“…Within the literature, several empirical studies have examined the utility of CRP testing in the triage 66 and diagnosis 67,68 of acute abdominal pain, as well as its role in the evaluation of patients presenting to the ED with chest pain. 69,70 In addition, numerous guidelines are available to assist ED clinicians with assessing both abdominal pain 41,42,[71][72][73] and chest pain 49,71,74 ; however, the choice of diagnostic test(s) can be affected by a range of factors, including patient history, symptoms, and physical examination, 41,49,73 and ultimately clinical judgment. 71 Thus, the interpretation of the findings from our study needs to be reviewed in the context of each ED setting and the characteristics of its patient presentations, as recommended by Buchan et al 12 and Bojakowski, 75 who have highlighted the need for local-level contextualized evaluation in determining why variations exist.…”