Evidence based medical use of aloe vera extracts, short review of literature

Samarh, Samer Najeh Abdullah; Khalaf, Najm A.; Hajhamad, Mohammed M.

doi:10.18203/2320-6012.ijrms20174547

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…Acute Oral Toxicity Study: A detailed study on the acute oral toxicity of these plants was already reported by us revealed that the BS and AB extracts were non-toxic up to the dose of 2000 mg/kg 11,12 .…”

Section: In-vivo Anti-arthritic Activitymentioning

confidence: 95%

“…The preliminary acute toxicity of microsponge and individual plant extract showed no significant toxic effects upto 2000 mg/kg in rodents 11 . In light of the results of the literature studies on individual extracts, it was found to have good anti-inflammatory and anti-arthritic activities 12,13 . With this background, the present study was planned to screen anti-arthritic effect of a microsponge constituting powder extract of resins of B. serrata and leaves of A. barbadensis against Freund's complete adjuvant (FCA) induced arthritis in Male Wistar rats.…”

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2021

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The aim of the present study was to improve the release rate of herbal drugs by microsponges prepared through quasi-emulsion solvent diffusion technique using ethyl cellulose and PVA as carriers. The microsponges were characterized by FTIR, DSC and SEM studies followed by the determination of total drug content and entrapment efficiency. Anti-arthritic activity was evaluated by Freund's Complete Adjuvant (FCA) induced arthritic rat model. RA was induced by intradermal injection of 0.1 ml FCA in the left hind paw. The animals were treated with doses 50:50, 70:30, 30:70, and 100:100 mg/kg b.w. of microsponge formulation. Methotrexate at a dose of 10 mg/kg is used as a standard drug. Assessment of paw volume, % inhibition of paw volume, serum parameters for RA factor determination and histopathological examination was also carried out.In this current study, the microsponge formulation (B. serrata + A. barbadensis) had a better effect on controlling CFA induced arthritis. Formulation codes M1 and M4 showed a good reduction in paw edema and joint thickness. It produced a significant reduction of Rf values comparable to the methotrexate treated group. Therefore prepared microsponge has got definite effect in reducing the inflammatory components as well as the above-cited results also focus on its immunomodulatory role. Hence, the polymeric microsponge-based formulation of herbal drugs would be an anticipation and promising substitute to conventional therapy of rheumatoid arthritis and supports the common belief prevailing in traditional medicines worldwide. INTRODUCTION:Microsponges are at the forefront of the rapidly developing field of novel drug delivery technology. Microsponge, drug delivery technology, holds a great promise for reaching the goal of controlled and site-specific drug delivery and hence, has attracted wide attention of researchers in managing arthritic conditions.

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Section: In-vivo Anti-arthritic Activitymentioning

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“…Inside the skin there are bundles of vessels that are responsible for the transportation of substances such as water (xylem) and starch (phloem). All of them contain 75 potentially active constituents: vitamins, enzymes, minerals, sugar, lignin, saponins, salicylic acid, and amino acids which are very effective as an anti-inflammatory, antiseptic, anti-viral, antioxidant, and wound treatment 45. Effect of Aloe Vera on the Transforming Growth Factor (TGF-β) Expression in White Rat Cornea Wistar Strain Model for Chemical Base Trauma.…”

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The Effect of Aloe Vera Extract to Extensive Lesion and Expression of Transforming Growth Factor (TGF-β) on Alkaline Chemical Trauma Cornea Model

