Event-Related Brain Potential Correlates of Human Auditory Sensory Memory-Trace Formation

Haenschel, Corinna; Вернон, Д.; Dwivedi, Prabuddh; Gruzelier, John; Baldeweg, Torsten

doi:10.1523/jneurosci.1227-05.2005

Cited by 254 publications

(317 citation statements)

References 51 publications

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“…A Schmidt et al Consistent with other reports using a 'roving' oddball design (Baldeweg et al, 2004;Haenschel et al, 2005), an MMN memory trace effect was found in this study over the frontal cortex; however, no comparable effect was detected over temporal cortical regions. The absence of a temporal MMN memory trace effect suggests that the adaptation hypothesis (Jääskeläinen et al, 2004), which posits that the MMN results from local neuronal adaptation in the auditory cortex, cannot easily explain the MMN memory trace effect found in this study.…”

Section: S-ketamine-induced Cognitive Impairmentssupporting

confidence: 93%

“…Electroencephalographic (EEG) activity was measured during an auditory 'roving' oddball paradigm (Baldeweg et al, 2004;Boly et al, 2011;Garrido et al, 2008;Haenschel et al, 2005), originally developed by Cowan et al (1993). Acoustic stimuli were generated by the E-prime software (Schneider et al, 2002), and applied binaurally through headphones (TDH-39-P; Maico, Minneapolis, MN).…”

Section: Auditory Test Paradigm (Mmn)mentioning

confidence: 99%

“…Instead of a classical oddball paradigm, we use a 'roving' MMN paradigm and examine the formation and strengthening of memory traces (by quantifying the amplitude of the MMN as a function of the number of preceding standards) (Haenschel et al, 2005;Imada et al, 1993). A notable advantage of the roving paradigm is that physical stimulus differences between standards and deviants are varied independently of the number of standard repetitions in the roving paradigm.…”

Section: Introductionmentioning

confidence: 99%

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Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Schmidt

Bachmann

Kometer

et al. 2011

Neuropsychopharmacol

101

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Psychotomimetics like the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine and the 5-hydroxytryptamine2A receptor (5-HT 2A R) agonist psilocybin induce psychotic symptoms in healthy volunteers that resemble those of schizophrenia. Recent theories of psychosis posit that aberrant encoding of prediction errors (PE) may underlie the expression of psychotic symptoms. This study used a roving mismatch negativity (MMN) paradigm to investigate whether the encoding of PE is affected by pharmacological manipulation of NMDAR or 5-HT 2A R, and whether the encoding of PE under placebo can be used to predict drug-induced symptoms. Using a doubleblind within-subject placebo-controlled design, S-ketamine and psilocybin, respectively, were administrated to two groups of healthy subjects. Psychological alterations were assessed using a revised version of the Altered States of Consciousness (ASC-R) questionnaire. As an index of PE, we computed changes in MMN amplitudes as a function of the number of preceding standards (MMN memory trace effect) during a roving paradigm. S-ketamine, but not psilocybin, disrupted PE processing as expressed by a frontally disrupted MMN memory trace effect. Although both drugs produced positive-like symptoms, the extent of PE processing under placebo only correlated significantly with the severity of cognitive impairments induced by S-ketamine. Our results suggest that the NMDAR, but not the 5-HT 2A R system, is implicated in PE processing during the MMN paradigm, and that aberrant PE signaling may contribute to the formation of cognitive impairments. The assessment of the MMN memory trace in schizophrenia may allow detecting early phases of the illness and might also serve to assess the efficacy of novel pharmacological treatments, in particular of cognitive impairments.

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Section: S-ketamine-induced Cognitive Impairmentssupporting

confidence: 93%

Section: Auditory Test Paradigm (Mmn)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Schmidt

Bachmann

Kometer

et al. 2011

Neuropsychopharmacol

101

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“…Altogether, this indicates that the component is to some extent modulated by target predictability, specifically by increments of surprise/prediction error. This effect needs further examination in 'attended' as well as 'unattended' settings with variations of stimulus onset asynchrony, rules, and the physical deviant/target features (Baldeweg, 2006;Haenschel, et al, 2005;Sussman, et al, 1998;Ulanovsky, et al, 2004). …”

Section: Area Of Applicationmentioning

confidence: 99%

Unmixing concurrent EEG-fMRI with parallel independent component analysis

Eichele

Calhoun

Moosmann

et al. 2008

International Journal of Psychophysiology

104

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Concurrent event-related EEG-fMRI recordings pick up volume-conducted and hemodynamically convoluted signals from latent neural sources that are spatially and temporally mixed across the brain, i.e. the observed data in both modalities represent multiple, simultaneously active, regionally overlapping neuronal mass responses. This mixing process decreases the sensitivity of voxel-byvoxel prediction of hemodynamic activation by the EEG when multiple sources contribute to either the predictor and/or the response variables. In order to address this problem, we used independent component analysis (ICA) to recover maps from the fMRI and timecourses from the EEG, and matched these components across the modalities by correlating their trial-to-trial modulation. The analysis was implemented as a group-level ICA that extracts a single set of components from the data and directly allows for population inferences about consistently expressed function-relevant spatiotemporal responses. We illustrate the utility of this method by extracting a previously undetected but relevant EEG-fMRI component from a concurrent auditory target detection experiment. §Corresponding Author:

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“…Repetition effects are thought to reflect ongoing statistical learning during which the generative model is updated. In MMN studies RS often manifests as decrease of the negative component elicited by rare events, i.e., as a relative positivity to repeated stimuli, which was suggested to represent rapid SSA underlying sensory memory formation (Haenschel, Vernon, Dwivedi, Gruzelier, & Baldeweg, 2005). Predictive coding suggests that RS is brought about by fast changes in synaptic connections (Baldeweg, 2006(Baldeweg, , 2007Garrido et al, 2009) within and between hierarchical levels of neural populations.…”

mentioning

confidence: 99%

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

Kremláček

Kreegipuu

Tales

et al. 2016

Cortex

119

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The visual mismatch negativity (vMMN) response is an event-related potential (ERP) component, which is automatically elicited by events that violate predictions based on prior events. VMMN experiments use visual stimulus repetition to induce predictions, and vMMN is obtained by subtracting the response to rare unpredicted stimuli from those to frequent stimuli. One increasingly popular interpretation of the mismatch response postulates that vMMN, similar to its auditory counterpart (aMMN), represents a prediction error response generated by cortical mechanisms forming probabilistic representations of sensory signals. Here we discuss the physiological and theoretical basis of vMMN and review thirty-three studies from the emerging field of its clinical applications, presenting a meta-analysis of findings in schizophrenia, mood disorders, substance abuse, neurodegenerative disorders, developmental disorders, deafness, panic disorder and hypertension. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensory modality and thus of vital importance in environmental information processing and response, and a modality which arguably may be more sensitive to some pathological changes. However, due to the relative infancy of research in vMMN compared to aMMN in clinical populations its potential for clinical application is not yet fully appreciated. The aim of this review and meta-analysis therefore is to present, in a detailed systematic manner, the findings from clinically-based vMMN studies, to discuss their potential impact and application, to raise awareness of this measure and to improve our understanding of disease upon fundamental aspects of visual information processing. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensor...

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Event-Related Brain Potential Correlates of Human Auditory Sensory Memory-Trace Formation

Cited by 254 publications

References 51 publications

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Unmixing concurrent EEG-fMRI with parallel independent component analysis

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

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