Evidence Against a Contralateral Coats Phenotype by Optical Coherence Tomography Angiography

Daruich, Alejandra; Zola, Marta; Elalouf, Martine; Munier, Francis L.

doi:10.1097/iae.0000000000003438

Cited by 3 publications

(8 citation statements)

References 12 publications

(23 reference statements)

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“…There are a number of trials that suggest that changes related to FD could progress from the DCP in early disease stages to the SCP in later stages. 9,10 Although the number of cases in our study were small for individual disease stage cohorts, absolute differences in superficial and deep FD between fellow Coats eyes and control eyes seem to be greater in stage 2A than in stage 2B, which may support this assumption.…”

Section: Discussionmentioning

confidence: 66%

“…However, in stages 1 and 2A, these changes were only observed in the DCP. 10 In their comparative analysis of fellow eyes of Coats patients with healthy control eyes, the authors neither report any differences for FAZ, nor for FD parameters.…”

Section: Discussionmentioning

confidence: 89%

“…The publications that have elaborated on quantitative changes in Coats disease using OCTA have yielded inconsistent results. Although some authors report Coats disease to cause quantifiable changes in FD in affected eyes only, 9,10 others have described changes in fellow eyes, questioning the traditional view that Coats disease manifests unilaterally. 8 The primary aim of this study is to examine and quantify changes in OCTA derived parameters of the macula in both eyes of patients with Coats disease in comparison to one another and in comparison to healthy control eyes.…”

mentioning

confidence: 98%

“…5 To date, only a limited number of studies have investigated capillary changes in patients with Coats disease using OCTA. [6][7][8][9][10] A large portion of the available literature on OCTA imaging in Coats disease is limited to case series investigating a small number of patients each, which is mainly because of the rareness of the disease. [11][12][13][14][15] Consequently, many of these publications have been limited to qualitative descriptions of structural changes observed in en face OCTA scans.…”

mentioning

confidence: 99%

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Further Evidence Against Bilateral Manifestation Of Coats Disease In Optical Coherence Tomography Angiography of the Macula

Storp¹,

Leclaire²,

Zimmermann³

et al. 2023

Retina

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Purpose:Recent studies have questioned the traditional view, which regards Coats disease as a strictly unilateral entity. Applying optical coherence tomography angiography, this prospective, monocentric study investigates quantitative capillary changes of the macula associated with Coats disease.Methods:Twenty-four eyes (4 untreated, 8 pre-treated) of 12 patients with stage 2 Coats disease (age range: 9–61 years) and 15 eyes of healthy, age-matched controls from the University of Muenster Medical Center, Germany received macular optical coherence tomography angiography measurements of the superficial, deep, and choriocapillary capillary plexus. Flow density and parameters related to the foveal avascular zone were compared between Coats eyes and fellow eyes, and between fellow eyes and control eyes. Additional subanalyses investigated changes based on disease stage.Results:Flow density did not differ between fellow eyes of Coats disease patients and control eyes in any of the parameters investigated. Comparison of Coats eyes to their respective fellow eyes revealed Coats disease to be associated with lower flow density in superficial, deep, and choriocapillary capillary plexus regions, irrespective of disease stage (all P < 0.03). There were no noticeable differences regarding the size or symmetry of the foveal avascular zone.Conclusion:In light of the recent discussion around the unilateral character of Coats disease, this trial provides evidence against a bilateral presentation of vascular changes in the macula.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 98%

mentioning

confidence: 99%

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Further Evidence Against Bilateral Manifestation Of Coats Disease In Optical Coherence Tomography Angiography of the Macula

Storp¹,

Leclaire²,

Zimmermann³

et al. 2023

Retina

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“…Previous studies have demonstrated that this condition is typically unilateral, and the fellow eye appears normal upon examination with optical coherence tomography (OCT). [17].…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Visual Outcomes in Coats’ Disease in Mexican Population: a multicenter study

