Event-Related Brain Potentials in Elderly Dippers and Nondippers with Recently Diagnosed Hypertension

Cicconetti, P.; Ciotti, Veronica; Tafaro, Laura; Priami, Carolina; Chiarotti, Flavia; Costarella, Marianna; Piccirillo, Gianfranco; Cacciafesta, Mauro

doi:10.1291/hypres.27.581

Cited by 11 publications

(8 citation statements)

References 38 publications

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“…This finding replicates findings reported by other groups. 13 –15,24 The absence of a significant change in auditory or visual P300 amplitude associated with alcohol dependence is difficult to explain in the context of other studies that have detected such changes 12,25 . One explanation may be our unique approach of employing depression, smoking, and conduct problems as covariates.…”

Section: Discussionmentioning

confidence: 96%

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Interactive Effects of Hypertension and Alcohol Dependence on the P300 Event-Related Potential in African-Americans

2006

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Although hypertension and alcohol dependence have been linked by epidemiological surveys and clinical observations, their interactive effects on brain function have rarely been tested. The present study involved the recording of P300 event related potentials (ERP) from 106 middle-aged African-American adults assigned to one of four groups: normotensive/nondependent (n=56), hypertensive/nondependent (n=11), normotensive/dependent (n=27), and hypertensive/dependent (n=12). The numbers of Nicotine Dependence, Major Depressive Disorder, and Conduct Disorder symptoms were specified as covariates within a 2 by 2 factorial design. ERPs were recorded during separate visual and auditory oddball tasks. The major result was a synergistic effect of hypertension and alcohol dependence on auditory P300 latency: the combination of both factors was associated with greater slowing than the sum of their independent effects. Future studies should continue to examine the potential synergistic effects of alcohol dependence and hypertension with a view toward identifying and reducing neurophysiological decrements and stroke risk among middle-aged patients.

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Section: Discussionmentioning

confidence: 96%

“…Aberrant ERP component amplitudes and latencies have been extensively documented among alcohol dependent patients. 12 One persistent observation is a decrement in the amplitude of the P300 event-related potential. Abnormalities of P300 latency have also been reported in alcohol-dependent populations, 13 –15 albeit not as frequently.…”

Section: Introductionmentioning

confidence: 99%

Interactive Effects of Hypertension and Alcohol Dependence on the P300 Event-Related Potential in African-Americans

2006

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“…The implication of hypertension on the cognitive decline has varied results in the previous studies [5][6][7]. However, all the studies that used ERPs to evaluate cognitive dysfunction proved its effect with electrophysiological evidence [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Cognition in Hypertensives and Normotensives: A Comparative P300 Study

Gogisetti¹,

Pathania²,

Mittal³

et al. 2022

Cureus

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Background: Hypertension is an established risk factor for dementia, and the prevalence of hypertension and dementia is rising. Current tests to diagnose cognitive dysfunction at an early stage lack sensitivity and specificity. Recently event-related potentials (ERPs) have gained much attention in diagnosing cognitive dysfunction and are independent of the education status of the subject. This study was done to find any cognitive deficits in the hypertensive population with electrophysiological evidence, which might open the doors for the need to screen the population at an earlier stage so that the population can be prevented from dementia. Methods: Some 31 middle-aged (18-65 years) hypertensives were compared with 31 age, sex, education, and handedness matched normotensives about cognition by neuropsychometric test battery including Hindi Mini-mental Status Examination (HMSE), Hindi Montreal Cognitive Assessment (MoCA), choice reaction time (CRT), and auditory event-related potentials. Results: Hypertensives and normotensives differed significantly concerning P300 potentials’ latency (Fz and Cz P300 latencies: p-value: 0.001), and this change was correlated well with the duration of diastolic blood pressure (BP) (r-value: 0.670). The remaining tests, HMSE, Hindi MoCA, and CRT, were dependent on the education status of the patient. Conclusions: The effect of hypertension on cognitive impairment is evident and can be proved early in its pre-clinical stage using ERPs. Early identification can help in specifying high-risk individuals. ERPs have great potential in screening and diagnosing and can also help in assessing cognition as a reliable tool to show the effect of treatments/interventions on cognitive defects.

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“…Both nondipping and extreme dipping have shown to be associated with cerebrovascular disease (Shimada et al 1992;Kario et al 2001). Some studies have found nondipping to be a risk marker for cognitive impairment (Kilander et al 1998;van Boxtel et al 1998;Yamamoto et al 2005), while others have found no such association (Cicconetti et al 2004;van Boxtel et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Lower cognitive performance in 81-year-old men with greater nocturnal blood pressure dipping

Axelsson

Reinprecht²,

Siennicki-Lantz³

et al. 2008

IJGM

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Abnormal day-tonight blood pressure (BP) pattern have been found to be associated with cerebrovascular damage, yet studies of the elderly 80 years of age and above, for whom the risk pattern may be different due to ageing and age-associated diseases, are lacking. Ninetyseven 81-year-old men underwent ambulatory BP monitoring and were given six cognitive tests, 79 of the men completing the cognitive test battery. The odds ratio (OR) for performing one standard deviation below the mean on any cognitive test was calculated using a forward stepwise logistic regression model, confounding factors being controlled for. Groups defi ned in terms of day-tonight changes in BP were compared in this respect. Cognitive performance was lower (OR 3.6; P = 0.017) in the group usually described as dippers (10%-20% nocturnal drop in systolic BP [SBP]) as compared with nondippers (Ͻ10% drop). The tertile with the greatest SBP fall (10.6%-19.8%, a range considered as normal among middle aged) showed lowest cognitive performance (OR 4.7; P = 0.008) as compared with the middle tertile (5.1%-10.5% drop). The mean nocturnal fall in SBP was 7.4%, signifi cantly greater in those with lower rather than higher cognitive performance. A nocturnal drop in SBP of Ն10% was associated with lower cognitive performance in these elderly men. The limits to normal dipping appear to be shifted in the direction of a lesser drop in the very elderly.

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Event-Related Brain Potentials in Elderly Dippers and Nondippers with Recently Diagnosed Hypertension

Cited by 11 publications

References 38 publications

Interactive Effects of Hypertension and Alcohol Dependence on the P300 Event-Related Potential in African-Americans

Interactive Effects of Hypertension and Alcohol Dependence on the P300 Event-Related Potential in African-Americans

Assessment of Cognition in Hypertensives and Normotensives: A Comparative P300 Study

Lower cognitive performance in 81-year-old men with greater nocturnal blood pressure dipping

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