Evidence-based pediatric pulmonary medicine: how can it help?

Response to evidence-based medicine

“…Sir, Dr. Marino suggests that there is some conflict between the views expressed by Bush in an editorial concerning dornase alfa in cystic fibrosis 1 and in my article on evidence-based medicine in the same issue of Pediatric Pulmonology. 2 The basis for this appears to be that Bush while stating that ''-dornase alfa has earned an established place in the treatment of CF on the basis of an impressive body of evidence'' also identified and discussed the limitations of using FEV 1 as an outcome measure in clinical trials in cystic fibrosis.…”