Evidence-based medicine—from best research evidence to a better surgical practice and health care

Antes, Gerd; Sauerland, Stefan; Seiler, Christoph M.

doi:10.1007/s00423-005-0006-4

Cited by 41 publications

(32 citation statements)

References 33 publications

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“…Evidence-based care is particularly challenging in surgery, for which there are few randomized trials to guide practice. 10,[24][25][26][27] We are not aware of any thorough studies examining the information needs of general surgeons, who, as do general practitioners, care for patients with a wide variety of conditions including cancer, a leading cause of premature death worldwide. One study reported that surgeons more frequently seek information from colleagues than family physicians do.…”

Section: Introductionmentioning

confidence: 99%

The role of collegial interaction in continuing professional development

Gagliardi

Wright

Anderson

et al. 2007

Journal of Continuing Education in the Health Professions

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Section: Introductionmentioning

confidence: 99%

The role of collegial interaction in continuing professional development

Gagliardi

Wright

Anderson

et al. 2007

Journal of Continuing Education in the Health Professions

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“…Systematic reviews form a key role in the process of research synthesis, and therefore, make research findings available for the general medical community [39]. …”

Section: Knowledge Transfer Into Clinical Practicementioning

confidence: 99%

Study Methods in Evidence-Based Surgery: Methodological Impediments and Suggested Approaches for the Creation and Transfer of Knowledge in Surgery

et al. 2014

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Background: Since its introduction more than 20 years ago, evidence-based medicine has become an important principle in the daily routine of clinicians around the globe. Nevertheless, many surgical interventions are still not based on high-quality evidence from clinical trials. This is partially due to the fact that surgical trials pose some specific obstacles, which have to be overcome during the planning and conduct of such a trial. Objective: In this study, we will highlight specific challenges and discuss explicit obstacles of surgical clinical research. Moreover, potential solutions will be substantiated by the experience of the Study Centre of the German Surgical Society (SDGC) in surgical clinical research. Conclusions: Surgical researchers should be equipped with a basic knowledge of research methodology to be able to overcome the common impediments posed by surgical trials. Collaborations between surgeons and methodologists as well as trial networks have proven to be useful in accomplishing high-quality surgical research in various randomized controlled trials. By maintaining and refining this work and with sufficient and prompt translation of investigational knowledge into daily practice, the treatment of surgical patients should result in an improved outcome in the future.

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“…Nützlich ist in diesem Fall die genaue Kenntnis und Akzeptanz der Operationstechniken in den an der Studie teilnehmenden Prüfzentren [15]. Um eine möglichst hohe Übertragbarkeit (external validity) der Studienergebnisse zu erreichen, sollten insbesondere Studien zu Interventionen durchgeführt werden, die für die tägliche chirurgische Versorgung von Bedeutung sind [2]. Im Studienprotokoll ist es dann ausreichend, die Grenzen für einen solchen Versorgungskorridor festzulegen.…”

Section: Introductionunclassified

Klinische Studien außerhalb des Arzneimittelgesetzes

Seiler

Rossion

Diener

2009

Bundesgesundheitsbl.

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Proof of safety and effectiveness of surgical procedures follows the same scientific principles as for drugs. Control of bias and chance when evaluating new operations has to be considered and should generally be followed using randomized controlled trials (RCT). The expenditure for study design, execution and analysis can be substantial due to specific characteristics of surgical treatments. The largest challenges represent the maintenance of comparable treatment and assessment within and between the study groups of a RCT, such as, blinding of surgeons, learning curves, standardization of procedures, and monitoring interventions to ensure execution according to protocol. This evaluation is made even more difficult due to lack of broadly accepted definitions of surgically relevant endpoints in daily practice and research. Since 2004, new methods and procedures are being tested to demonstrate the feasibility of surgical RCTs through a grant program for surgical clinical trial centers in Germany. In six surgical trial centers, a number of surgical RCTs have been designed and conducted. The first results of high-quality surgical RCTs are described.

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Evidence-based medicine—from best research evidence to a better surgical practice and health care

Abstract: As currently only 77 Cochrane reviews address surgical procedures; much work remains to be done to enlarge the number of high-quality and relevant reviews. Similarly, the number and quality of randomized controlled trials need to be increased in all surgical specialties.

Cited by 41 publications

References 33 publications

The role of collegial interaction in continuing professional development

The role of collegial interaction in continuing professional development

Study Methods in Evidence-Based Surgery: Methodological Impediments and Suggested Approaches for the Creation and Transfer of Knowledge in Surgery

Klinische Studien außerhalb des Arzneimittelgesetzes

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