Carranza-Casas

Astorga-Carballo

Saucedo-Castillo

et al. 2023

Preprint

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Purpose To report clinical findings and final visual acuity outcomes in patients with Coats disease (CD) treated in central Mexico. Methods Retrospective case series analysis of CD patients recruited from five referral hospitals. Clinical characteristics that included age and symptoms at diagnosis, the area of retinal affected, treatment modalities and visual outcomes were recorded. Age of presentation and retinal zones involved were evaluated based on final visual outcomes. Results 67 eyes (66 patients) with diagnosis of CD were identified. Male gender occurred in 81% and the right eye was affected in 55% of the cases. Mean age at diagnosis was 11 years (median 9.8, range 6 months to 65 years). Only 9 patients (13%) had initial visual acuity (VA) better than 1.3 logMAR. Twenty patients received more than one treatment modality and laser photocoagulation was the most widely used. Final VA was classified as blindness in 57 (85%) patients, and it was correlated with worse initial visual acuity (p = 0.005). Number and extension of affected retinal zones were not correlated with age of presentation or gender (p > 0.05). During a mean follow-up of 42 months (SD +/- 37.8), there was slight improvement in visual acuity after treatment in only three cases (4.5%). Conclusion Final visual acuity in almost all CD patients was severe visual impairment. Visual prognosis is poor and depends on stage, location of disease and age of presentation. New strategies for early CD diagnosis by novel methods are needed to improve visual outcomes in these patients.

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Vascular abnormalities in fellow eyes of patients with unilateral coats’ disease

Lee,

Kim,

Kang

et al. 2023

Sci Rep

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Coats’ disease is an idiopathic retinal vascular disorder, known to usually occur unilaterally; however, recent studies have highlighted vascular abnormalities in the fellow unaffected eyes. This retrospective study investigated the peripheral vascular features and macular vascular structure of unaffected fellow eyes in patients with unilateral Coats’ disease using multimodal imaging tools. We analysed images of patients, including bilateral ultra-widefield imaging, fluorescein angiography (FA), ultra-widefield FA, or standard fundus photography. Available bilateral optical coherence tomography angiography (OCT-A) images were used for macular vascular structure analysis. OCT-A parameters, including foveal avascular zone (FAZ), perfusion index, and vessel density (VD) in the superficial and deep capillary plexuses (SCP, DCP), were calculated using Image J software. The mean age at diagnosis was 34.5 ± 17.9 years. The mean final best-corrected visual acuity of the affected eyes was logMAR 0.78 ± 0.79, while that of the fellow eyes was logMAR 0.04 ± 0.12. Ten fellow eyes had microaneurysms (47.6%), two had tortuous vessel abnormalities (9.5%), and 11(52.4%) had abnormal vascular findings on FA. Although there was a trend towards larger DCP FAZ (1.201 ± 0.086 vs. 1.072 ± 0.226), and lower DCP VD (8.593 ± 1.583 vs. 10.827 ± 3.392) in the affected eyes as measured by the Cirrus machine, the difference was not statistically significant between affected and fellow eyes when measured using the Zeiss Cirrus machine (P = 0.686, P = 0.343, respectively). However, when measured with the Spectralis machine, DCP FAZ was larger in affected eyes (0.828 ± 0.426 vs. 0.254 ± 0.092, P = 0.002) and DCP VD was lower in affected eyes (6.901 ± 2.634 vs. 17.451 ± 7.207, P = 0.002) compared to the fellow eyes, while other parameters showed no significant variations. These findings indicate that there may be subtle vascular abnormalities primarily located in the peripheral regions of the unaffected fellow eyes in patients with unilateral Coats’ disease, while the macular microvasculature remains unaffected.

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Evidence Against a Contralateral Coats Phenotype by Optical Coherence Tomography Angiography

Cited by 3 publications

References 12 publications

Further Evidence Against Bilateral Manifestation Of Coats Disease In Optical Coherence Tomography Angiography of the Macula

Further Evidence Against Bilateral Manifestation Of Coats Disease In Optical Coherence Tomography Angiography of the Macula

Clinical Features and Visual Outcomes in Coats’ Disease in Mexican Population: a multicenter study

Vascular abnormalities in fellow eyes of patients with unilateral coats’ disease

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