Everlasting flowers: Phytochemistry and pharmacology of the genus Helichrysum

Akaberi, Maryam; Sahebkar, Amirhossein; Azizi, Narjes; Emami, Seyed Ahmad

doi:10.1016/j.indcrop.2019.111471

Cited by 49 publications

(48 citation statements)

References 144 publications

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“…Compound Class/Name EE DCME ACNE 2',3'-dihydroxypuberulin [31] + 7-(2,3-dihydroxy-3-methylbutoxy)-5-hydroxy-6-methoxy-2H-1-benzopyran-2-one [32] + + coumarin derivative [33,34] [37] + italipyrone [22] + italipyrone analog [22] + γ-pyrone (chromone) 3-(acetyloxy)-2,3-dihydro-5,7-dihydroxy-6-(3-methyl-2-butenyl)-2-phenyl-4H-1-benzopyran-4-one [38] + 2,3-dihydro-5,7-dihydroxy-3-methyl-8-(3-methyl-2-butenyl)-2-(1-methylethyl)-4H-1-benzopyran-4-one [39] + Flavonoid flavone apigenin-7-O-glucoside [4] + apigenin-5-O-glucoside [40] + luteolin [41] + 3,5,6,7,8-pentamethoxyflavone [42] + 3',4',5,6,7-pentamethoxyflavone [43] + apigenin [40] + dihydroxy-dimethoxyflavone [44] + jaceosidin [45] + chrysoeriol [45] + 5,7-dihydroxy-3-methoxyflavone [44] + 5,7,4'-trihydroxy-3,6-dimethoxy-3'-prenylflavone [46] + TEDMF 1 [43] [43] + flavanone naringenin-5-O-glucoside [40] + naringenin-4 -O-glucoside [48] + naringenin-7-O-glucoside [40] + eriodictyol [49] + naringenin [40] + + flavonol quercetin-3-O-glucoside [4], hyperoside (quercetin-3-O-galactoside) [4] + kaempferol-3-O-glucoside [50] + Table 1. Cont.…”

Section: Nomentioning

confidence: 99%

“…Plicatipyrone (10) was previously isolated from this species [22]. Akaberi et al [1] listed several different groups of α-pyrone derivatives that are distributed in Helichrysum spp., namely monomers, glycosylated forms, homo-, and heterodimers. The α-pyrone profile tentatively determined in H. plicatum in the present study corresponds to α-pyrones found in other Helichrysum species.…”

Section: Phytochemical Profilementioning

confidence: 99%

“…The genus Helichrysum Miller (Asteraceae) comprises about 600 species of perennial or annual herbs or shrublets distributed in Europe, Asia, and Africa, the plant parts of which have been traditionally used as infusions or decoctions in the treatment of diverse ailments [1,2]. Interest in phytochemical and pharmacological studies of this genus has increased in recent years.…”

Section: Introductionmentioning

confidence: 99%

“…Interest in phytochemical and pharmacological studies of this genus has increased in recent years. Helichrysum species represent an abundant source of secondary metabolites, such as flavonoids, chalcones, phenolic acids, phthalides, coumarins, pyrones, and terpenes [1]. Plant extracts and their chemical constituents exhibit a range of biological activities, including antioxidant, anti-inflammatory, wound-healing, antimicrobial, photoprotective, anticarcinogenic, etc.…”

Section: Introductionmentioning

confidence: 99%

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Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

Vujić

Vidaković

Jadranin

et al. 2020

Plants

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Helichrysum plicatum DC. is widely used in folk medicine in treating a variety of health disorders. The aim of this study was to examine the influence of different extraction solvents on the chemical composition, antioxidant potential, and antimicrobial activities of H. plicatum. Aerial parts were separately extracted with ethanol, dichloromethane, and sunflower oil. The oil extract (OE) was re-extracted with acetonitrile. A total of 142 compounds were tentatively identified in ethanolic (EE), dichloromethane (DCME), and acetonitrile (ACNE) extracts using HPLC-DAD/ESI-ToF-MS. The dominant compound class in all extracts were α-pyrones, alongside flavonoids in EE, terpenoids in DCME and ACNE, and phloroglucinols in DCME. The antioxidant potential of the extracts was assessed by the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) assay. EE and DCME possessed the most potent radical scavenging capacity. Antimicrobial activity was investigated on eight bacterial, two yeast, and one fungal species. All extracts exhibited high antifungal and notable antibacterial activities compared to control substances, with DCME being the most potent. DCME exhibited stronger antimicrobial activity against P. aeruginosa than the standard chloramphenicol.

