Event-related brain potentials reveal covert distractibility in closed head injuries

Kaipio, Marja Liisa; Alho, Kimmo; Winkler, István; Escera, Carles; Surma-aho, Outi; Näätänen, Risto

doi:10.1097/00001756-199907130-00024

Cited by 42 publications

(31 citation statements)

References 5 publications

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“…Other recent studies have reported findings of increased orienting P300 amplitude responses to both novel (Solbakk, Reinvang, Nielsen, & Sundet, 1999) and emotional (Kaipio et al, 1999) stimuli following head trauma. These observations are consistent with our findings.…”

Section: H a B I T U A T I O N A T P Zmentioning

confidence: 77%

Orbitofrontal cortex and dynamic filtering of emotional stimuli

Rule

Shimamura

Knight

2002

Cognitive, Affective, & Behavioral Neuroscience

139

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Event-related potentials (ERPs) were recorded in response to mildly aversive somatosensory and auditory stimuli. Patients with orbitofrontal lesions exhibited enhanced ERPs (i.e., P3 amplitudes), as compared with control subjects. Moreover, these patients did not habituate to somatosensory stimuli across blocks of trials. The results were specific to orbitofrontal damage, since patients with damage to the dorsolateral prefrontal cortex did not exhibit enhanced P3 amplitudes. These findings suggest that damage to the orbitofrontal cortex impairs the ability to modulate or inhibit neural responses to aversive stimuli. The findings are couched in terms of dynamic filtering theory, which suggests that the orbitofrontal cortex is involved in the selection and active inhibition of neural circuits associated with emotional responses.

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Section: H a B I T U A T I O N A T P Zmentioning

confidence: 77%

Orbitofrontal cortex and dynamic filtering of emotional stimuli

Rule

Shimamura

Knight

2002

Cognitive, Affective, & Behavioral Neuroscience

139

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“…In a study of patients with closed-head injuries, Kaipio et al [1999] reported MMNs to deviant tones similar to those in control subjects but an enhanced late subcomponent of P 3a to novel sounds, suggesting a 'normal' activation of the change detector mechanism associated with MMN but a stronger attention-switching response to large changes in the unattended acoustic environment. Consistently with this, Polo et al [1998] reported similar MMNs but enhanced P 3a responses to deviant tones in a group of chronic abstinent alcoholics.…”

Section: Use Of Erps In Clinical Research Of Involuntary Attention Anmentioning

confidence: 92%

Involuntary Attention and Distractibility as Evaluated with Event-Related Brain Potentials

Escera

Alho²,

Schröger³

et al. 2000

Audiol Neurotol

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613

524

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This article reviews recent event-related brain potential (ERP) studies of involuntary attention and distractibility in response to novelty and change in the acoustic environment. These studies show that the mismatch negativity, N₁ and P_3a ERP components elicited by deviant or novel sounds in an unattended sequence of repetitive stimuli index different processes along the course to involuntary attention switch to distracting stimuli. These studies used new auditory-auditory and auditory-visual distraction paradigms, which enable one to assess objectively abnormal distractibility in several clinical patient groups, such as those suffering from closed-head injuries or chronic alcoholism.

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“…Others (Heinze et al, 1992), however, including those in which it was quantified in the difference wave- Table 4 Closed head-injury effects on visual ERPs Sangal and Sangal (1996) Sangal and Sangal (1996) Polo et al (2002) Entries reflect comparisons between head-injury survivors and healthy controls. Kaipio et al (1999) Clark et al (1992) Packard and Ham (1996) Curry (1980 Keren et al (1998 Potter and Barrett (1999) Packard and Ham (1996) forms (Duncan et al, , 2005, have found significant reductions in visual N200 amplitude. Of the long latency components, P300 has been the most studied in investigations of head-injury survivors (Campbell and de Lugt, 1995).…”

Section: Amplitudementioning

confidence: 98%