One of the main control objectives in parabolic trough solar thermal plants is to maintain the outlet temperature around an operating point. For this, a synthetic oil flow is used as the main control variable. However, another crucial system of the plant is the defocusing safety system of the collectors to prevent the oil temperature from exceeding an upper limit to prevent its degradation. This will occur, in general, when the oil flow reaches the maximum possible and is not able to regulate anymore the temperature. This mechanism is generally applied based on heuristic rules and partial or total defocus, which leads to a large number of actuator actions and temperature oscillations. In commercial plants, this defocus mechanism is applied firstly to the last collector, and as necessary, other collectors are defocused. In addition, it must be taken into account that loops' parameters will be, in general, different.In this work, a FeedForward-based strategy is proposed to control the outlet temperature of collectors 1, 2 and 3 of a solar plant using the defocus angle as the manipulated variable. It is also proposed to dynamically obtain the setpoint temperatures for the first 3 collectors through an optimization based on the concentrated parameter model. The results of the simulations are presented in different situations where the good performance of the strategy is observed. It is shown how the dynamic modification of the set-points can avoid possible energy losses on occasions where a fixed set-point of temperature is not the optimal option.