Event-related potentials associated to N-back test performance in schizophrenia

Arjona, Antonio; Fondevila-Estévez, Sabela; Fernández-Linsenbarth, Inés; Díez, Álvaro; Ruiz-Sanz, Francisco Javier; Rodríguez-Lorenzana, Alberto; Molina, Vicente

doi:10.1016/j.pnpbp.2021.110347

Cited by 6 publications

(3 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Deficits in N100 sensory gating were correlated to worse problem-solving abilities [ 154 ], attention [ 149 ] and working memory [ 149 ] in SCZ. However, the association between N100 amplitude and cognitive functions in SCZ is not clear since some studies reported a correlation between N100 amplitude and different cognitive abilities, such as verbal and visual memory [ 159 , 163 ], executive functioning [ 153 ], attention [ 201 ] and general cognition [ 153 ], while other studies did not find a significant correlation between N100 amplitude and attention [ 147 , 155 , 156 ], visual learning and memory [ 146 , 147 , 157 , 162 ], verbal learning and memory [ 160 , 161 ], executive functioning [ 147 , 161 , 162 , 197 ], working memory [ 164 ] or attention to stimuli related to social scenarios [ 158 ].…”

Section: Resultsmentioning

confidence: 99%

“…Investigations on correlations between cognitive functions and ERPs related to early sensory processing, such as P50, N100 and P100 led to discrepant results. However, most studies showed an association between these ERPs and several cognitive functions, such as attention, memory, learning, problem solving and executive functions [ 144 , 145 , 146 , 149 , 150 , 153 , 154 , 155 , 159 , 163 , 165 , 201 ]. It has been hypothesized that dysfunctions in auditory and visual sensory processing, as flagged by blunted amplitude of these EPRs, could derive from abnormalities in frontal and temporal regions and might contribute to impairments in higher-order cognitive functions [ 144 , 145 , 146 , 159 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

Cognitive dysfunctions represent a core feature of schizophrenia-spectrum disorders due to their presence throughout different illness stages and their impact on functioning. Abnormalities in electrophysiology (EEG) measures are highly related to these impairments, but the use of EEG indices in clinical practice is still limited. A systematic review of articles using Pubmed, Scopus and PsychINFO was undertaken in November 2021 to provide an overview of the relationships between EEG indices and cognitive impairment in schizophrenia-spectrum disorders. Out of 2433 screened records, 135 studies were included in a qualitative review. Although the results were heterogeneous, some significant correlations were identified. In particular, abnormalities in alpha, theta and gamma activity, as well as in MMN and P300, were associated with impairments in cognitive domains such as attention, working memory, visual and verbal learning and executive functioning during at-risk mental states, early and chronic stages of schizophrenia-spectrum disorders. The review suggests that machine learning approaches together with a careful selection of validated EEG and cognitive indices and characterization of clinical phenotypes might contribute to increase the use of EEG-based measures in clinical settings.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“… 23 The sensitivity of N1 components to attention has been noted. 24 The P2 component of the brain's electrical activity has been associated with working memory and classification processes, and its fluctuations are linked to the specific tasks that are being performed. 25 The N170 component is widely recognized as a characteristic feature of face specificity.…”

Section: Methodsmentioning

confidence: 99%

Acousto-optic stimuli to promote coherent 40-Hz frequency entrainment effect

Han,

Wang,

Yang

2023

Arq Neuropsiquiatr

View full text Add to dashboard Cite

Background Research has shown that a fundamental frequency of 40 Hz in continuous neural oscillation is indicative of normal brain activity; in Alzheimer disease (AD) patients, these oscillations either disappear or are significantly interrupted. Research has also indicated that the degenerative impacts of AD in mice were mitigated by the synchronization of 40-Hz acousto-optic stimulation (AOS). Objective To examine the impact of employing a 40-Hz AOS intervention on the induction of a substantial 40-Hz frequency entrainment and improvement in working memory performance among a sample of young individuals in good health. We conduct an analysis of event-related potentials (ERPs) derived from electroencephalogram (EEG) data following the presentation of AOS. Methods We recruited 20 healthy volunteers (median age: 25 years; 8 female subjects). Following the administration of various stimuli, including no stimuli, 40-Hz AOS, pink noise, and 40Hz acoustic stimuli (AS), the participants were required to complete a working memory task. A total of 62 electrodes were used to record EEG data, which was subsequently analyzed to investigate the impact of AOS on the activity of working memory. We also aimed to determine if AOS lead to a more pronounced 40-Hz frequency entrainment. Results Following the administration of AOS, a notable enhancement in the 40-Hz power of pertinent cerebral areas was observed, accompanied by a substantial improvement in the performance of the subjects on working memory tests subsequent to the stimulation. Conclusion The findings unequivocally establish the efficacy of using AOS to enhance the 40-Hz power and working memory.

show abstract