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Section: Nomentioning

confidence: 99%

Section: Phytochemical Profilementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

Vujić

Vidaković

Jadranin

et al. 2020

Plants

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“…This species is well distributed in South Africa and neighboring African countries, including Lesotho, Swaziland, Mozambique, and Zimbabwe (Swelankomo, 2004). This species has a plethora of traditional uses in the treatment of wounds, burns, eczema, and as an ointment for pimples (Hutchings et al, 1996;Akaberi et al, 2019). H. odoratissimum is among one of the most popular species within the Helichrysum genus and has been traditionally used as an application for pimples and to treat other skin dermatoses, however, it was yet to be tested for its antimicrobial activity against C. acnes (Hutchings et al, 1996;Lourens et al, 2011;Mabona and Van Vuuren, 2013).…”

Section: Introductionmentioning

confidence: 99%

Exploring the Anti-Acne Potential of Impepho [Helichrysum odoratissimum (L.) Sweet] to Combat Cutibacterium acnes Virulence

et al. 2020

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The Gram-positive bacterium Cutibacterium acnes (previously Propionibacterium acnes), plays an important role in the pathogenesis and progression of the dermatological skin disorder acne vulgaris. The methanolic extract of Helichrysum odoratissimum (L.) Sweet (HO-MeOH) was investigated for its ability to target bacterial growth and pathogenic virulence factors associated with acne progression. The gas chromatography-mass spectrometry (GC-MS) analysis of HO-MeOH identified a-humulene (3.94%), acurcumene (3.74%), and caryophyllene (8.12%) as major constituents, which correlated with previous reports of other Helichrysum species. The HO-MeOH extract exhibited potent antimicrobial activity against C. acnes (ATCC 6919) with a minimum inhibitory concentration (MIC) of 7.81 µg/ml. It enhanced the antimicrobial activity of benzoyl peroxide (BPO). The extract showed high specificity against C. acnes cell aggregation at sub-inhibitory concentrations, preventing biofilm formation. Mature C. acnes biofilms were disrupted at a sub-inhibitory concentration of 3.91 µg/ml. At 100 µg/ml, HO-MeOH reduced interleukin-1a (IL-1a) cytokine levels in C. acnes-induced human keratinocytes (HaCaT) by 11.08%, highlighting its potential as a comedolytic agent for the treatment of comedonal acne. The extract exhibited a 50% inhibitory concentration (IC 50 ) of 157.50 µg/ ml against lipase enzyme activity, an enzyme responsible for sebum degradation, ultimately causing inflammation. The extract's anti-inflammatory activity was tested against various targets associated with inflammatory activation by the bacterium. The extract inhibited pro-inflammatory cytokine levels of IL-8 by 48.31% when compared to C. acnes-induced HaCaT cells at 7.81 µg/ml. It exhibited cyclooxygenase-II (COX-II) enzyme inhibition with an IC 50 of 22.87 µg/ml. Intracellular nitric oxide (NO) was inhibited by 40.39% at 7.81 µg/ml when compared with NO production in lipopolysaccharide (LPS)induced RAW264.7 cells. The intracellular NO inhibition was potentially due to the 2.14 fold reduction of inducible nitric oxide synthase (iNOS) gene expression. The HO-MeOH extract exhibited an IC 50 of 145.45 µg/ml against virulent hyaluronidase enzyme activity, Frontiers in Pharmacology | www.frontiersin.org January 2020 | Volume 10 | Article 1559 1 which is responsible for hyaluronan degradation and scar formation. This study provides scientific validation for the traditional use of H. odoratissimum as an ointment for pimples, not only due to its ability to control C. acnes proliferation but also due to its inhibitory activity on various targets associated with bacterial virulence leading to acne progression.

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P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants

Ortíz

Šavikin

Massicot

et al. 2023

Chemistry & Biodiversity

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Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti‐inflammatory in European folk medicine by the YO‐PRO‐1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl‐iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti‐inflammatory mechanism of cinnamoyl‐iridoids bearing plants, which may involve the P2X7 receptor.

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Everlasting flowers: Phytochemistry and pharmacology of the genus Helichrysum

Cited by 49 publications

References 144 publications

Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

Exploring the Anti-Acne Potential of Impepho [Helichrysum odoratissimum (L.) Sweet] to Combat Cutibacterium acnes Virulence

P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants

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