Evidence-based diagnostic use of VEMPs

Dlugaiczyk, Julia

doi:10.1007/s00106-019-00767-2

Cited by 15 publications

(17 citation statements)

References 84 publications

(167 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other NMSs disorders were also associated with VEMP responses, including sleep, perception, cognition, urinary problems, cardiovascular, and sexual dysfunction, although seemingly unrelated to vestibular function 6 , 9 , 10 . It was explained by the degeneration of several brainstem nuclei responsible for the motor and NMSs 9 , and by the VEMP circuit that spans the midbrain, the pons, and the medulla 14 , 15 . Considering our results that patient dizziness may result from vestibular dysfunction and the fact that VEMPs are useful to evaluate the vestibular system, we think that it may be clinically reasonable that VEMPs reflect dizziness rather than other NMSs in PD patients.…”

Section: Discussionmentioning

confidence: 99%

“…The oVEMP pathway presumably starts from the vestibular nucleus, crosses the midline, and ascends through the medial longitudinal fasciculus (MLF) at the upper pons and midbrain level, then to the ocular motor nuclei. The cVEMP presumably involves a descending pathway from the vestibular nucleus, ipsilateral medial vestibulospinal tract in the pons and medulla, then to the accessory motor neurons 14 , 15 . It has been suggested that upper brainstem function might be involved and lower brainstem function preserved in early PD patients 8 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dizziness in Parkinson’s disease patients is associated with vestibular function

Park

Kang

2021

Sci Rep

View full text Add to dashboard Cite

Dizziness is common in Parkinson’s disease (PD) patients. It is known that orthostatic hypotension (OH) is the main cause of such dizziness, but even without OH, quite a few PD patients complain of dizziness in the clinic. It can be regarded as non-specific because most of these patients have no neurological abnormalities. We hypothesized that this type of dizziness would be associated with vestibular function, although included patients did not have clinically confirmed vestibulopathy. We studied 84 patients without OH among 121 PD patients. Their clinical features and function were compared between patients with and without dizziness. Hoehn and Yahr stage (H&Y stage), the Unified Parkinson's Disease Rating Scale (UPDRS) part III, the Korean version of the Mini-Mental State Examination (K-MMSE), education years, disease duration, total levodopa equivalent daily dose (LEDD), the presence of dizziness, the dizziness severity, and orthostatic hypotension were tested. Vestibular evoked myogenic potentials (VEMPs) were used to characterize vestibular function. Ocular (oVEMPs) and cervical (cVEMPs) were recorded. oVEMPs in the right side showed significantly reduced potentials (p = 0.016) in PD patients with dizziness, but cVEMPs did not (all ps > 0.2). Bilateral absent oVEMP responses were more common in PD patients with dizziness (p = 0.022), but the frequencies of bilateral absent cVEMP responses were not different between the dizzy and non-dizzy groups (p = 0.898). Dizziness in PD patients without orthostatic hypotension may be associated with vestibular hypofunction. Our results provide evidence that can aid clinicians when making a treatment plan for patients with dizziness. i.e., strategies to enhance reduced vestibular function may be helpful, but this suggestion remains to be evaluated.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dizziness in Parkinson’s disease patients is associated with vestibular function

Park

Kang

2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Even if the acoustic sensitivity of the macula organs is only rudimentary in humans and evolution has provided for a largely independent functioning of the auditory and vestibular organs despite the anatomical connection 3 , it can still be used for diagnostic purposes: Stimulation of the otolith organs by sound, vibration, or galvanic stimuli may trigger a vestibular reflex that can be objectified by recording vestibular evoked myogenic potentials (VEMPs) 4 . In the case of suprathreshold stimulation with e. g. 500 Hz stimuli via air or bone conduction, potentials corresponding to the neuronal projections of saccule and utricle can be measured by means of electrodes at the contralateral eye muscles (oVEMPs, utricle) or the ipsilateral sternocleidomastoid muscle (cVEMPs, saccule) and the function of the macula organs can be assessed.…”

