Evidence-Based Clinical Practice Guidelines on Regenerative Medicine Treatment for Chronic Pain: A Consensus Report from a Multispecialty Working Group

D'Souza, Ryan; Her, Yeng; Hussain, Nasir; Karri, Jay; Schatman, Michael; Calodney, Aaron; Lam, Christopher; Buchheit, Thomas; Boettcher, Brennan; Chang Chien, George; Pritzlaff, Scott; Centeno, Christopher; Shapiro, Shane; Klasova, Johana; Grider, Jay; Hubbard, Ryan; Ege, Eliana; Johnson, Shelby; Epstein, Max; Kubrova, Eva; Ramadan, Mohamed Ehab; Moreira, Alexandra; Vardhan, Swarnima; Eshraghi, Yashar; Javed, Saba; Abdullah, Newaj; Christo, Paul; Diwan, Sudhir; Hassett, Leslie; Sayed, Dawood; Deer, Timothy

doi:10.2147/jpr.s480559

JPR

2024

DOI: 10.2147/jpr.s480559

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Evidence-Based Clinical Practice Guidelines on Regenerative Medicine Treatment for Chronic Pain: A Consensus Report from a Multispecialty Working Group

Ryan D'Souza,

Yeng Her,

Nasir Hussain

et al.

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Injection of Amniotic Membrane and Umbilical Cord Particulate for Muscle and Ligament Tears in Collegiate Football Athletes: A Single-Center, Retrospective Study

Krystofiak

2024

ORR

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Background Football is a leading cause of sports-related injuries, accounting for more than half of time-loss injuries in men’s collegiate sports. Amniotic membrane and umbilical cord (AM/UC) powder injection is a novel treatment that may aid in functional recovery and return to play in collegiate athletes due to its anti-inflammatory, anti-scarring, and pro-regenerative properties. Methods A single-center, retrospective chart review was performed on consecutive college football players who sustained acute muscle or ligament tear and were subsequently treated with 50 or 100 mg injection of AM/UC powder (Clarix Flo, BioTissue, Miami, FL). Data collection included patient demographics, diagnosis, grade and extent of injury, position of the player, time to return to play (in days), and complications. Results Ten athletes with tears of the medial collateral ligament (n=3), hamstring (n=6), and abdomen (n=1) were included for analysis. The majority (n=6) of tears were partial (grade 2), with partial to full tears (grade 2±3) noted in 2 patients, and a complete tear (grade 3) noted in 2 patients. Athletes returned to play 29.6 ± 15.2 days post-injury, with 80% of athletes returning to play within 4 weeks. No complications or re-injuries occurred during the follow-up period of 6 months. Conclusion Injection of AM/UC powder is a safe treatment that enables quick return to play in this cohort of football players suffering from muscle or tendon tears. Prospective, randomized studies are warranted to verify whether injection of AM/UC can hasten return to play compared to the current standard treatment. Level of Evidence IV.

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Injection of Amniotic Membrane and Umbilical Cord Particulate for Muscle and Ligament Tears in Collegiate Football Athletes: A Single-Center, Retrospective Study

Krystofiak

2024

ORR

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Geographical variation in high-impact chronic pain and psychological associations at the regional level: a multilevel analysis of a large-scale internet-based cross-sectional survey

Wakaizumi,

Tanaka,

Shinohara

et al. 2024

Front. Public Health

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BackgroundA geographical analysis could be employed to uncover social risk factors and interventions linked to chronic pain. Nonetheless, geographical variation in chronic pain across different regions of Japan have not been well explored. This study aims to investigate geographical variation in high-impact chronic pain (HICP), defined as moderate to severe chronic pain, and examine the associated psychological factors at the prefecture level.MethodsA cross-sectional Internet-based survey involving 52,353 participants was conducted to assess chronic pain conditions, stress levels, mood states, educational levels, living status, regions, sleep duration, and exercise habits. A geographical analysis evaluated the prevalence of HICP at the prefecture level, and a multilevel analysis explored the risk factors for HICP at both individual and prefecture levels.ResultsThe geographical analysis revealed that Fukushima exhibited the highest HICP prevalence (23.2%; z-score = 2.11), Oita ranked second (23.0%; z-score = 2.00), and Okinawa showed the lowest prevalence (14.9%; z-score = −2.45). Geographical maps of Japan indicated that regional-level subjective stress, negative emotions, and short sleep were associated with higher HICP prevalence. In contrast, positive emotions, such as vigor, were associated with lower prevalence. Multilevel analysis revealed a significant improvement in model fit after incorporating psychological factors at the prefecture level (p < 0.001) and identified significant associations between high subjective stress and low vigor at the prefecture level with HICP prevalence (p < 0.001).ConclusionThere are regional differences in HICP prevalence, and at the prefecture level, subjective stress and vigor are associated with HICP.

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Evidence-Based Clinical Practice Guidelines on Regenerative Medicine Treatment for Chronic Pain: A Consensus Report from a Multispecialty Working Group

Cited by 2 publications

References 338 publications

Injection of Amniotic Membrane and Umbilical Cord Particulate for Muscle and Ligament Tears in Collegiate Football Athletes: A Single-Center, Retrospective Study

Injection of Amniotic Membrane and Umbilical Cord Particulate for Muscle and Ligament Tears in Collegiate Football Athletes: A Single-Center, Retrospective Study

Geographical variation in high-impact chronic pain and psychological associations at the regional level: a multilevel analysis of a large-scale internet-based cross-sectional survey

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