Evidence based Evaluation of Antidiabetic Potential of Yesaka on Streptozotocin Diabetic Rats

Deore, Nitin D; Gupta, Shruti; Shrivastav, Birendra; Upasni, C. D.; Apte, Kishori; Shaikh, Abdulkader Mohamed

doi:10.5958/0974-360x.2018.00904.6

Cited by 4 publications

(3 citation statements)

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“…The findings of present study are similar with the findings of others that demonstrated the substantial antihyperglycemic properties of polyherbal formulation in STZ induced diabetic rats. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Our findings are similar with the findings of other authors. It has been demonstrated that our discoveries can decrease blood sugar levels in diabetic animals.…”

Section: Body Weight Of Ratssupporting

confidence: 91%

“…Throughout the study, the rodents were weighed on a regular basis, and the average difference in body mass was computed. 13,14 Determination of Lipid Profile It was on day 28 that the biochemical variables were measured; afterward, the rats were sacrificed through spinal displacement. The glucose oxidase technique was used to quantify total cholesterol (CHL), triglycerides (TGL), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL) employing an auto-analyzer.…”

Section: Anti-diabetic Activity Of the Polyherbal Formulationmentioning

confidence: 99%

“…The glucose oxidase technique was used to quantify total cholesterol (CHL), triglycerides (TGL), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL) employing an auto-analyzer. [12][13][14]…”

Section: Anti-diabetic Activity Of the Polyherbal Formulationmentioning

confidence: 99%

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Novel Antidiabetic Polyherbal Formulation for Synergistic Therapeutic Effects in Streptozotocin (STZ)-Induced Diabetic Rats

Bhaskarrao¹,

Singh²,

Vishal³

2022

IJDDT

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Worldwide demand for new anti-diabetic drugs from plant sources has increased as diabetes mellitus has become a global epidemic. In the era of herbal medicines, polyherbal formulations offer higher therapeutic efficacy than single plants due to synergistic effects. Therefore, the objective was to develop a novel anti-diabetic polyherbal formulation containing mixtures of three plants: Azadirachta indica leaves, Tinospora cordifolia stem and Ocimum sanctum leaves extracts. The eight different plant formulations (F1 to F8) were formulated while F1 to F3 contained a single plant extract. Hyperglycemia was developed in rodents by ingestion of streptozotocin. The experimental animals’ serum sugar level, body weight and lipid profile were determined. In the diabetic rats treated orally with F1 to F8, the blood glucose level decreased significantly compared to the diabetic control group. Similar effects were also observed in the diabetic rats treated with glibenclamide. In addition, F1 to F8 controlled lipid level, namely total cholesterol (CHL), triglycerides (TGL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels in rodents. The findings suggested that F7 showed higher anti-diabetic and antihyperlipidemic efficiency when equated to the other formulations. It was also found that the formulations (F1 to F3) containing a single plant extract exhibited lower therapeutic efficacy than the polyherbal formulations (F4 to F8). The results suggest that the higher therapeutic efficacy of the polyherbal formulation is due to the synergistic effect of the different phytoconstituents in the plant mixtures.

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Section: Body Weight Of Ratssupporting

confidence: 91%

Section: Anti-diabetic Activity Of the Polyherbal Formulationmentioning

confidence: 99%

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Novel Antidiabetic Polyherbal Formulation for Synergistic Therapeutic Effects in Streptozotocin (STZ)-Induced Diabetic Rats

Bhaskarrao¹,

Singh²,

Vishal³

2022

IJDDT

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Preparation and Evaluation of Novel Antidiabetic Polyherbal Formulation

Mahapatra¹,

Verma

2022

RJPT

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Polyherbal formulation having more than one plant in the particular dosage form. These formulation shows greater therapeutic efficacy compared to single plant. In the present study. It was intended to formulate antidiabetic polyherbal formulation incorporating different ratio of the Annona squamosa (leaves), Withania somnifera (roots), Tinospora cordifolia (stems)and Azadirachta indica (leaves). The seven different polyherbal formulation (HF1 to HF7) were prepared and administered orally to the streptozotocin induced diabetic rats. The experimental rats treated with the HF1 to HF7 and reference drug Glibenclamide significantly reduced the blood glucose level compared to the diabetic control group. Further, the HF1 to HF7 showed antihyperlipidemic activity by lowering the total cholesterol, triglycerides and low-density lipoprotein level as well asenhanced the high-density lipoprotein. The polyherbal formulations and reference drug improve the body wights of the rats. The HF6 demonstrated greater antidiabetic and antihyperlipidemic activity compared to other polyherbal formulations.

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Therapeutic investigations of palm oil induced beta-carotene in diabetic vascular dementia in rat

Giap

Varatharajan

Muthuraman

2023

RJPT

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Vascular dementia (VaD) is a major factor for the progress of stroke and other memory disorders. It is the second leading cause of death. The burden of VaD is higher in the aged population (>65 years). The progression of VaD occurs with lifestyle modifications i.e., fast food, smoking, and alcohol. The medicines for the treatment of VaD are limited. The palm oil is one of the rich sources of beta-carotene (BC). The present research designed to investigate the potential role of palm oil mill effluent derived BC in experimental model of diabetic VaD. The diabetic VaD was induced by administration of nicotinamide (NA, 50 mg/kg; i.p.) followed by streptozotocin (STZ, 50 mg/kg; i.p.). The test compound i.e., BC (50 and 100 mg/kg) and reference compound donepezil (1 mg/kg) were administered orally for 15 consecutive days. The changes of cognitive patterns i.e., escape latency time (ELT) and time spent in target quadrant (TSTQ) was assessed by Morris water maze (MWM) test. Besides the changes of neurotransmitter i.e., acetylcholinesterase (AChE) was estimated in brain (hippocampus, cerebellum, entorhinal cortex, amygdala and septum) samples. The administration of STZ caused the significant changes of cognitive functions (increased ELT and decreased TSTQ) as indicated in the development of VaD when compared to normal group. The treatment of BC was ameliorated the cognitive dysfunctions against the STZ associated cholinergic neurotransmitter (elevated AChE) changes. The effects were similar to donepezil treatment group. Hence, it proved that BC possesses the potential therapeutic effects in the management of diabetic VaD due to its potential anti-cholinergic effects.

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Evidence based Evaluation of Antidiabetic Potential of Yesaka on Streptozotocin Diabetic Rats

Cited by 4 publications

References 0 publications

Novel Antidiabetic Polyherbal Formulation for Synergistic Therapeutic Effects in Streptozotocin (STZ)-Induced Diabetic Rats

Novel Antidiabetic Polyherbal Formulation for Synergistic Therapeutic Effects in Streptozotocin (STZ)-Induced Diabetic Rats

Preparation and Evaluation of Novel Antidiabetic Polyherbal Formulation

Therapeutic investigations of palm oil induced beta-carotene in diabetic vascular dementia in rat

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