsorption of TrB onto these adsorbents. The adsorption capacities of the adsorbents PPS, pyrolyzed maple bark sawdust and chitin were obtained to be 345, 72.5, 122 mg g −1 at 298 K, respectively.

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“…As a result, a thermally aggregated protein (such as immunoglobulin G) may persist in solution, surrounded by free dye (Fig. 1.10) [40]. This has been proven through chromatographic separation (on a thin layer of Sephadex G200) of thermally aggregated immunoglobulin G solubilized in complex with the dye.…”

mentioning

confidence: 99%

Supramolecular Systems as Protein Ligands

Rybarska

Piekarska

Stopa

et al. 2017

Self-Assembled Molecules – New Kind of Protein Ligands

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The standard substrate complexation mechanism engages natural binding sites. In contrast, supramolecular structures may form complexes with proteins by penetrating in regions which are either naturally unstable or become temporarily accessible due to structural rearrangements related to the protein's function. This may result in enhancement of irreversible processes (e.g. immune complexation or complement activation) or inhibition of reversible processes (e.g. enzymatic catalysis). Only ribbon-like supramolecular structures may form complexes with proteins. Having anchored itself inside the protein, the supramolecular ligand is protected against environmental factors such as changes in pH. This type of interaction represents a unique, nonstandard phenomenon in the context of proteomics.

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Evans Blue and other dyes as protein tyrosine phosphatase inhibitors

Cited by 12 publications

References 31 publications

Identification and characterization of human Rad51 inhibitors by screening of an existing drug library

Identification and characterization of human Rad51 inhibitors by screening of an existing drug library

Adsorption kinetics of diazo-dye from aqueous solutions by using natural origin low-cost biosorbents

Supramolecular Systems as Protein Ligands

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