Evidence-Based Medicine

Eaton, Charles

doi:10.1097/prs.0000000000000089

Cited by 48 publications

(14 citation statements)

References 54 publications

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“…11 Little is known about the quality of tissue after collagenase treatment. To date, few studies demonstrate higher recurrence rates compared with open surgery 28 (van Rijssen).…”

Section: Discussionmentioning

confidence: 99%

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Multiple Recurrences in Aggressive Forms of Dupuytren’s Disease—Can Patients Benefit from Repeated Selective Fasciectomy?

Könneker

Broelsch

Krezdorn

et al. 2017

Plastic and Reconstructive Surgery - Global Open

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Background:In Dupuytren’s disease (DD), limited fasciectomy is the mainstay of surgical therapy in patients at risk of contractures and disease recurrences. New minimally invasive treatments such as injection of collagenase clostridium histolyticum have evolved as a common tool for the preliminary treatment of Dupuytren’s contractures. However, recurrences and their therapy remain controversial. In this study, we evaluate the benefit of repeated limited fasciectomy in patients with aggressive forms of the disease and multiple recurrences of contractures.Methods:We evaluated the outcome of 16 patients undergoing limited fasciectomy 3 or more times on a single hand.Results:Postoperatively, 10 of 13 (76.9%) patients were satisfied with the clinical result after the last operation; 10 of 12 (83.3%) patients would choose to have their surgery repeated, if so needed. The mean improvement of proximal interphalangeal joint range of motion was 59.2 degrees (SD 26.8) and 86.2% (SD 19.9). There were no severe complications after treatment within the observed time period.Conclusions:Our findings demonstrate that patients with recurrence of contractures after multiple previous treatments in aggressive forms of DD can benefit from surgical intervention. In conclusion, repeated limited fasciectomy remains indicated in patients after previous surgeries with DD.

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“…11 Little is known about the quality of tissue after collagenase treatment. To date, few studies demonstrate higher recurrence rates compared with open surgery 28 (van Rijssen).…”

Section: Discussionmentioning

confidence: 99%

“…According to the literature, surgery is the most widely accepted option to treat contractures in DD. 8–11 Without treatment, DD can lead to severe flexion contraction at the MCP or PIP joints and cause functional loss of the hand. DD is still a predominant reason for elective finger amputation.…”

Section: Introductionmentioning

confidence: 99%

Multiple Recurrences in Aggressive Forms of Dupuytren’s Disease—Can Patients Benefit from Repeated Selective Fasciectomy?

Könneker

Broelsch

Krezdorn

et al. 2017

Plastic and Reconstructive Surgery - Global Open

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“…Disease progression leads to longitudinally oriented cord-like structures that limit extension of the involved fingers and ultimately to metacarpophalangeal (MCP) and interphalangeal joint (PIP or DIP) contractures [5]. Younger patients often have a more aggressive disease progression.…”

Section: Clinical Problems Of Dd and Current Therapeutic Possibilitiesmentioning

confidence: 99%

“…It is shown to be of particular value in MCP contractures [9]. However, recurrences are reported and complications of oedema, tendon rupture, pain and lymphadenopathy are described [5]. …”

Section: Minimally Invasive (Percutaneous) Treatmentmentioning

confidence: 99%

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Connective Tissue Degeneration: Mechanisms of Palmar Fascia Degeneration (Dupuytren’s Disease)

et al. 2016

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Dupuytren’s disease is a connective tissue disorder of the hand causing excessive palmar fascial fibrosis with associated finger contracture and disability. The aetiology of the disease is heterogeneous, with both genetic and environmental components. The connective tissue is abnormally infiltrated by myofibroblasts that deposit collagen and other extracellular matrix proteins. We describe the clinical profile of Dupuytren’s disease along with current therapeutic schemes. Recent findings on molecular and cellular parameters that are dysregulated in Dupuytren’s disease, which may contribute to the onset of the disease, and the role of resident inflammation promoting fibrosis, are highlighted. We review recent literature focusing on non-myofibroblast cell types (stem cell-like cells), their pro-inflammatory and pro-fibrotic role that may account for abnormal wound healing response.

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An Overview of Dupuytren’s Disease for Perioperative Nurses

Russell¹

2021

AORN Journal

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indicates that continuing education (CE) contact hours are available for this activity. Earn the CE contact hours by reading this article, reviewing the outcome and objectives, and completing the online Examination and Learner Evaluation at https://aorn.us/Jan22 -cea. A score of 70% correct on the examination is required for credit. Participants receive feedback on incorrect answers. Each applicant who successfully completes this program can immediately print a certificate of completion. SPONSORSHIP OR COMMERCIAL SUPPORTNo sponsorship or commercial support was received for this article. DISCLAIMERAORN recognizes these activities as CE for RNs. This recognition does not imply that AORN or the American Nurses Credentialing Center approves or endorses products mentioned in the activity.

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Evidence-Based Medicine

Cited by 48 publications

References 54 publications

Multiple Recurrences in Aggressive Forms of Dupuytren’s Disease—Can Patients Benefit from Repeated Selective Fasciectomy?

Multiple Recurrences in Aggressive Forms of Dupuytren’s Disease—Can Patients Benefit from Repeated Selective Fasciectomy?

Connective Tissue Degeneration: Mechanisms of Palmar Fascia Degeneration (Dupuytren’s Disease)

An Overview of Dupuytren’s Disease for Perioperative Nurses

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