Event-related brain potential indices of cognitive function and brain resource reallocation during working memory in patients with Multiple Sclerosis

Covey, Thomas J.; Shucard, Janet L.; Shucard, David W.

doi:10.1016/j.clinph.2016.12.030

Cited by 36 publications

(32 citation statements)

References 90 publications

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“…With regard to our ERP findings, we found group differences with MS patients showing less N2 differentiation between CR and hit trials than HC. Our findings are consistent with the existing literature demonstrating associations between aberrant ERP brain activity and cognitive impairments in MS [55][56][57] . The finding of group differences in N2 adaptation to increasing taskload is strikingly similar to our prior MoBI work comparing younger and older adults 28 .…”

Section: Discussionsupporting

confidence: 93%

“…However, further tests of the N2/d-prime association in MS are required to support the aforementioned conclusion. Of note, recent ERP investigations in MS assessing cognition while participants were stationary (i.e., cognitive-only task) reported evidence in support of compensatory neural functions [55][56][57] . For example, Lopez-Gongora found larger ERP amplitudes in MS relative to HC, even though groups did not differ in their response inhibition performance.…”

Section: Msmentioning

confidence: 99%

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Mobile Brain/Body Imaging of cognitive-motor impairment in multiple sclerosis: deriving EEG-based neuro-markers during a dual-task walking study

Sanctis

Malcolm

Mabie

et al. 2019

Preprint

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Individuals with a diagnosis of multiple sclerosis (MS) often present with deficits in the cognitive as well as the motor domain. The ability to perform tasks that rely on both domains may therefore be particularly impaired. Yet, behavioral studies designed to measure costs associated with performing two tasks at the same time such as dual-task walking have yielded mixed results. Patients may mobilize additional brain resources to sustain good levels of performance. To test this hypothesis, we acquired event-related potentials (ERP) in thirteen individuals with MS and fifteen healthy control (HC) participants performing a Go/NoGo response inhibition task while sitting (i.e., single task) or walking on a treadmill (i.e., dual-task).In previous work, we showed that the nogo-N2 elicited by the cognitive task was reduced when healthy adults are also asked to walk, and that nogo-N2 reduction was accompanied by sustained dual-task performance. We predicted that some MS patients, similar to their healthy peers, may mobilize N2-indexed brain resources and thereby reduce costs. Somewhat to our surprise, the HC group performed the Go/NoGo task more accurately while walking, thus showing a dual-task benefit, whereas, in line with expectation, the MS group showed a trend towards dual-task costs.The expected nogo-N2 reduction during dual-task walking was found in the HC group, but was not present at the group level in the MS group, suggesting that this group did not modulate the nogo-N2 process in response to higher task load. Regression analysis for the pooled sample revealed a robust link between nogo-N2 reduction and better dual-task performance. We conclude that impaired nogo-N2 adaptation reflects a neurophysiological marker of cognitivemotor dysfunction in MS.

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Section: Discussionsupporting

confidence: 93%

Section: Msmentioning

confidence: 99%

Mobile Brain/Body Imaging of cognitive-motor impairment in multiple sclerosis: deriving EEG-based neuro-markers during a dual-task walking study

Sanctis

Malcolm

Mabie

et al. 2019

Preprint

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“…A consistently found event‐related potential during the n ‐back task is a P300 over central–parietal electrodes (for a review see Kok, ). In some studies the amplitude of this P300 decreased with increasing WM load (Covey, Shucard, & Shucard, ; Dong, Reder, Yao, Liu, & Chen, ). In context of the interpretation of this P300 response it is important to note that it is also present in the 0‐back condition, supporting the idea that it is primarily a process of stimulus evaluation (Donchin, Ritter, & McCallum, ).…”

Section: Introductionmentioning

confidence: 92%

Spatiotemporal and spectral dynamics of multi‐item working memory as revealed by the n‐back task using MEG