Fahcreza

Iskandar²,

Hidayat³

et al. 2018

sjo

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Abstract Background: Chemical trauma to the cornea is an emergency condition of the eye that requires early diagnosis and good treatment. Alkaline have ability to saponify fatty acids in cells and cell membranes which can make penetration into the stroma and destroy proteoglycans and collagen in cells. Aloe vera (AV) contains several active substances that are reported to have anti-inflammatory, immunomodulatory, and wound healing effects. AV has been reported to accelerate the healing process of corneal epithelial defects by increasing fibroblast proliferation, collagen production and growth factor production. This study aims to determine the difference between the effect of aloe vera extract with a concentration of 10%, 20%, 40% and BSS on the healing of extensive corneal lesions in white wistar rats alkaline trauma models. Method: This study was an experimental study with a pre and posttest only with control group design in vivo approach to 30 Wistar white rats which were divided into 5 treatment groups for 3 days. Comparative analysis of effectiveness using the ANNOVA test or the Kruskal Wallis test and continued by the post hoc test. Results: Based on the one way ANOVA test there was a statistically significant difference in effectiveness between the five treatment groups on the percentage of corneal wound healing area and TGF-β expression with an assessment of p = 0,000 each. The administration of alloevera (AV) concentration of 20% had a significant difference in percentage of healing of corneal lesions and TGF-β expression compared with other treatment groups with p = 0,000 each. Large differences in the area of corneal lesions in the 40% AV group were -0.45 in the BBS group, 0.146 in the 10% AV group, 0.493 in the 20% AV group. The difference in the AV group 10% was 0.30 in the BBS group, -064 in the AV group 20%, and -0.14 in the AV group 40%. However, TGFβ expression in the normal control group that did not receive treatment was 54.94 (53.21-56-12). TGFβ levels in the BSS group were 10.44, the 10% aloe vera group was 25.43, 47.99 for the 20% aloe vera group and 37.95 for the 40% aloe vera group. Conclusion: There is a difference between the effect of aloe vera extract with concentrations of 10%, 20%, 40% and BSS on the extensive healing of corneal lesions in white wistar rats with alkaline chemical trauma models.

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Evaluation of efficacy of Aloe vera (L.) Burm. f. gel solution in methylcellulose-induced ocular hypertension in New Zealand white rabbits

Vaghela

Barvaliya

Parmar³

et al. 2020

Journal of Basic and Clinical Physiology and Pharmacology

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ObjectivesThe present study aimed to evaluate the efficacy of Aloe vera in the methylcellulose-induced ocular hypertension model.MethodsFifty-six rabbits were randomly divided into seven groups. Intraocular pressure (IOP) was raised by anterior chamber injection of 2% methylcellulose in all the groups except the normal control group. Disease control animals were treated with sterile water and active control with topical 0.5% timolol 12 hourly; 6 and 12% A. vera gel topical solutions 8 hourly were given in group IV and V, respectively; 6 and 12% A. vera gel solutions along with timolol were given in group VI and VII animals, respectively. Mean IOP values and percentage of reduction in IOP were compared at 15 min, 30 min, 1 h, 2 h, 4 h, 8 h, 12 h, 24 h, 36 h, and 48 h.ResultsA. vera gel solutions (6 and 12%) showed a significant reduction in mean IOP from 4 to 2 h time points, respectively, whereas, A. vera gel solutions (6 and 12%) + timolol showed significant less mean IOP from a 30 min time point as compared with disease control. A. vera gel solutions (6 and 12%) showed 8.6 and 10.4% more reduction in IOP, respectively (66.8 ± 4.9% and 68.6 ± 5.4% vs. 58.2 ± 2.3%; p > 0.05), whereas 6 and 12% A. vera gel solutions along with timolol showed 14.5 and 16.2% more reduction in IOP, respectively (72.7 ± 4.7% and 74.4 ± 4.1% vs. 58.2 ± 2.3%; p < 0.05), than disease control group at 48 h.ConclusionsSix and twelve percent A. vera gel solutions reduced the IOP effectively. Concurrent treatment with 12% A. vera gel and timolol produced the maximum reduction in IOP.

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Evidence based medical use of aloe vera extracts, short review of literature

Cited by 4 publications

References 5 publications

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The Effect of Aloe Vera Extract to Extensive Lesion and Expression of Transforming Growth Factor (TGF-β) on Alkaline Chemical Trauma Cornea Model

Evaluation of efficacy of Aloe vera (L.) Burm. f. gel solution in methylcellulose-induced ocular hypertension in New Zealand white rabbits

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