Evidence-based management of Mastalgia: A meta-analysis of randomised trials

Srivastava, Anurag; Mansel, Robert Edward; Arvind, Nand Kishore; Prasad, Kameshwar; Dhar, Anita; Chabra, Aroona

doi:10.1016/j.breast.2007.03.003

Cited by 89 publications

(55 citation statements)

References 19 publications

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“…After stopping the medication, the response rate was sustained only in 42% of cases at the end of 24 weeks. In a meta-analysis of 4 randomized trials we found a highly significant relief of mastalgia using Danazol, as compared to placebo [13]. The side effects of Danazol are mainly amenorrhea, the incidence of which increases with dose up to 100% at 600-800 mg per day.…”

Section: Discussionmentioning

confidence: 91%

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Centchroman Regresses Mastalgia: A Randomized Comparison with Danazol

et al. 2010

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We conducted a randomized trial to evaluate effectiveness of Centchroman in control of mastalgia and compared it with Danazol. Research Question-Is proportion of pain relief achieved by Centchroman similar to or inferior to that achieved by Danazol? In a randomized controlled trial of Centchroman vs. Danazol in mastalgia, 81 patients with mastalgia were studied. Thirty-nine patients were randomized to Danazol arm and 42 in Centchroman arm. The treatment was given for 12 weeks, followed by observation for 12 weeks. The pain was measured by visual analogue scale (VAS) of 0-10. At 12 weeks 89.7% women achieved reduction in pain score to ≤3 in Centchroman group (pvalue 0.001). In Danazol group 69.44% women achieved reduction in pain score to ≤ 3 (p=0.001). Three months after stopping therapy, Centchroman was more effective in pain score reduction at 24 weeks as compared to Danazol (p=0.019). Centchroman is an effective, safe and inexpensive alternative to Danazol for treatment of mastalgia.

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Section: Discussionmentioning

confidence: 91%

“…We have performed a meta-analysis of randomized trials on mastalgia and found Tamoxifen, Danazol, and Bromocriptine to be significantly effective in treatment of mastalgia when compared to placebo [13]. However the response to Evening Primrose oil was no better than placebo.…”

Section: Discussionmentioning

confidence: 99%

Centchroman Regresses Mastalgia: A Randomized Comparison with Danazol

et al. 2010

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“…Предложено множество методов лечения ма-сталгии, как немедикаментозных, так и с примене-нием лекарственных препаратов [14]. С учетом того, что этиология и патогенез масталгии, в том числе при ФКМ, неизвестны, не удивительно, что сведе-ния об эффективности большинства применяемых методов лечения противоречивы.…”

Section: рис 1 схема строения молочной железыunclassified

External application of gestagens for the treatment of mastalgia due to treatment with combined oral contraceptives in women with a fibrocystic breast changes

Андреева¹,

Grigoryan²,

Корженкова³

2016

Probl. reprod.

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“…In patients presenting with mastalgia and no mass on clinical examination, breast imaging is mainly required for excluding the existence of true underlying lesion and reassuring the patient. 13 Ultrasound is the modality of choice in young women to exclude significantmass or any other pathology. Cysts or hypertrophied periductal glandular tissues may be seen on ultrasound, however, there is significant overlap of this finding with normal women and hence, this finding is of no diagnostic use.…”

Section: Mastalgiamentioning

confidence: 99%

“…Others may respond to non steroidal anti inflammatory drugs. Refractory cases are treated with Danazol 13 Centchroman, a weak antiestrogen drug, is also effective.…”

Section: Mastalgiamentioning

confidence: 99%