This paper studies the input-to-state stability (ISS) for a class of discrete-time time-varying impulsive switched delayed systems, in which the asynchronous phenomena are considered. Asynchronous phenomena here include two implications: asynchronous impulses and switches and asynchronous switching. The former means that the events, that is, impulses and switches, are not necessary to occur simultaneously, while the latter indicates that the actual switching modes and related controllers or specified modes do not coincide. Applying the mode-dependent concept to impulses and switches, both the improved Krasovskii-type and Razumikhin-type ISS criteria are provided. The time differences of Lyapunov functionals or functions here are sign-changing and time-varying, releasing from the traditional assumption that always requires negative definiteness. Meanwhile, in this paper, ISS or non-ISS subsystems and stabilizing or destabilizing impulses are taken into account. Finally, three numerical examples are given to illustrate the effectiveness of the proposed results.