Section: Anatomy and Physiologymentioning

confidence: 99%

Interaktion von Hör- und Gleichgewichtssinn

Seiwerth

2023

Laryngorhinootologie

View full text Add to dashboard Cite

ZusammenfassungEs mehren sich zunehmend Hinweise, dass neben visuellen, vestibulären und somatosensorischen Afferenzen auch das Hören eine Rolle bei der Regulation des Gleichgewichts einnimmt. So scheint, insbesondere im Alter, ein progredienter Hörverlust auch mit einer Abnahme der Stabilität einherzugehen. Mehrere Studien untersuchten diesen Zusammenhang bei Normalhörenden, bei Patienten mit konventionellen Hörgeräten sowie nach Versorgung mit implantierbaren Hörsystemen wie auch bei Patienten mit vestibulären Störungen. Trotz der inhomogenen Datenlage und fehlenden Evidenz scheint das Hören mit dem Gleichgewichtsystem zu interagieren mit dem Potential, stabilisierend zu wirken. Es konnten darüber hinaus Erkenntnisse hinsichtlich audiovestibulärer Interaktionsmechanismen gewonnen werden, welche möglicherweise zukünftig in therapeutische Aspekte bei vestibulären Erkrankungen einfließen könnten. Es sind jedoch weitere prospektive kontrollierte Studien erforderlich, um diese Fragestellung auf evidenzbasiertes Niveau zu führen.

show abstract

“…To test the function of the saccule and the utricle, cervical vestibular evoked myogenic potentials (cVEMPs) and ocular vestibular myogenic potentials (oVEMPs) were used, respectively, as described before (28,29). cVEMP testing was conducted according to international guidelines using the Eclipse hardware (Interacoustics A/S, Middelfart, Denmark) while the test subject was sitting in a chair.…”

Section: Vestibular Testingmentioning

confidence: 99%

“…For every cVEMP and oVEMP recording, two runs were performed to demonstrate reproducibility, and responses were averaged. Asymmetry ratios (ARs) for oVEMP and cVEMP amplitudes were calculated as described previously, and an AR > 0.4 was considered to indicate a significant difference between the responses of both ears (28).…”

Section: Vestibular Testingmentioning

confidence: 99%

Prevalence of Endolymphatic Hydrops in Cochlear Implant Candidates with Idiopathic Profound Sensorineural Hearing Loss

et al. 2022

View full text Add to dashboard Cite

ObjectiveTo determine the prevalence of endolymphatic hydrops (EH) in cochlear implant (CI) candidates with idiopathic profound sensorineural hearing loss (SNHL) and its influence on the preservation of audiovestibular function after cochlear implantation.Study DesignProspective case series.SettingTertiary referral center.PatientsCI candidates with idiopathic progressive SNHL, but without classic EH-associated symptoms.InterventionsDelayed intravenous gadolinium-enhanced inner ear fluid-attenuated inversion recovery magnetic resonance imaging as well as pure-tone audiograms, video head impulse tests, and vestibular evoked myogenic potentials before and 4 weeks after cochlear implantation.Main Outcome MeasuresPrevalence of EH before cochlear implantation, audiovestibular function before and after surgery in hydropic and nonhydropic ears.ResultsThirty-two ears in 16 CI candidates were included. Nine ears (28%) with EH were detected. Although preoperative hearing thresholds, utricular function, and semicircular canal function were not different between the two groups, saccular function was reduced in hydropic ears. Ten subjects received a unilateral CI. Of these, 3 (30%) showed EH on the implanted side. There was no difference regarding postoperative hearing loss between the two groups, but the results point toward a higher vulnerability of hydropic ears with respect to loss of otolith function after cochlear implantation.ConclusionsThis is the first study showing that EH can be assumed in about one third of CI candidates with idiopathic profound SNHL, but no classic EH-associated symptoms. Preliminary results suggest that EH has no influence on the preservation of cochlear function but could be a risk factor for loss of otolith function after cochlear implantation.

show abstract

Evidence-based diagnostic use of VEMPs

Abstract: Evidence-based diagnostic use of VEMPs From neurophysiological principles to clinical application Electronic supplementary material The online version of this article (

Cited by 15 publications

References 84 publications

Dizziness in Parkinson’s disease patients is associated with vestibular function

Dizziness in Parkinson’s disease patients is associated with vestibular function

Interaktion von Hör- und Gleichgewichtssinn

Prevalence of Endolymphatic Hydrops in Cochlear Implant Candidates with Idiopathic Profound Sensorineural Hearing Loss

Contact Info

Product

Resources

About