Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users

Burgess, Adrian; Venables, Louise; Jones, Helena; Edwards, Rhiannon; Parrott, Andrew C.

doi:10.1007/s00213-011-2249-9

Cited by 25 publications

(25 citation statements)

References 38 publications

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“…Moreover, human abusers of MDMA exhibit deficits in verbal memory (Burgess et al, 2011; de Sola Llopis et al, 2008; Raj et al, 2010), and altered function of GABA interneurons in the hippocampus (Jacobsen et al, 2004). Further studies are warranted to investigate the hypothesis that MDMA-induced impairment of GABA interneurons in the hippocampus underlies the cognitive impairments associated with repeated exposure to MDMA.…”

Section: Discussionmentioning

confidence: 99%

MDMA Increases Glutamate Release and Reduces Parvalbumin-Positive GABAergic Cells in the Dorsal Hippocampus of the Rat: Role of Cyclooxygenase

Anneken

Cunningham

Collins

et al. 2012

J Neuroimmune Pharmacol

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3,4-Methylenedioxymethamphetamine (MDMA; Ecstasy) is a popular drug of abuse with well-documented acute effects on serotonergic, dopaminergic, and cholinergic transmitter systems, as well as evidence of long-term disruption of serotoninergic systems in the rat brain. Recently, it was demonstrated that MDMA evokes a delayed and sustained increase in glutamate release in the hippocampus. The purpose of the present study was to determine the role of inflammatory mediators in the MDMA-induced increase in glutamate release, as well as the contribution of inflammatory pathways in the persistent neurochemical toxicity associated with repeated MDMA treatment. Treatment with the non-selective cyclooxygenase (COX) inhibitor ketoprofen and the COX-2 selective inhibitor nimesulide attenuated the increase in extracellular glutamate in the hippocampus evoked by repeated MDMA exposure (10 mg/kg, i.p., every 2 h); no attenuation was observed in rats treated with the COX-1 selective inhibitor piroxicam. Reverse dialysis of a major product of COX activity, prostaglandin E2, also resulted in a significant increase in extracellular glutamate in the hippocampus. Repeated exposure to MDMA diminished the number of parvalbumin-positive GABA interneurons in the dentate gyrus of the hippocampus, an effect that was attenuated by ketoprofen treatment. However, COX inhibition with ketoprofen did not prevent the long-term depletion of 5-HT in the hippocampus evoked by MDMA treatment. These data are supportive of the view that cyclooxygenase activity contributes to the mechanism underlying both the increased release of glutamate and decreased number of GABA interneurons in the rat hippocampus produced by repeated MDMA exposure.

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Section: Discussionmentioning

confidence: 99%

MDMA Increases Glutamate Release and Reduces Parvalbumin-Positive GABAergic Cells in the Dorsal Hippocampus of the Rat: Role of Cyclooxygenase

Anneken

Cunningham

Collins

et al. 2012

J Neuroimmune Pharmacol

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“…Event Related Potentials (ERPs) are ideal for investigating tasks that require executive control, as these tasks require rapid executive decisions that are less detectable with other neuroimaging techniques. Burgess et al, (2011) observed differences between ecstasy users and controls in ERPs in a word recognition task. Ecstasy users showed an attenuation of a late positivity over left parietal scalp sites despite equivalent performance on the task.…”

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confidence: 84%

ERP evidence suggests executive dysfunction in ecstasy polydrug users

et al. 2013

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“…More recently, Burgess et al (2011) looked at ERPs as evidence for selective impairment of verbal recollection in currently abstinent recreational MDMA/polydrug users. Interestingly, there appeared to be no significant differences between ecstasy users, polydrug controls and drug naïve controls on the behavioural tasks (memory tasks which involved recognition of words and faces).…”

Section: Eeg Studies In Ecstasy Usersmentioning

confidence: 99%

“…Inhibitory control and set switching appear to be more robust to ecstasy-related deficits: however recent research in ecstasy users suggests that even in the absence of behavioural differences, ecstasy users may show electrophysiological differences related to task demands (Burgess et al, 2011). Such paradoxical effects can be seen in the implicit cognition literature where heavy drug users can show altered electrophysiological responses to drug stimuli in the absence of behavioural differences (Petit et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological indices of response inhibition in human polydrug users

et al. 2013

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Previous research in ecstasy users suggests impairment of various executive functions. In general, the executive function of response inhibition appears unaffected by ecstasy use. Nonetheless, it remains a possibility that cognitive tasks alone are not sensitive enough to pick up subtle changes in function. The current study sought to investigate behavioural measures of response inhibition and their electrophysiological correlates in drug users. Twenty ecstasy polydrug users, 20 non-ecstasy polydrug users and 20 drug naïve controls were recruited. Participants completed questionnaires about their background drug use, sleep quality, fluid intelligence and mood state. Each individual also completed a Go/NoGo response inhibition task whilst electroencephalography (EEG) measures were recorded. Analysis of variance (ANOVA) revealed that there were no between-group differences on the behavioural measure of response inhibition. Multivariate analysis of variance (MANOVA) revealed no main effect of group across midline electrodes for the P3, N2 and P2 components. Univariate ANOVA revealed significant between-group differences in the P2 component with the ecstasy user group having a significantly higher mean amplitude than drug naïve controls at two midline frontal electrodes: at Fz and significantly higher mean amplitude than both control groups at FCz. The present study provides evidence of atypical early processing in ecstasy users that is suggestive of compensatory mechanisms ameliorating any behavioural differences.

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Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users

Cited by 25 publications

References 38 publications

MDMA Increases Glutamate Release and Reduces Parvalbumin-Positive GABAergic Cells in the Dorsal Hippocampus of the Rat: Role of Cyclooxygenase

MDMA Increases Glutamate Release and Reduces Parvalbumin-Positive GABAergic Cells in the Dorsal Hippocampus of the Rat: Role of Cyclooxygenase

ERP evidence suggests executive dysfunction in ecstasy polydrug users

Electrophysiological indices of response inhibition in human polydrug users

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