Evernia prunastri and Pseudoevernia furfuraceae lichens and their major metabolites as antioxidant, antimicrobial and anticancer agents

Kosanić, Marijana; Manojlović, N.; Janković, Slobodan M.; Stanojković, Tatjana; Ranković, Branislav

doi:10.1016/j.fct.2012.11.034

Cited by 149 publications

(156 citation statements)

References 25 publications

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“…In the literature there are no data on the anticancer activity of C. islandica, but anticancer activities of some other lichens have been studied. Kosanić et al (2013) reported significant anticancer effect for Evernia prunastri and Pseudoevernia furfuraceae. Manojlović et al (2010b) explored anticancer properties of Thamnolia vermicularis.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities of lichen Cetraria islandica

et al. 2014

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In this study, the antioxidant, antimicrobial, genotoxic and anticancer activities of Cetraria islandica methanol extract were determined by using free radical and superoxide anion scavenging activity, reducing power, determination of total phenolic compounds and flavonoid contents, broth microdilution minimal inhibitory concentration against five bacterial and five fungal species, cytokinesis block micronucleus (MN) assay on peripheral blood lymphocytes (PBLs) and the microculture tetrazolium test on FemX (human melanoma) and LS174 (human colon carcinoma) cell lines. As a result of the study, we found that C. islandica methanol extract exhibited moderate free-radical-scavenging activity with IC 50 values 678.38 lg/ml. Moreover, the tested extract had effective reducing power and superoxide anion radical scavenging. The minimal inhibitory concentration values against the tested microorganisms ranged from 0.312 to 5 mg/ml. The extract increased MN frequency in a dose dependent manner, but it was significant in higher tested concentrations (50, 100 and 200 lg/ml). No significant differences were observed between NDI values in all treatments and untreated PBLs. In addition, the tested extract had strong anticancer activity towards both cell lines with IC 50 values of 22.68 and 33.74 lg/ml. It can be concluded that the tested extract exhibited a certain level of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities.

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Section: Resultsmentioning

confidence: 99%

Evaluation of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities of lichen Cetraria islandica

et al. 2014

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“…As a result of examination of DPPH and superoxide anion capture and reducing power activities of PHA, it was detected that PHA metabolite had high antioxidant capacity (Kosanić & Ranković 2011;Kosanić et al 2013;Ranković et al 2014). Furthermore, it was reported that PHA that showed antimutagenic effect inhibiting the formation of reactive metabolites (Osawa et al 1991) possessed antimicrobial activity (Yilmaz et al 2005;Kosanić & Ranković 2011;Kosanić et al 2013;Ranković et al 2014) if it was used at certain concentrations. In recent years, cytotoxic effects of PHA tested toxicity on microorganisms were evaluated on different cells.…”

Section: Discussionmentioning

confidence: 99%

“…They were reported to be effective in the treatment some diseases such as tuberculosis (Vartia 1973), hemorrhoids and dysentery (Dülger et al 1998). Furthermore, antibacterial (Kosanić & Ranković 2011;Kosanić et al 2013Kosanić et al , 2014Grujičić et al 2014), antiviral (Karagöz & Aslan 2005), antiinflammatory (Süleyman et al 2002(Süleyman et al , 2003Halici et al 2005;Odabasoglu et al 2006), antioxidant (Gülçin et al 2002;Aslan et al 2006;Paudel et al 2012;Ghate et al 2013;Grujičić et al 2014), antimutagenic and antigenotoxic activities (Zeytinoglu et al 2008;Agar et al 2010;Alpsoy et al 2011;Kotan et al 2011) of the lichens were reported.…”

Section: Introductionmentioning

confidence: 99%

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In vitroantitumor activities of the lichen compounds olivetoric, physodic and psoromic acid in rat neuron and glioblastoma cells

Emsen

Aslan

Toğar

et al. 2015

Pharmaceutical Biology

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Context Since methods utilised in the treatment of glioblastoma multiforme (GBM) are inadequate and have too many side effects, usage of herbal products in the treatment process comes into prominence. Lichens are symbiotic organisms used for medicinal purposes for many years. There are various anticancer treatments about components of two lichen species used in the present study. Objective Antitumor potential of three lichen secondary metabolites including olivetoric acid (OLA) and physodic acid (PHA) isolated from Pseudevernia furfuracea (L.) Zopf (Parmeliaceae) and psoromic acid (PSA) isolated from Rhizoplaca melanophthalma (DC.) Leuckert (Lecanoraceae) were investigated on human U87MG-GBM cell lines and primary rat cerebral cortex (PRCC) cells for the first time. Materials and methods PRCC cells used as healthy brain cells were obtained from SpragueDawley rats. The treatments were carried out on the cells cultured for 48 h. Cytotoxic effects of different concentrations (2.5, 5, 10, 20 and 40 mg/L) of metabolites on the cells were determined via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) analyses. Total antioxidant capacity (TAC) and total oxidant status (TOS) parameters were used for assessing oxidative alterations. Oxidative DNA damage potentials of metabolites were investigated via evaluating 8-hydroxy-2 0 -deoxyguanosine (8-OH-dG) levels. Results Median inhibitory concentration (IC 50 ) values of OLA, PHA and PSA were 125.71, 698.19 and 79.40 mg/L for PRCC cells and 17.55, 410.72 and 56.22 mg/L for U87MG cells, respectively. It was revealed that cytotoxic effects of these metabolites showed positive correlation with concentration, LDH activity and oxidative DNA damage. Discussion and conclusion The present findings obtained in this study revealed that primarily OLA and then PSA had high potential for use in the treatment of GBM. ARTICLE HISTORY

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“…Genellikle asit bileşikleri olmalarından dolayı "liken asitleri" olarak da adlandırılan bu liken maddeleri sayesinde likenler antibakteriyel, antifungal, antiviral, antioksidan ve antitümör gibi çeşitli biyolojik aktiviteler gösterirler (8)(9)(10) . Liken sekonder metabolitlerinin hem Gram pozitif hem de Gram negatif bakterilere karşı antibakteriyel etkinlikleri, son zamanlarda literatürde yer alan çok sayıda çalışma ile kanıtlanmıştır (11)(12)(13).…”

Section: Introductionunclassified

Antibacterial Activities of Extracts of Lichen Samples Collected from Balikesir Region on Escherichia coli ATCC 25922

Uçarkuş¹,

Gökalsın²,

Yildirim³

et al. 2017

TMCD

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Evernia prunastri and Pseudoevernia furfuraceae lichens and their major metabolites as antioxidant, antimicrobial and anticancer agents

Cited by 149 publications

References 25 publications

Evaluation of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities of lichen Cetraria islandica

Evaluation of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities of lichen Cetraria islandica

In vitroantitumor activities of the lichen compounds olivetoric, physodic and psoromic acid in rat neuron and glioblastoma cells

Antibacterial Activities of Extracts of Lichen Samples Collected from Balikesir Region on Escherichia coli ATCC 25922

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