Evidence against acetone-soluble renin inhibitors in normal human plasma.

Druilhet, Robert E.; Overturf, M. L.; Hinshaw, Rex A.; Kirkendall, Walter M.

doi:10.1161/01.hyp.1.2.98

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…This finding was consistent with the results in a previous study that acetone injections lowered the blood pressure in cats and rabbits [20]. The reduced blood pressure by acetone exposure may be from the nephritic system effect [21].…”

Section: Discussionsupporting

confidence: 93%

Exposure to Indoor Volatile Organic Compounds and Hypertension among Thin Film Transistor Liquid Crystal Display Workers

et al. 2020

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This cross-sectional study aimed to determine the concentration of indoor volatile organic compounds (VOCs) and to investigate the association between indoor VOCs exposure and the prevalence of hypertension among thin film transistor liquid crystal display (TFT-LCD) workers. A total of 20 canisters were used to collect VOCs samples in the array, cell and module areas over 12 hours and VOCs concentrations were analyzed by the gas chromatography with mass spectrum. Individual information of health examination and lifestyles by self-administrated questionnaire were provided by 155 volunteers. The multivariate regression models were used to evaluate the associations between VOCs exposure, blood pressure and the prevalence of hypertension. The four dominant VOCs were ethanol (1870.8 ± 1754.0 ppb), acetone (689.9 ± 587.4 ppb), isopropyl alcohol (177.1 ± 202.3 ppb) and propylene glycol monomethyl ether acetate (98.2 ± 100.8 ppb), which were identified with the highest level in the module area for ethanol and acetone and in the array area for the others. Subjects exposed to a total level of ethanol, cyclohexanone and toluene ≥ 2500 ppb had an increased systolic blood pressure of 5.95 mmHg (95% confidence interval: 0.20–11.71; p = 0.043) compared with those exposed to <2500 ppb. Exposure to mixed VOCs in the indoor environment might be associated with elevated blood pressure among TFT-LCD workers.

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Section: Discussionsupporting

confidence: 93%

Exposure to Indoor Volatile Organic Compounds and Hypertension among Thin Film Transistor Liquid Crystal Display Workers

et al. 2020

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“…Also, some other studies showed that chronic exposure to acetone and tetrachloroethylene may be related to blood pressure due to nephritic system effect [Druilhet et al, 1979; Mutti et al, 1992].…”

Section: Introductionmentioning

confidence: 99%

Combined effects of exposure to occupational noise and mixed organic solvents on blood pressure in car manufacturing company workers

Attarchi

Golabadi

Labbafinejad

et al. 2012

American J Industrial Med

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“…Nevertheless, a variety of substances have been demonstrated to inhibit the activity of renin in vitro: in particular, a lysophospholipid of renal origin (Smeby & Bumpus, 1971); fatty acids (Druilhet, Overturf, Hinshaw & Kirkendall, 1979); proteins and peptides Scharpe, Eid, Cooreman & Lauwers, 1976).…”

Section: Discussionmentioning

confidence: 99%

“…The demonstration of apparently inactive forms of the enzyme renin (EC 3.4.99.19), reviewed by Overturf, Druilhet & Kirkendall (1979), provides considerable support for the existence of inactive precursors or of renin-inhibitor complexes.…”

Section: Introductionmentioning

confidence: 99%

Properties of a Renin Inhibitor Isolated from the Pig Kidney Cortex

Sagnella

Peart

1981

Clinical Science

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1. A renin-inhibitory material has been partially purified from soluble extracts of the pig kidney cortex by ammonium sulphate precipitation and diethylaminoethylcellulose (DEAE) chromatography and its properties studied. 2. It displayed competitive type kinetics. It did not inhibit cathepsin D, carboxypeptidase A, pancreatic kallikrein or trypsin. 3. Renins from dogs, rabbit and rat were inhibited, but not those from sheep or man, when assayed with pig angiotensinogen. 4. The material was inactivated by treatment with trypsin, N-ethylmaleimide or p-chloromercuribenzoate. 5. Renin-inhibitory activity was not found in plasma from peripheral blood of pigs. 6. It is concluded that the function of the renin inhibitor in the renal cortex of the pig may be restricted to the intrarenal environment.

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Evidence against acetone-soluble renin inhibitors in normal human plasma.

Cited by 5 publications

References 17 publications

Exposure to Indoor Volatile Organic Compounds and Hypertension among Thin Film Transistor Liquid Crystal Display Workers

Exposure to Indoor Volatile Organic Compounds and Hypertension among Thin Film Transistor Liquid Crystal Display Workers

Combined effects of exposure to occupational noise and mixed organic solvents on blood pressure in car manufacturing company workers

Properties of a Renin Inhibitor Isolated from the Pig Kidney Cortex

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