Costers

Schependom

Laton

et al. 2020

Human Brain Mapping

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Multi-item working memory (WM) is a complex cognitive function thought to arise from specific frequency band oscillations and their interactions. While some theories and consistent findings have been established, there is still a lot of unclarity about the sources, temporal dynamics, and roles of event-related fields (ERFs) and theta, alpha, and beta oscillations during WM activity. In this study, we performed an extensive whole-brain ERF and time-frequency analysis on n-back magnetoencephalography data from 38 healthy controls. We identified the previously unknown sources of the n-back M300, the right inferior temporal and parahippocampal gyrus and left inferior temporal gyrus, and frontal theta power increase, the orbitofrontal cortex.We shed new light on the role of the precuneus during n-back activity, based on an early ERF and theta power increase, and suggest it to be a crucial link between lower-level and higher-level information processing. In addition, we provide strong evidence for the central role of the hippocampus in multi-item WM behavior through the dynamics of theta and alpha oscillatory changes. Almost simultaneous alpha power decreases observed in the hippocampus and occipital fusiform gyri, regions known to be involved in letter processing, suggest that these regions together enable letter recognition, encoding and storage in WM. In summary, this study offers an extensive investigation into the spatial, temporal, and spectral characteristics of n-back multi-item WM activity. K E Y W O R D Shippocampus, magnetoencephalography, n-back, precuneus, working memory

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“…Cognitive event-related potentials (ERPs), mainly the P300 component, are significantly correlated with neuropsychological performance, 133,134 as well as with MRI lesion load. 135 In the latter study, discriminant analysis based on combined MRI and ERPs could classify 79.63% of patients in RR, PP, and SP subgroups.…”

Section: Electrophysiological Outcomesmentioning

confidence: 99%

Fluid biomarker and electrophysiological outcome measures for progressive MS trials

et al. 2017

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Progressive multiple sclerosis (MS) is characterized by insidious clinical worsening that is difficult to accurately quantify and predict. Biofluid markers and electrophysiological measures are potential candidate outcome measures in clinical trials, allowing the quantification of nervous damage occurring in the disease. Neurofilaments are highly specific neuronal proteins. They may have come closest to such applications by their higher concentrations repeatedly demonstrated in cerebrospinal fluid (CSF) in all stages of MS, during relapses, their responsiveness to disease-modifying treatments in relapsing and progressive MS and their associations with measures of inflammatory and degenerative magnetic resonance imaging (MRI) outcomes. Digital single-molecule array (Simoa) technology improves accuracy of bioassays in the quantification of neurofilament light chain (NfL) in serum and plasma. NfL seems to mark a common final path of neuroaxonal injury independent of specific causal pathways. CSF and blood levels of NfL are highly correlated across various diseases including MS, suggesting that blood measurements may be useful in assessing response to treatment and predicting future disease activity. Other biomarkers like matrix metalloproteinases, chemokines, or neurotrophic factors have not been studied to a similar extent. Such measures, especially in blood, need further validation to enter the trial arena or clinical practice. The broadening armamentarium of highly sensitive assay technologies in the future may shed even more light on patient heterogeneity and mechanisms leading to disability in MS. Evoked potentials (EPs) are used in clinical practice to measure central conduction of central sensorimotor pathways. They correlate with and predict the severity of clinical involvement of their corresponding function. Their validation for use in multicenter studies is still lacking, with the exception of visual EPs. If further validated, EPs and fluid biomarkers would represent useful outcome measures for clinical trials, being related to specific mechanisms of the ongoing pathologic changes.

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Event-related brain potential indices of cognitive function and brain resource reallocation during working memory in patients with Multiple Sclerosis

Cited by 36 publications

References 90 publications

Mobile Brain/Body Imaging of cognitive-motor impairment in multiple sclerosis: deriving EEG-based neuro-markers during a dual-task walking study

Mobile Brain/Body Imaging of cognitive-motor impairment in multiple sclerosis: deriving EEG-based neuro-markers during a dual-task walking study

Spatiotemporal and spectral dynamics of multi‐item working memory as revealed by the n‐back task using MEG

Fluid biomarker and electrophysiological outcome measures for progressive MS trials

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