Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome

Abstract

Despite current treatments for polycystic ovary syndrome (PCOS), a considerable number of women with this syndrome do not reach the treatment goal, suggesting the presence of other probable misdiagnosed features of this syndrome that are not taken into account in the assessment and therefore in the therapeutical approach. The aim of this study was to investigate the prevalence of chronotype categories in women with PCOS and their role in determining hormonal and metabolic aspects of PCOS. This observational case‐control study was conducted on 112 women with PCOS and 112 healthy women matched for age and body mass index (BMI). At baseline anthropometric parameters such as weight, height, BMI and waist circumference, clinical parameters such as Ferriman−Gallwey (FG) score, biochemical parameters such as fasting plasma glucose, insulin levels and assessment of the homeostasis model of insulin resistance (HoMA‐IR), inflammatory parameters such as C‐reactive protein (CRP) and hormonal parameters such as testosterone levels were evaluated. Women with PCOS had a lower chronotype score (p < .001) which indicates a higher prevalence of evening chronotype (EC) category (p = .037) compared to controls. After adjustment for BMI, chronotype score was significantly negatively correlated with CRP levels (r = −0.418, p < .001), testosterone levels (r = −0.543, p < .001) and FG score (r = −0.514, p < .001). Linear regression analysis showed that high testosterone levels were among the factors most associated with a lower chronotype score (p < .001), followed by BMI (p < .001) and HoMA‐IR (p < .05). In conclusion, there is a higher prevalence of EC in women with PCOS than in women without the condition, which in turn was associated with a worse hormonal and metabolic profile. These findings provide support for the relevance of including chronotype assessment in the treatment of women with PCOS.

A novel model based on necroptosis to assess progression for polycystic ovary syndrome and identification of potential therapeutic drugs

“…Hence, the diagnosis of PCOS is principally based on the classical Rotterdam criteria and clinical symptoms ( 9 ). There is still a lack of precise diagnostic criteria, and many patients often suffer from misdiagnoses or missed diagnoses ( 10 ). Given this, it is essential to discover new biomarkers to facilitate timely diagnosis and intervention for PCOS.…”

How Fast Do “Owls” and “Larks” Eat?

“…Subjects with an evening chronotype are more frequently smokers, sedentary, consume more processed foods and have a lower adherence to the Mediterranean diet [ 27 ]. These and other evening chronotype-related factors could contribute to the risk of developing obesity-related cardiometabolic diseases [ 9 , 28 , 29 ]. Our study adds a new element to this disadvantageous picture of the evening chronotype, that is, a fast eating speed.…”

Can the ketogenic diet improve our dreams? Effect of very low-calorie ketogenic diet (VLCKD) on sleep quality

“…Comprehensive medical information was collected from all participants, and their physical activity levels at baseline were evaluated. Women who performed at least 30 min of aerobic physical activity per day were considered physically active (data were tabulated in dichotomous form “yes” or “no”), as previouslt reported [ 15 , 16 ]. Individuals eligible for this study satisfied the following criteria: women aged 18–69 years, body mass index (BMI) 25.0–50.9 kg/m 2 .…”