Event-by-event fluctuations of observables are often modeled using the Monte Carlo Glauber model, in which the energy is initially deposited in sources associated with wounded nucleons.In this paper, we analyze in detail the correlations between these sources in proton-nucleus and nucleus-nucleus collisions. There are correlations arising from nucleon-nucleon correlations within each nucleus, and correlations due to the collision mechanism, which we dub twin correlations. We investigate this new phenomenon in detail. At the RHIC and LHC energies, correlations are found to have modest effects on size and eccentricity fluctuations, such that the Glauber model produces to a good approximation a collection of independent sources.